Incretin hormone secretion over the day.
(2010) In Vitamines and Hormones 84. p.203-220- Abstract
- The two incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are key factors in the regulation of islet function and glucose metabolism, and incretin-based therapy for type 2 diabetes has gained considerable interest during recent years. Regulation of incretin hormone secretion is less well characterized. The main stimulus for incretin hormone secretion is presence of nutrients in the intestinal lumen, and carbohydrate, fat as well as protein all have the capacity to stimulate GIP and GLP-1 secretion. More recently, it has been established that a diurnal regulation exists with incretin hormone secretion to an identical meal being greater when the meal is served in the morning compared to... (More)
- The two incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are key factors in the regulation of islet function and glucose metabolism, and incretin-based therapy for type 2 diabetes has gained considerable interest during recent years. Regulation of incretin hormone secretion is less well characterized. The main stimulus for incretin hormone secretion is presence of nutrients in the intestinal lumen, and carbohydrate, fat as well as protein all have the capacity to stimulate GIP and GLP-1 secretion. More recently, it has been established that a diurnal regulation exists with incretin hormone secretion to an identical meal being greater when the meal is served in the morning compared to in the afternoon. Finally, whether incretin hormone secretion is altered in disease states is an area with, so far, controversial results in different studies, although some studies have demonstrated reduced incretin hormone secretion in type 2 diabetes. This review summarizes our knowledge on regulation of incretin hormone secretion and its potential changes in disease states. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1731711
- author
- Ahrén, Bo LU ; Carr, Richard D and Deacon, Carolyn F
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Vitamines and Hormones
- volume
- 84
- pages
- 203 - 220
- publisher
- Academic Press
- external identifiers
-
- wos:000285483500007
- pmid:21094901
- scopus:78649341328
- pmid:21094901
- ISSN
- 0083-6729
- DOI
- 10.1016/B978-0-12-381517-0.00007-2
- language
- English
- LU publication?
- yes
- id
- 48bcbd57-bec4-40c0-93db-4d80ac9524cc (old id 1731711)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21094901?dopt=Abstract
- date added to LUP
- 2016-04-04 08:56:03
- date last changed
- 2024-01-12 07:52:16
@article{48bcbd57-bec4-40c0-93db-4d80ac9524cc,
abstract = {{The two incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are key factors in the regulation of islet function and glucose metabolism, and incretin-based therapy for type 2 diabetes has gained considerable interest during recent years. Regulation of incretin hormone secretion is less well characterized. The main stimulus for incretin hormone secretion is presence of nutrients in the intestinal lumen, and carbohydrate, fat as well as protein all have the capacity to stimulate GIP and GLP-1 secretion. More recently, it has been established that a diurnal regulation exists with incretin hormone secretion to an identical meal being greater when the meal is served in the morning compared to in the afternoon. Finally, whether incretin hormone secretion is altered in disease states is an area with, so far, controversial results in different studies, although some studies have demonstrated reduced incretin hormone secretion in type 2 diabetes. This review summarizes our knowledge on regulation of incretin hormone secretion and its potential changes in disease states.}},
author = {{Ahrén, Bo and Carr, Richard D and Deacon, Carolyn F}},
issn = {{0083-6729}},
language = {{eng}},
pages = {{203--220}},
publisher = {{Academic Press}},
series = {{Vitamines and Hormones}},
title = {{Incretin hormone secretion over the day.}},
url = {{http://dx.doi.org/10.1016/B978-0-12-381517-0.00007-2}},
doi = {{10.1016/B978-0-12-381517-0.00007-2}},
volume = {{84}},
year = {{2010}},
}