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Incretin hormone secretion over the day.

Ahrén, Bo LU ; Carr, Richard D and Deacon, Carolyn F (2010) In Vitamines and Hormones 84. p.203-220
Abstract
The two incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are key factors in the regulation of islet function and glucose metabolism, and incretin-based therapy for type 2 diabetes has gained considerable interest during recent years. Regulation of incretin hormone secretion is less well characterized. The main stimulus for incretin hormone secretion is presence of nutrients in the intestinal lumen, and carbohydrate, fat as well as protein all have the capacity to stimulate GIP and GLP-1 secretion. More recently, it has been established that a diurnal regulation exists with incretin hormone secretion to an identical meal being greater when the meal is served in the morning compared to... (More)
The two incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are key factors in the regulation of islet function and glucose metabolism, and incretin-based therapy for type 2 diabetes has gained considerable interest during recent years. Regulation of incretin hormone secretion is less well characterized. The main stimulus for incretin hormone secretion is presence of nutrients in the intestinal lumen, and carbohydrate, fat as well as protein all have the capacity to stimulate GIP and GLP-1 secretion. More recently, it has been established that a diurnal regulation exists with incretin hormone secretion to an identical meal being greater when the meal is served in the morning compared to in the afternoon. Finally, whether incretin hormone secretion is altered in disease states is an area with, so far, controversial results in different studies, although some studies have demonstrated reduced incretin hormone secretion in type 2 diabetes. This review summarizes our knowledge on regulation of incretin hormone secretion and its potential changes in disease states. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Vitamines and Hormones
volume
84
pages
203 - 220
publisher
Academic Press
external identifiers
  • wos:000285483500007
  • pmid:21094901
  • scopus:78649341328
ISSN
0083-6729
DOI
10.1016/B978-0-12-381517-0.00007-2
language
English
LU publication?
yes
id
48bcbd57-bec4-40c0-93db-4d80ac9524cc (old id 1731711)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21094901?dopt=Abstract
date added to LUP
2010-12-01 13:24:40
date last changed
2018-05-29 10:10:33
@article{48bcbd57-bec4-40c0-93db-4d80ac9524cc,
  abstract     = {The two incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are key factors in the regulation of islet function and glucose metabolism, and incretin-based therapy for type 2 diabetes has gained considerable interest during recent years. Regulation of incretin hormone secretion is less well characterized. The main stimulus for incretin hormone secretion is presence of nutrients in the intestinal lumen, and carbohydrate, fat as well as protein all have the capacity to stimulate GIP and GLP-1 secretion. More recently, it has been established that a diurnal regulation exists with incretin hormone secretion to an identical meal being greater when the meal is served in the morning compared to in the afternoon. Finally, whether incretin hormone secretion is altered in disease states is an area with, so far, controversial results in different studies, although some studies have demonstrated reduced incretin hormone secretion in type 2 diabetes. This review summarizes our knowledge on regulation of incretin hormone secretion and its potential changes in disease states.},
  author       = {Ahrén, Bo and Carr, Richard D and Deacon, Carolyn F},
  issn         = {0083-6729},
  language     = {eng},
  pages        = {203--220},
  publisher    = {Academic Press},
  series       = {Vitamines and Hormones},
  title        = {Incretin hormone secretion over the day.},
  url          = {http://dx.doi.org/10.1016/B978-0-12-381517-0.00007-2},
  volume       = {84},
  year         = {2010},
}