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Malignancies among women who gave birth after in vitro fertilization.

Källén, Bengt LU ; Finnström, O; Lindam, A; Nilsson, E; Nygren, K-G and Otterblad Olausson, P (2011) In Human Reproduction Dec. p.253-258
Abstract
BACKGROUND Relatively few studies published to date have investigated IVF and cancer risk. In this study we compared the occurrence of cancer in women who gave birth after IVF with all other women who gave birth in the study period. METHODS All women who were treated with IVF and gave birth during the years 1982-2006 in Sweden were identified from all IVF clinics, and the occurrence of cancer in these women was identified by linkage with the nationwide Swedish cancer register. Comparison was made with Mantel-Haenszel odds ratios (ORs), adjusting for year of delivery and maternal age, parity and smoking. Cancer before IVF was only studied in first parity women. Specific cancer forms were also studied. RESULTS Among 24058 women who had been... (More)
BACKGROUND Relatively few studies published to date have investigated IVF and cancer risk. In this study we compared the occurrence of cancer in women who gave birth after IVF with all other women who gave birth in the study period. METHODS All women who were treated with IVF and gave birth during the years 1982-2006 in Sweden were identified from all IVF clinics, and the occurrence of cancer in these women was identified by linkage with the nationwide Swedish cancer register. Comparison was made with Mantel-Haenszel odds ratios (ORs), adjusting for year of delivery and maternal age, parity and smoking. Cancer before IVF was only studied in first parity women. Specific cancer forms were also studied. RESULTS Among 24058 women who had been treated with IVF, 1279 appeared in the cancer register. The total number of women studied in the population was 1 394 061, and 95 775 of these were registered in the cancer register. The risk for cancer before IVF was increased [OR 1.37, 95% confidence interval (CI) 1.27-1.48] and was especially high for ovarian cancer (3.93). The risk for cancer after IVF was significantly lower (OR 0.74, 95% CI 0.67-0.82), mainly due to a lower than expected risk for breast and cervical cancer. The risk for ovarian cancer was increased but lower than the risk before IVF (2.13). CONCLUSIONS Cancer or cancer treatment may increase the risk for infertility leading to IVF. After IVF, in most cases with treatment with fertility hormones, a significantly low cancer risk was found. Ovarian cancer showed an increased risk, although lower than before IVF. One possible reason is ovarian pathology causing both infertility and an increased cancer risk. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Human Reproduction
volume
Dec
pages
253 - 258
publisher
Oxford University Press
external identifiers
  • wos:000285627200030
  • pmid:21088017
  • scopus:78650717240
ISSN
0268-1161
DOI
10.1093/humrep/deq307
language
English
LU publication?
yes
id
45a128a9-5910-4e4a-b5fe-c8af149f88ed (old id 1731816)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21088017?dopt=Abstract
date added to LUP
2010-12-01 12:46:30
date last changed
2017-08-06 04:45:05
@article{45a128a9-5910-4e4a-b5fe-c8af149f88ed,
  abstract     = {BACKGROUND Relatively few studies published to date have investigated IVF and cancer risk. In this study we compared the occurrence of cancer in women who gave birth after IVF with all other women who gave birth in the study period. METHODS All women who were treated with IVF and gave birth during the years 1982-2006 in Sweden were identified from all IVF clinics, and the occurrence of cancer in these women was identified by linkage with the nationwide Swedish cancer register. Comparison was made with Mantel-Haenszel odds ratios (ORs), adjusting for year of delivery and maternal age, parity and smoking. Cancer before IVF was only studied in first parity women. Specific cancer forms were also studied. RESULTS Among 24058 women who had been treated with IVF, 1279 appeared in the cancer register. The total number of women studied in the population was 1 394 061, and 95 775 of these were registered in the cancer register. The risk for cancer before IVF was increased [OR 1.37, 95% confidence interval (CI) 1.27-1.48] and was especially high for ovarian cancer (3.93). The risk for cancer after IVF was significantly lower (OR 0.74, 95% CI 0.67-0.82), mainly due to a lower than expected risk for breast and cervical cancer. The risk for ovarian cancer was increased but lower than the risk before IVF (2.13). CONCLUSIONS Cancer or cancer treatment may increase the risk for infertility leading to IVF. After IVF, in most cases with treatment with fertility hormones, a significantly low cancer risk was found. Ovarian cancer showed an increased risk, although lower than before IVF. One possible reason is ovarian pathology causing both infertility and an increased cancer risk.},
  author       = {Källén, Bengt and Finnström, O and Lindam, A and Nilsson, E and Nygren, K-G and Otterblad Olausson, P},
  issn         = {0268-1161},
  language     = {eng},
  pages        = {253--258},
  publisher    = {Oxford University Press},
  series       = {Human Reproduction},
  title        = {Malignancies among women who gave birth after in vitro fertilization.},
  url          = {http://dx.doi.org/10.1093/humrep/deq307},
  volume       = {Dec},
  year         = {2011},
}