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Electrostatic Chameleons in Biological Systems.

Lund, Mikael LU (2010) In Journal of the American Chemical Society 132(49). p.17337-17339
Abstract
Due to large equilibrium fluctuations of protons at physiological pH, the orthophosphate ion as well as the imidazole group on histidine substantially regulate their charge upon approaching charged interfaces. This implies that these-and comparable-ions function as electostatic "proximity switches" when interacting with lipid membranes, DNA, proteins, etc. Using straightforward statistical thermodynamics as well as mesoscopic computer simulations we quantify the charge regulation mechanism and argue that it is important in a range of biological as well as technical processes.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of the American Chemical Society
volume
132
issue
49
pages
17337 - 17339
publisher
The American Chemical Society (ACS)
external identifiers
  • wos:000285328800001
  • pmid:21086991
  • scopus:78650135532
  • pmid:21086991
ISSN
1520-5126
DOI
10.1021/ja106480a
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Theoretical Chemistry (S) (011001039)
id
a8897a0e-2ce5-4c01-8f75-f2ceeaa3de33 (old id 1731830)
date added to LUP
2016-04-01 14:52:56
date last changed
2020-01-12 17:31:38
@article{a8897a0e-2ce5-4c01-8f75-f2ceeaa3de33,
  abstract     = {Due to large equilibrium fluctuations of protons at physiological pH, the orthophosphate ion as well as the imidazole group on histidine substantially regulate their charge upon approaching charged interfaces. This implies that these-and comparable-ions function as electostatic "proximity switches" when interacting with lipid membranes, DNA, proteins, etc. Using straightforward statistical thermodynamics as well as mesoscopic computer simulations we quantify the charge regulation mechanism and argue that it is important in a range of biological as well as technical processes.},
  author       = {Lund, Mikael},
  issn         = {1520-5126},
  language     = {eng},
  number       = {49},
  pages        = {17337--17339},
  publisher    = {The American Chemical Society (ACS)},
  series       = {Journal of the American Chemical Society},
  title        = {Electrostatic Chameleons in Biological Systems.},
  url          = {http://dx.doi.org/10.1021/ja106480a},
  doi          = {10.1021/ja106480a},
  volume       = {132},
  year         = {2010},
}