Risk of second cancers after the diagnosis of Merkel cell carcinoma in Scandinavia.
(2011) In British Journal of Cancer 104. p.178-180- Abstract
- Background:Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumour of the skin that has been associated with a new tumour virus, the MCC polyomavirus.Methods:To investigate whether MCC may have a shared aetiology with other cancers, we investigated the risk of second cancers after the diagnosis of MCC using the national cancer registries in Denmark, Norway and Sweden.Results:The overall cancer incidence was increased among patients diagnosed with MCC compared with the general population in these countries (79 secondary cancers total, Standardized Incidence Ratio (SIR) 1.38 (95% confidence interval (CI): 1.10-1.72); 49 secondary cancer in females, SIR 1.7 (95% CI: 1.29-2.25); 30 secondary cancers in males and SIR 1.05 (95% CI:... (More)
- Background:Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumour of the skin that has been associated with a new tumour virus, the MCC polyomavirus.Methods:To investigate whether MCC may have a shared aetiology with other cancers, we investigated the risk of second cancers after the diagnosis of MCC using the national cancer registries in Denmark, Norway and Sweden.Results:The overall cancer incidence was increased among patients diagnosed with MCC compared with the general population in these countries (79 secondary cancers total, Standardized Incidence Ratio (SIR) 1.38 (95% confidence interval (CI): 1.10-1.72); 49 secondary cancer in females, SIR 1.7 (95% CI: 1.29-2.25); 30 secondary cancers in males and SIR 1.05 (95% CI: 0.73-1.5)). There were significantly increased incidence ratios for non-melanoma skin cancers (34 secondary cancers, SIR 8.35 (95% CI: 5.97-11.68)), melanoma of skin (6 secondary cancers, SIR 4.29 (95% CI: 1.93-9.56)) and laryngeal cancer (2 secondary cancers, SIR 9.51 (95% CI: 2.38-38)). The SIRs for these three cancer sites were also elevated on restricting the follow-up to cancers occurring at least one year after MCC diagnosis.Conclusions:Patients diagnosed with MCC are at increased risk of a second cancer, particularly, other skin cancers. Conceivable explanations include the impact of increased surveillance of the skin and shared causative factors, for example, ultraviolet light exposure or MCC polyomavirus infection.British Journal of Cancer advance online publication, 16 November 2010; doi:10.1038/sj.bjc.6605989 www.bjcancer.com. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1731881
- author
- Bzhalava, Davit LU ; Bray, F ; Storm, H and Dillner, Joakim LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- British Journal of Cancer
- volume
- 104
- pages
- 178 - 180
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000285915900025
- pmid:21081931
- scopus:78650857645
- pmid:21081931
- ISSN
- 1532-1827
- DOI
- 10.1038/sj.bjc.6605989
- language
- English
- LU publication?
- yes
- id
- 17dd18cf-3ba0-47c7-af4a-00bd0aee4579 (old id 1731881)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21081931?dopt=Abstract
- date added to LUP
- 2016-04-01 10:21:08
- date last changed
- 2022-02-10 01:15:36
@article{17dd18cf-3ba0-47c7-af4a-00bd0aee4579,
abstract = {{Background:Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumour of the skin that has been associated with a new tumour virus, the MCC polyomavirus.Methods:To investigate whether MCC may have a shared aetiology with other cancers, we investigated the risk of second cancers after the diagnosis of MCC using the national cancer registries in Denmark, Norway and Sweden.Results:The overall cancer incidence was increased among patients diagnosed with MCC compared with the general population in these countries (79 secondary cancers total, Standardized Incidence Ratio (SIR) 1.38 (95% confidence interval (CI): 1.10-1.72); 49 secondary cancer in females, SIR 1.7 (95% CI: 1.29-2.25); 30 secondary cancers in males and SIR 1.05 (95% CI: 0.73-1.5)). There were significantly increased incidence ratios for non-melanoma skin cancers (34 secondary cancers, SIR 8.35 (95% CI: 5.97-11.68)), melanoma of skin (6 secondary cancers, SIR 4.29 (95% CI: 1.93-9.56)) and laryngeal cancer (2 secondary cancers, SIR 9.51 (95% CI: 2.38-38)). The SIRs for these three cancer sites were also elevated on restricting the follow-up to cancers occurring at least one year after MCC diagnosis.Conclusions:Patients diagnosed with MCC are at increased risk of a second cancer, particularly, other skin cancers. Conceivable explanations include the impact of increased surveillance of the skin and shared causative factors, for example, ultraviolet light exposure or MCC polyomavirus infection.British Journal of Cancer advance online publication, 16 November 2010; doi:10.1038/sj.bjc.6605989 www.bjcancer.com.}},
author = {{Bzhalava, Davit and Bray, F and Storm, H and Dillner, Joakim}},
issn = {{1532-1827}},
language = {{eng}},
pages = {{178--180}},
publisher = {{Nature Publishing Group}},
series = {{British Journal of Cancer}},
title = {{Risk of second cancers after the diagnosis of Merkel cell carcinoma in Scandinavia.}},
url = {{https://lup.lub.lu.se/search/files/1768738/1748178.pdf}},
doi = {{10.1038/sj.bjc.6605989}},
volume = {{104}},
year = {{2011}},
}