Increased Cartilage Oligomeric Matrix Protein Concentrations in Equine Digital Flexor Tendon Sheath Synovial Fluid Predicts Intrathecal Tendon Damage.
(2011) In Veterinary surgery : VS : the official journal of the American College of Veterinary Surgeons Dec. p.54-58- Abstract
- Objectives: To evaluate digital flexor tendon sheath (DFTS) synovial fluid cartilage oligomeric matrix protein (COMP) concentrations as a molecular marker for intrathecal pathology. Study Design: Case control study. Animals: Horses (n=46) with DFTS tenosynovitis; 23 fresh cadaver horses. Methods: DFTS synovial fluid samples were collected from clinical cases with noninfected DFTS tenosynovitis and from control DFTS. Clinical and surgical findings were recorded, and dissection of control limbs was performed to confirm the DFTS to be grossly normal. Synovial fluid COMP was quantified using a homologous competitive inhibition ELISA. Results: Abnormalities were identified tenoscopically: intrathecal tendon/ligament tearing was identified in 37... (More)
- Objectives: To evaluate digital flexor tendon sheath (DFTS) synovial fluid cartilage oligomeric matrix protein (COMP) concentrations as a molecular marker for intrathecal pathology. Study Design: Case control study. Animals: Horses (n=46) with DFTS tenosynovitis; 23 fresh cadaver horses. Methods: DFTS synovial fluid samples were collected from clinical cases with noninfected DFTS tenosynovitis and from control DFTS. Clinical and surgical findings were recorded, and dissection of control limbs was performed to confirm the DFTS to be grossly normal. Synovial fluid COMP was quantified using a homologous competitive inhibition ELISA. Results: Abnormalities were identified tenoscopically: intrathecal tendon/ligament tearing was identified in 37 cases and 9 had other lesions. In control horses, synovial fluid COMP was higher in younger horses. Clinical cases with intrathecal tendon/ligament tearing had higher synovial fluid COMP than either clinical cases with other lesions, or controls. In horses ≥5 years old, the sensitivity and specificity of the assay was high for diagnosing intrathecal tendon/ligament tearing. Conclusions: COMP concentrations in DFTS synovial fluid were significantly greater than those in normal horses with noninfected tenosynovitis caused by intrathecal tendon/ligament tearing, but not by other lesions. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1731973
- author
- Smith, Matthew R W ; Wright, Ian M ; Minshall, Gaynor J ; Dudhia, Jay ; Verheyen, Kristien ; Heinegård, Dick LU and Smith, Roger LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Veterinary surgery : VS : the official journal of the American College of Veterinary Surgeons
- volume
- Dec
- pages
- 54 - 58
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000285833600009
- pmid:21077920
- scopus:78650746465
- ISSN
- 1532-950X
- DOI
- 10.1111/j.1532-950X.2010.00751.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division III (013230700), Connective Tissue Biology (013230151)
- id
- c2f69514-c905-4ac7-94b7-0977e0f1ce4c (old id 1731973)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21077920?dopt=Abstract
- date added to LUP
- 2016-04-04 09:43:21
- date last changed
- 2022-03-15 20:39:54
@article{c2f69514-c905-4ac7-94b7-0977e0f1ce4c, abstract = {{Objectives: To evaluate digital flexor tendon sheath (DFTS) synovial fluid cartilage oligomeric matrix protein (COMP) concentrations as a molecular marker for intrathecal pathology. Study Design: Case control study. Animals: Horses (n=46) with DFTS tenosynovitis; 23 fresh cadaver horses. Methods: DFTS synovial fluid samples were collected from clinical cases with noninfected DFTS tenosynovitis and from control DFTS. Clinical and surgical findings were recorded, and dissection of control limbs was performed to confirm the DFTS to be grossly normal. Synovial fluid COMP was quantified using a homologous competitive inhibition ELISA. Results: Abnormalities were identified tenoscopically: intrathecal tendon/ligament tearing was identified in 37 cases and 9 had other lesions. In control horses, synovial fluid COMP was higher in younger horses. Clinical cases with intrathecal tendon/ligament tearing had higher synovial fluid COMP than either clinical cases with other lesions, or controls. In horses ≥5 years old, the sensitivity and specificity of the assay was high for diagnosing intrathecal tendon/ligament tearing. Conclusions: COMP concentrations in DFTS synovial fluid were significantly greater than those in normal horses with noninfected tenosynovitis caused by intrathecal tendon/ligament tearing, but not by other lesions.}}, author = {{Smith, Matthew R W and Wright, Ian M and Minshall, Gaynor J and Dudhia, Jay and Verheyen, Kristien and Heinegård, Dick and Smith, Roger}}, issn = {{1532-950X}}, language = {{eng}}, pages = {{54--58}}, publisher = {{Wiley-Blackwell}}, series = {{Veterinary surgery : VS : the official journal of the American College of Veterinary Surgeons}}, title = {{Increased Cartilage Oligomeric Matrix Protein Concentrations in Equine Digital Flexor Tendon Sheath Synovial Fluid Predicts Intrathecal Tendon Damage.}}, url = {{http://dx.doi.org/10.1111/j.1532-950X.2010.00751.x}}, doi = {{10.1111/j.1532-950X.2010.00751.x}}, volume = {{Dec}}, year = {{2011}}, }