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Increased Cartilage Oligomeric Matrix Protein Concentrations in Equine Digital Flexor Tendon Sheath Synovial Fluid Predicts Intrathecal Tendon Damage.

Smith, Matthew R W; Wright, Ian M; Minshall, Gaynor J; Dudhia, Jay; Verheyen, Kristien; Heinegård, Dick LU and Smith, Roger LU (2011) In Veterinary surgery : VS : the official journal of the American College of Veterinary Surgeons Dec. p.54-58
Abstract
Objectives: To evaluate digital flexor tendon sheath (DFTS) synovial fluid cartilage oligomeric matrix protein (COMP) concentrations as a molecular marker for intrathecal pathology. Study Design: Case control study. Animals: Horses (n=46) with DFTS tenosynovitis; 23 fresh cadaver horses. Methods: DFTS synovial fluid samples were collected from clinical cases with noninfected DFTS tenosynovitis and from control DFTS. Clinical and surgical findings were recorded, and dissection of control limbs was performed to confirm the DFTS to be grossly normal. Synovial fluid COMP was quantified using a homologous competitive inhibition ELISA. Results: Abnormalities were identified tenoscopically: intrathecal tendon/ligament tearing was identified in 37... (More)
Objectives: To evaluate digital flexor tendon sheath (DFTS) synovial fluid cartilage oligomeric matrix protein (COMP) concentrations as a molecular marker for intrathecal pathology. Study Design: Case control study. Animals: Horses (n=46) with DFTS tenosynovitis; 23 fresh cadaver horses. Methods: DFTS synovial fluid samples were collected from clinical cases with noninfected DFTS tenosynovitis and from control DFTS. Clinical and surgical findings were recorded, and dissection of control limbs was performed to confirm the DFTS to be grossly normal. Synovial fluid COMP was quantified using a homologous competitive inhibition ELISA. Results: Abnormalities were identified tenoscopically: intrathecal tendon/ligament tearing was identified in 37 cases and 9 had other lesions. In control horses, synovial fluid COMP was higher in younger horses. Clinical cases with intrathecal tendon/ligament tearing had higher synovial fluid COMP than either clinical cases with other lesions, or controls. In horses ≥5 years old, the sensitivity and specificity of the assay was high for diagnosing intrathecal tendon/ligament tearing. Conclusions: COMP concentrations in DFTS synovial fluid were significantly greater than those in normal horses with noninfected tenosynovitis caused by intrathecal tendon/ligament tearing, but not by other lesions. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Veterinary surgery : VS : the official journal of the American College of Veterinary Surgeons
volume
Dec
pages
54 - 58
publisher
Wiley-Blackwell
external identifiers
  • wos:000285833600009
  • pmid:21077920
  • scopus:78650746465
ISSN
1532-950X
DOI
10.1111/j.1532-950X.2010.00751.x
language
English
LU publication?
yes
id
c2f69514-c905-4ac7-94b7-0977e0f1ce4c (old id 1731973)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21077920?dopt=Abstract
date added to LUP
2010-12-01 12:08:56
date last changed
2017-09-17 08:46:22
@article{c2f69514-c905-4ac7-94b7-0977e0f1ce4c,
  abstract     = {Objectives: To evaluate digital flexor tendon sheath (DFTS) synovial fluid cartilage oligomeric matrix protein (COMP) concentrations as a molecular marker for intrathecal pathology. Study Design: Case control study. Animals: Horses (n=46) with DFTS tenosynovitis; 23 fresh cadaver horses. Methods: DFTS synovial fluid samples were collected from clinical cases with noninfected DFTS tenosynovitis and from control DFTS. Clinical and surgical findings were recorded, and dissection of control limbs was performed to confirm the DFTS to be grossly normal. Synovial fluid COMP was quantified using a homologous competitive inhibition ELISA. Results: Abnormalities were identified tenoscopically: intrathecal tendon/ligament tearing was identified in 37 cases and 9 had other lesions. In control horses, synovial fluid COMP was higher in younger horses. Clinical cases with intrathecal tendon/ligament tearing had higher synovial fluid COMP than either clinical cases with other lesions, or controls. In horses ≥5 years old, the sensitivity and specificity of the assay was high for diagnosing intrathecal tendon/ligament tearing. Conclusions: COMP concentrations in DFTS synovial fluid were significantly greater than those in normal horses with noninfected tenosynovitis caused by intrathecal tendon/ligament tearing, but not by other lesions.},
  author       = {Smith, Matthew R W and Wright, Ian M and Minshall, Gaynor J and Dudhia, Jay and Verheyen, Kristien and Heinegård, Dick and Smith, Roger},
  issn         = {1532-950X},
  language     = {eng},
  pages        = {54--58},
  publisher    = {Wiley-Blackwell},
  series       = {Veterinary surgery : VS : the official journal of the American College of Veterinary Surgeons},
  title        = {Increased Cartilage Oligomeric Matrix Protein Concentrations in Equine Digital Flexor Tendon Sheath Synovial Fluid Predicts Intrathecal Tendon Damage.},
  url          = {http://dx.doi.org/10.1111/j.1532-950X.2010.00751.x},
  volume       = {Dec},
  year         = {2011},
}