System for interstitial photodynamic therapy with online dosimetry: first clinical experiences of prostate cancer.
(2010) In Journal of Biomedical Optics 15(5).- Abstract
- The first results from a clinical study for Temoporfin-mediated photodynamic therapy (PDT) of low-grade (T1c) primary prostate cancer using online dosimetry are presented. Dosimetric feedback in real time was applied, for the first time to our knowledge, in interstitial photodynamic therapy. The dosimetry software IDOSE provided dose plans, including optical fiber positions and light doses based on 3-D tissue models generated from ultrasound images. Tissue optical property measurements were obtained using the same fibers used for light delivery. Measurements were taken before, during, and after the treatment session. On the basis of these real-time measured optical properties, the light-dose plan was recalculated. The aim of the treatment... (More)
- The first results from a clinical study for Temoporfin-mediated photodynamic therapy (PDT) of low-grade (T1c) primary prostate cancer using online dosimetry are presented. Dosimetric feedback in real time was applied, for the first time to our knowledge, in interstitial photodynamic therapy. The dosimetry software IDOSE provided dose plans, including optical fiber positions and light doses based on 3-D tissue models generated from ultrasound images. Tissue optical property measurements were obtained using the same fibers used for light delivery. Measurements were taken before, during, and after the treatment session. On the basis of these real-time measured optical properties, the light-dose plan was recalculated. The aim of the treatment was to ablate the entire prostate while minimizing exposure to surrounding organs. The results indicate that online dosimetry based on real-time tissue optical property measurements enabled the light dose to be adapted and optimized. However, histopathological analysis of tissue biopsies taken six months post-PDT treatment showed there were still residual viable cancer cells present in the prostate tissue sections. The authors propose that the incomplete treatment of the prostate tissue could be due to a too low light threshold dose, which was set to 5 J∕cm2. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1732257
- author
- Swartling, Johannes ; Axelsson, Johan LU ; Ahlgren, Göran LU ; Kälkner, Karl Mikael ; Nilsson, Sten ; Svanberg, Sune ; Svanberg, Katarina LU and Andersson-Engels, Stefan
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Biomedical Optics
- volume
- 15
- issue
- 5
- article number
- 058003
- publisher
- SPIE
- external identifiers
-
- wos:000284837400057
- pmid:21054129
- scopus:79952505158
- pmid:21054129
- ISSN
- 1083-3668
- DOI
- 10.1117/1.3495720
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Atomic physics (011013005), Division of Geriatric Medicine (013040040), Oncology, MV (013035000), Pediatrics/Urology/Gynecology/Endocrinology (013240400)
- id
- 1375a9e5-defd-4b0a-9dec-ce8f49ebbb34 (old id 1732257)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21054129?dopt=Abstract
- date added to LUP
- 2016-04-04 08:01:09
- date last changed
- 2022-03-23 01:47:53
@article{1375a9e5-defd-4b0a-9dec-ce8f49ebbb34,
abstract = {{The first results from a clinical study for Temoporfin-mediated photodynamic therapy (PDT) of low-grade (T1c) primary prostate cancer using online dosimetry are presented. Dosimetric feedback in real time was applied, for the first time to our knowledge, in interstitial photodynamic therapy. The dosimetry software IDOSE provided dose plans, including optical fiber positions and light doses based on 3-D tissue models generated from ultrasound images. Tissue optical property measurements were obtained using the same fibers used for light delivery. Measurements were taken before, during, and after the treatment session. On the basis of these real-time measured optical properties, the light-dose plan was recalculated. The aim of the treatment was to ablate the entire prostate while minimizing exposure to surrounding organs. The results indicate that online dosimetry based on real-time tissue optical property measurements enabled the light dose to be adapted and optimized. However, histopathological analysis of tissue biopsies taken six months post-PDT treatment showed there were still residual viable cancer cells present in the prostate tissue sections. The authors propose that the incomplete treatment of the prostate tissue could be due to a too low light threshold dose, which was set to 5 J∕cm2.}},
author = {{Swartling, Johannes and Axelsson, Johan and Ahlgren, Göran and Kälkner, Karl Mikael and Nilsson, Sten and Svanberg, Sune and Svanberg, Katarina and Andersson-Engels, Stefan}},
issn = {{1083-3668}},
language = {{eng}},
number = {{5}},
publisher = {{SPIE}},
series = {{Journal of Biomedical Optics}},
title = {{System for interstitial photodynamic therapy with online dosimetry: first clinical experiences of prostate cancer.}},
url = {{https://lup.lub.lu.se/search/files/5162759/2371688.pdf}},
doi = {{10.1117/1.3495720}},
volume = {{15}},
year = {{2010}},
}