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System for interstitial photodynamic therapy with online dosimetry: first clinical experiences of prostate cancer.

Swartling, Johannes; Axelsson, Johan LU ; Ahlgren, Göran LU ; Kälkner, Karl Mikael; Nilsson, Sten; Svanberg, Sune; Svanberg, Katarina LU and Andersson-Engels, Stefan (2010) In Journal of Biomedical Optics 15(5).
Abstract
The first results from a clinical study for Temoporfin-mediated photodynamic therapy (PDT) of low-grade (T1c) primary prostate cancer using online dosimetry are presented. Dosimetric feedback in real time was applied, for the first time to our knowledge, in interstitial photodynamic therapy. The dosimetry software IDOSE provided dose plans, including optical fiber positions and light doses based on 3-D tissue models generated from ultrasound images. Tissue optical property measurements were obtained using the same fibers used for light delivery. Measurements were taken before, during, and after the treatment session. On the basis of these real-time measured optical properties, the light-dose plan was recalculated. The aim of the treatment... (More)
The first results from a clinical study for Temoporfin-mediated photodynamic therapy (PDT) of low-grade (T1c) primary prostate cancer using online dosimetry are presented. Dosimetric feedback in real time was applied, for the first time to our knowledge, in interstitial photodynamic therapy. The dosimetry software IDOSE provided dose plans, including optical fiber positions and light doses based on 3-D tissue models generated from ultrasound images. Tissue optical property measurements were obtained using the same fibers used for light delivery. Measurements were taken before, during, and after the treatment session. On the basis of these real-time measured optical properties, the light-dose plan was recalculated. The aim of the treatment was to ablate the entire prostate while minimizing exposure to surrounding organs. The results indicate that online dosimetry based on real-time tissue optical property measurements enabled the light dose to be adapted and optimized. However, histopathological analysis of tissue biopsies taken six months post-PDT treatment showed there were still residual viable cancer cells present in the prostate tissue sections. The authors propose that the incomplete treatment of the prostate tissue could be due to a too low light threshold dose, which was set to 5 J∕cm2. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
in
Journal of Biomedical Optics
volume
15
issue
5
publisher
Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society
external identifiers
  • wos:000284837400057
  • pmid:21054129
  • scopus:79952505158
ISSN
1083-3668
DOI
10.1117/1.3495720
language
English
LU publication?
yes
id
1375a9e5-defd-4b0a-9dec-ce8f49ebbb34 (old id 1732257)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21054129?dopt=Abstract
date added to LUP
2010-12-01 11:00:30
date last changed
2018-07-01 04:22:47
@article{1375a9e5-defd-4b0a-9dec-ce8f49ebbb34,
  abstract     = {The first results from a clinical study for Temoporfin-mediated photodynamic therapy (PDT) of low-grade (T1c) primary prostate cancer using online dosimetry are presented. Dosimetric feedback in real time was applied, for the first time to our knowledge, in interstitial photodynamic therapy. The dosimetry software IDOSE provided dose plans, including optical fiber positions and light doses based on 3-D tissue models generated from ultrasound images. Tissue optical property measurements were obtained using the same fibers used for light delivery. Measurements were taken before, during, and after the treatment session. On the basis of these real-time measured optical properties, the light-dose plan was recalculated. The aim of the treatment was to ablate the entire prostate while minimizing exposure to surrounding organs. The results indicate that online dosimetry based on real-time tissue optical property measurements enabled the light dose to be adapted and optimized. However, histopathological analysis of tissue biopsies taken six months post-PDT treatment showed there were still residual viable cancer cells present in the prostate tissue sections. The authors propose that the incomplete treatment of the prostate tissue could be due to a too low light threshold dose, which was set to 5 J∕cm2.},
  articleno    = {058003},
  author       = {Swartling, Johannes and Axelsson, Johan and Ahlgren, Göran and Kälkner, Karl Mikael and Nilsson, Sten and Svanberg, Sune and Svanberg, Katarina and Andersson-Engels, Stefan},
  issn         = {1083-3668},
  language     = {eng},
  number       = {5},
  publisher    = {Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society},
  series       = {Journal of Biomedical Optics},
  title        = {System for interstitial photodynamic therapy with online dosimetry: first clinical experiences of prostate cancer.},
  url          = {http://dx.doi.org/10.1117/1.3495720},
  volume       = {15},
  year         = {2010},
}