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Lipid-Block Copolymer-Immiscibility

Bryskhe, Karin; Schillén, Karin LU ; Löfroth, Jan-Erik and Olsson, Ulf LU (2001) In Physical Chemistry Chemical Physics 3. p.1303-1309
Abstract
We have investigated the binary system of a triblock copolymer of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO), EO5PO68EO5, in water. The ternary system with the same polymer, water and soybean phosphatidylcholine (lecithin) has also been studied. Small-angle X-ray scattering (SAXS), 2H NMR and differential scanning calorimetry (DSC) were used to characterize these systems. The phase diagram of the binary system is presented together with the characteristic parameters in the lamellar and hexagonal phases. In the ternary system, it was found that the lecithin and the block copolymer are essentially immiscible, forming separate phases. In a differential scanning calorimetry experiment it was found that the presence of the block... (More)
We have investigated the binary system of a triblock copolymer of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO), EO5PO68EO5, in water. The ternary system with the same polymer, water and soybean phosphatidylcholine (lecithin) has also been studied. Small-angle X-ray scattering (SAXS), 2H NMR and differential scanning calorimetry (DSC) were used to characterize these systems. The phase diagram of the binary system is presented together with the characteristic parameters in the lamellar and hexagonal phases. In the ternary system, it was found that the lecithin and the block copolymer are essentially immiscible, forming separate phases. In a differential scanning calorimetry experiment it was found that the presence of the block copolymer did not affect the melting temperature of dipalmitoyl phosphatidyl choline. Again indicating immiscibility. The alkane hexadecane is a bad solvent for polypropylene oxide at room temperature. We conclude that it is the difference in hydrophobicity (or polarity) of the hydrophobic parts of the lecithin (lipid) and the block copolymer that explains their immiscibility (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Physical Chemistry Chemical Physics
volume
3
pages
1303 - 1309
publisher
Royal Society of Chemistry
external identifiers
  • scopus:0035313037
ISSN
1463-9084
DOI
10.1039/B009487K
language
English
LU publication?
yes
id
46121658-11df-43bd-822f-e99e4f313999 (old id 1736867)
date added to LUP
2010-12-14 16:44:39
date last changed
2018-05-29 10:41:39
@article{46121658-11df-43bd-822f-e99e4f313999,
  abstract     = {We have investigated the binary system of a triblock copolymer of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO), EO5PO68EO5, in water. The ternary system with the same polymer, water and soybean phosphatidylcholine (lecithin) has also been studied. Small-angle X-ray scattering (SAXS), 2H NMR and differential scanning calorimetry (DSC) were used to characterize these systems. The phase diagram of the binary system is presented together with the characteristic parameters in the lamellar and hexagonal phases. In the ternary system, it was found that the lecithin and the block copolymer are essentially immiscible, forming separate phases. In a differential scanning calorimetry experiment it was found that the presence of the block copolymer did not affect the melting temperature of dipalmitoyl phosphatidyl choline. Again indicating immiscibility. The alkane hexadecane is a bad solvent for polypropylene oxide at room temperature. We conclude that it is the difference in hydrophobicity (or polarity) of the hydrophobic parts of the lecithin (lipid) and the block copolymer that explains their immiscibility},
  author       = {Bryskhe, Karin and Schillén, Karin and Löfroth, Jan-Erik and Olsson, Ulf},
  issn         = {1463-9084},
  language     = {eng},
  pages        = {1303--1309},
  publisher    = {Royal Society of Chemistry},
  series       = {Physical Chemistry Chemical Physics},
  title        = {Lipid-Block Copolymer-Immiscibility},
  url          = {http://dx.doi.org/10.1039/B009487K},
  volume       = {3},
  year         = {2001},
}