Lipid-Block Copolymer-Immiscibility
(2001) In Physical Chemistry Chemical Physics 3. p.1303-1309- Abstract
- We have investigated the binary system of a triblock copolymer of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO), EO5PO68EO5, in water. The ternary system with the same polymer, water and soybean phosphatidylcholine (lecithin) has also been studied. Small-angle X-ray scattering (SAXS), 2H NMR and differential scanning calorimetry (DSC) were used to characterize these systems. The phase diagram of the binary system is presented together with the characteristic parameters in the lamellar and hexagonal phases. In the ternary system, it was found that the lecithin and the block copolymer are essentially immiscible, forming separate phases. In a differential scanning calorimetry experiment it was found that the presence of the block... (More)
- We have investigated the binary system of a triblock copolymer of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO), EO5PO68EO5, in water. The ternary system with the same polymer, water and soybean phosphatidylcholine (lecithin) has also been studied. Small-angle X-ray scattering (SAXS), 2H NMR and differential scanning calorimetry (DSC) were used to characterize these systems. The phase diagram of the binary system is presented together with the characteristic parameters in the lamellar and hexagonal phases. In the ternary system, it was found that the lecithin and the block copolymer are essentially immiscible, forming separate phases. In a differential scanning calorimetry experiment it was found that the presence of the block copolymer did not affect the melting temperature of dipalmitoyl phosphatidyl choline. Again indicating immiscibility. The alkane hexadecane is a bad solvent for polypropylene oxide at room temperature. We conclude that it is the difference in hydrophobicity (or polarity) of the hydrophobic parts of the lecithin (lipid) and the block copolymer that explains their immiscibility (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1736867
- author
- Bryskhe, Karin ; Schillén, Karin LU ; Löfroth, Jan-Erik and Olsson, Ulf LU
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Physical Chemistry Chemical Physics
- volume
- 3
- pages
- 1303 - 1309
- publisher
- Royal Society of Chemistry
- external identifiers
-
- scopus:0035313037
- ISSN
- 1463-9084
- DOI
- 10.1039/B009487K
- language
- English
- LU publication?
- yes
- id
- 46121658-11df-43bd-822f-e99e4f313999 (old id 1736867)
- date added to LUP
- 2016-04-01 15:22:13
- date last changed
- 2022-01-28 04:59:43
@article{46121658-11df-43bd-822f-e99e4f313999, abstract = {{We have investigated the binary system of a triblock copolymer of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO), EO5PO68EO5, in water. The ternary system with the same polymer, water and soybean phosphatidylcholine (lecithin) has also been studied. Small-angle X-ray scattering (SAXS), 2H NMR and differential scanning calorimetry (DSC) were used to characterize these systems. The phase diagram of the binary system is presented together with the characteristic parameters in the lamellar and hexagonal phases. In the ternary system, it was found that the lecithin and the block copolymer are essentially immiscible, forming separate phases. In a differential scanning calorimetry experiment it was found that the presence of the block copolymer did not affect the melting temperature of dipalmitoyl phosphatidyl choline. Again indicating immiscibility. The alkane hexadecane is a bad solvent for polypropylene oxide at room temperature. We conclude that it is the difference in hydrophobicity (or polarity) of the hydrophobic parts of the lecithin (lipid) and the block copolymer that explains their immiscibility}}, author = {{Bryskhe, Karin and Schillén, Karin and Löfroth, Jan-Erik and Olsson, Ulf}}, issn = {{1463-9084}}, language = {{eng}}, pages = {{1303--1309}}, publisher = {{Royal Society of Chemistry}}, series = {{Physical Chemistry Chemical Physics}}, title = {{Lipid-Block Copolymer-Immiscibility}}, url = {{http://dx.doi.org/10.1039/B009487K}}, doi = {{10.1039/B009487K}}, volume = {{3}}, year = {{2001}}, }