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On the adaptive significance of stress-induced immunosuppression

Råberg, Lars LU ; Grahn, Mats LU ; Hasselquist, Dennis LU and Svensson, Erik LU (1998) In Royal Society of London. Proceedings B. Biological Sciences 265(1406). p.1637-1641
Abstract
We approach the field of stress immunology from an ecological point of view and ask: why should a heavy physical workload, for example as a result of a high reproductive effort, compromise immune function? We argue that immunosuppression by neuroendocrine mechanisms, such as stress hormones, during heavy physical workload is adaptive, and consider two different ultimate explanations of such immunosuppression. First, several authors have suggested that the immune system is suppressed to reallocate resources to other metabolic demands. In our view, this hypothesis assumes that considerable amounts of energy or nutrients can be saved by suppressing the immune system; however, this assumption requires further investigation. Second, we suggest... (More)
We approach the field of stress immunology from an ecological point of view and ask: why should a heavy physical workload, for example as a result of a high reproductive effort, compromise immune function? We argue that immunosuppression by neuroendocrine mechanisms, such as stress hormones, during heavy physical workload is adaptive, and consider two different ultimate explanations of such immunosuppression. First, several authors have suggested that the immune system is suppressed to reallocate resources to other metabolic demands. In our view, this hypothesis assumes that considerable amounts of energy or nutrients can be saved by suppressing the immune system; however, this assumption requires further investigation. Second, we suggest an alternative explanation based on the idea that the immune system is tightly regulated by neuroendocrine mechanisms to avoid hyperactivation and ensuing autoimmune responses. We hypothesize that the risk of autoimmune responses increases during heavy physical workload and that the immune system is suppressed to counteract this. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
immune-system, strenuous exercise, reproductive effort, pituitary-adrenal axis, exercise, strenuous, sexual selection, cost of reproduction, immunocompetence, autoimmunity, proteins, cost, recognition, hypotheses, endocrine
in
Royal Society of London. Proceedings B. Biological Sciences
volume
265
issue
1406
pages
1637 - 1641
publisher
Royal Society
external identifiers
  • scopus:0032494125
ISSN
1471-2954
DOI
10.1098/rspb.1998.0482
project
Costs of the immune system and maternal effects
language
English
LU publication?
yes
id
27fd84ba-24ab-429e-9b34-d7b3d4ffca00 (old id 1747724)
alternative location
http://www.jstor.org/stable/51135
date added to LUP
2011-02-22 12:18:47
date last changed
2017-10-22 04:37:07
@article{27fd84ba-24ab-429e-9b34-d7b3d4ffca00,
  abstract     = {We approach the field of stress immunology from an ecological point of view and ask: why should a heavy physical workload, for example as a result of a high reproductive effort, compromise immune function? We argue that immunosuppression by neuroendocrine mechanisms, such as stress hormones, during heavy physical workload is adaptive, and consider two different ultimate explanations of such immunosuppression. First, several authors have suggested that the immune system is suppressed to reallocate resources to other metabolic demands. In our view, this hypothesis assumes that considerable amounts of energy or nutrients can be saved by suppressing the immune system; however, this assumption requires further investigation. Second, we suggest an alternative explanation based on the idea that the immune system is tightly regulated by neuroendocrine mechanisms to avoid hyperactivation and ensuing autoimmune responses. We hypothesize that the risk of autoimmune responses increases during heavy physical workload and that the immune system is suppressed to counteract this.},
  author       = {Råberg, Lars and Grahn, Mats and Hasselquist, Dennis and Svensson, Erik},
  issn         = {1471-2954},
  keyword      = {immune-system,strenuous exercise,reproductive effort,pituitary-adrenal axis,exercise,strenuous,sexual selection,cost of reproduction,immunocompetence,autoimmunity,proteins,cost,recognition,hypotheses,endocrine},
  language     = {eng},
  number       = {1406},
  pages        = {1637--1641},
  publisher    = {Royal Society},
  series       = {Royal Society of London. Proceedings B. Biological Sciences},
  title        = {On the adaptive significance of stress-induced immunosuppression},
  url          = {http://dx.doi.org/10.1098/rspb.1998.0482},
  volume       = {265},
  year         = {1998},
}