Nuclear expression of the Non-B Cell Lineage Sox11 Transcription Factor Identifies Mantle Cell Lymphoma
Ek, Sara LU ; Dictor, Michael LU ; Jerkeman, Mats LU ; Jirström, Karin LU
and Borrebaeck, Carl
LU
(2008)
In Blood
111(2).
p.800-805
- Abstract
- Mantle cell lymphoma is defined pathologically by the detection of CD20, CD5 and most importantly cyclin D1 (CCND1). Its distinction from other lymphomas is important for prognosis and appropriate therapy but occasional cases may fail to express CCND1 and morphologic simulators may express CD20 and CD5 but not CD23. In this study, we
show that the transcription factor Sox11 is specifically expressed in the nucleus of mantle cell lymphoma (MCL) compared to other lymphomas and benign lymphoid tissue.
Although the role of Sox11 presently is not known in lymphocyte ontogeny it is normally expressed in the developing central nervous system in the embryo and shows sequence homology with Sox4, a transcription factor crucial for... (More) - Mantle cell lymphoma is defined pathologically by the detection of CD20, CD5 and most importantly cyclin D1 (CCND1). Its distinction from other lymphomas is important for prognosis and appropriate therapy but occasional cases may fail to express CCND1 and morphologic simulators may express CD20 and CD5 but not CD23. In this study, we
show that the transcription factor Sox11 is specifically expressed in the nucleus of mantle cell lymphoma (MCL) compared to other lymphomas and benign lymphoid tissue.
Although the role of Sox11 presently is not known in lymphocyte ontogeny it is normally expressed in the developing central nervous system in the embryo and shows sequence homology with Sox4, a transcription factor crucial for B lymphopoiesis. Sox11 mRNA is increased in gliomas compared to healthy brain tissue, suggesting a role in malignant transformation and/or cell survival. Our novel finding of specific overexpression of Sox11 mRNA and nuclear protein in both cyclin D1 positive and negative MCL, may be useful for the diagnosis of MCL as a complement to cyclin D1 and also suggests a functional role for Sox11 in MCL. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/593929
- author
- Ek, Sara
LU
; Dictor, Michael
LU
; Jerkeman, Mats
LU
; Jirström, Karin
LU
and Borrebaeck, Carl
LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Blood
- volume
- 111
- issue
- 2
- pages
- 800 - 805
- publisher
- American Society of Hematology
- external identifiers
-
- wos:000252458700054
- scopus:38349103985
- ISSN
- 1528-0020
- DOI
- 10.1182/blood-2007-06-093401
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Immunotechnology (011029300), Oncology, MV (013035000), Pathology, (Lund) (013030000), Pathology (Malmö) (013031000)
- id
- 174ef66e-1728-4aed-9531-0f98517409bb (old id 593929)
- date added to LUP
- 2016-04-01 12:25:06
- date last changed
- 2024-01-23 17:24:53
@article{174ef66e-1728-4aed-9531-0f98517409bb,
abstract = {{Mantle cell lymphoma is defined pathologically by the detection of CD20, CD5 and most importantly cyclin D1 (CCND1). Its distinction from other lymphomas is important for prognosis and appropriate therapy but occasional cases may fail to express CCND1 and morphologic simulators may express CD20 and CD5 but not CD23. In this study, we<br/><br>
show that the transcription factor Sox11 is specifically expressed in the nucleus of mantle cell lymphoma (MCL) compared to other lymphomas and benign lymphoid tissue.<br/><br>
Although the role of Sox11 presently is not known in lymphocyte ontogeny it is normally expressed in the developing central nervous system in the embryo and shows sequence homology with Sox4, a transcription factor crucial for B lymphopoiesis. Sox11 mRNA is increased in gliomas compared to healthy brain tissue, suggesting a role in malignant transformation and/or cell survival. Our novel finding of specific overexpression of Sox11 mRNA and nuclear protein in both cyclin D1 positive and negative MCL, may be useful for the diagnosis of MCL as a complement to cyclin D1 and also suggests a functional role for Sox11 in MCL.}},
author = {{Ek, Sara and Dictor, Michael and Jerkeman, Mats and Jirström, Karin and Borrebaeck, Carl}},
issn = {{1528-0020}},
language = {{eng}},
number = {{2}},
pages = {{800--805}},
publisher = {{American Society of Hematology}},
series = {{Blood}},
title = {{Nuclear expression of the Non-B Cell Lineage Sox11 Transcription Factor Identifies Mantle Cell Lymphoma}},
url = {{http://dx.doi.org/10.1182/blood-2007-06-093401}},
doi = {{10.1182/blood-2007-06-093401}},
volume = {{111}},
year = {{2008}},
}