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Hormonal and immune profiles in blood were unaffected by PHA provocation in suckling and weaning pigs

Prykhodko, Olena LU ; Fedkiv, Olexandr LU ; Pierzynowski, Stefan LU ; Svendsen, J. and Westrom, B. R. (2010) 11th International Symposium on Digestive Physiology of Pigs In Livestock Science 133(1-3). p.253-256
Abstract
The lectin, phytohaemagglutinin (PHA), from red kidney beans has been shown as an inducer of growth and precocious gastrointestinal (Cl) maturation in suckling animals, thus better preparing piglets for the weaning procedure. PHA exposure results in the release of gut peptide hormones and/or activation of the Cl immune system. The aim of this study was to elucidate the mechanisms of PHA provocation by studying changes in the blood/plasma levels of major gut hormones, immune parameters and acute phase proteins. Suckling, 9-10 day-old, littermate piglets were gavage fed PHA, either in purified or crude form or, as a control, alpha-lactalbumin (n = 5-6 pigs/group) and blood was obtained repeatedly during one week and after weaning at 5 weeks.... (More)
The lectin, phytohaemagglutinin (PHA), from red kidney beans has been shown as an inducer of growth and precocious gastrointestinal (Cl) maturation in suckling animals, thus better preparing piglets for the weaning procedure. PHA exposure results in the release of gut peptide hormones and/or activation of the Cl immune system. The aim of this study was to elucidate the mechanisms of PHA provocation by studying changes in the blood/plasma levels of major gut hormones, immune parameters and acute phase proteins. Suckling, 9-10 day-old, littermate piglets were gavage fed PHA, either in purified or crude form or, as a control, alpha-lactalbumin (n = 5-6 pigs/group) and blood was obtained repeatedly during one week and after weaning at 5 weeks. No significant differences in the blood parameters between PHA-treated pigs in comparison to their time-matched controls were found during the first week after treatment. At weaning significant changes in hormonal (insulin) and immune (WBC) parameters and CRP were observed, however, these effects were independent of earlier PHA treatment. In conclusion, PHA, given enterally as a single dose, did not affect the basal blood parameters analysed, during both the suckling and post-weaning periods in piglets. (C) 2010 Elsevier B.V. All rights reserved. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Inflammation, Phytohaemagglutinin, Weaning, Intestinal maturation, Piglets
in
Livestock Science
volume
133
issue
1-3
pages
253 - 256
publisher
Elsevier
conference name
11th International Symposium on Digestive Physiology of Pigs
external identifiers
  • wos:000284726000068
  • scopus:77957102804
ISSN
1871-1413
DOI
10.1016/j.livsci.2010.06.079
language
English
LU publication?
yes
id
ea6d9bbf-db1b-4317-84fa-cda58ab40adf (old id 1751645)
date added to LUP
2010-12-29 13:30:06
date last changed
2018-05-29 11:52:45
@inproceedings{ea6d9bbf-db1b-4317-84fa-cda58ab40adf,
  abstract     = {The lectin, phytohaemagglutinin (PHA), from red kidney beans has been shown as an inducer of growth and precocious gastrointestinal (Cl) maturation in suckling animals, thus better preparing piglets for the weaning procedure. PHA exposure results in the release of gut peptide hormones and/or activation of the Cl immune system. The aim of this study was to elucidate the mechanisms of PHA provocation by studying changes in the blood/plasma levels of major gut hormones, immune parameters and acute phase proteins. Suckling, 9-10 day-old, littermate piglets were gavage fed PHA, either in purified or crude form or, as a control, alpha-lactalbumin (n = 5-6 pigs/group) and blood was obtained repeatedly during one week and after weaning at 5 weeks. No significant differences in the blood parameters between PHA-treated pigs in comparison to their time-matched controls were found during the first week after treatment. At weaning significant changes in hormonal (insulin) and immune (WBC) parameters and CRP were observed, however, these effects were independent of earlier PHA treatment. In conclusion, PHA, given enterally as a single dose, did not affect the basal blood parameters analysed, during both the suckling and post-weaning periods in piglets. (C) 2010 Elsevier B.V. All rights reserved.},
  author       = {Prykhodko, Olena and Fedkiv, Olexandr and Pierzynowski, Stefan and Svendsen, J. and Westrom, B. R.},
  booktitle    = {Livestock Science},
  issn         = {1871-1413},
  keyword      = {Inflammation,Phytohaemagglutinin,Weaning,Intestinal maturation,Piglets},
  language     = {eng},
  number       = {1-3},
  pages        = {253--256},
  publisher    = {Elsevier},
  title        = {Hormonal and immune profiles in blood were unaffected by PHA provocation in suckling and weaning pigs},
  url          = {http://dx.doi.org/10.1016/j.livsci.2010.06.079},
  volume       = {133},
  year         = {2010},
}