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Interaction between amphiphilic peptides and phospholipid membranes

Stromstedt, Adam A.; Ringstad, Lovisa; Schmidtchen, Artur LU and Malmsten, Martin (2010) In Current Opinion in Colloid & Interface Science 15(6). p.467-478
Abstract
This brief review aims at providing some illustrative examples on the interaction between amphiphilic peptides and phospholipid membranes an area of significant current interest Focusing on antimicrobial peptides factors affecting peptide-membrane interactions are addressed including effects of peptide length charge hydrophobicity secondary structure and topology Effects of membrane composition are also illustrated including effects of membrane charge nature of the polar headgroup and presence of cholesterol and other sterols Throughout novel insights on the importance of peptide adsorption density on membrane stability are emphasized as is the correlation between peptide adsorption peptide induced leakage in model liposome systems... (More)
This brief review aims at providing some illustrative examples on the interaction between amphiphilic peptides and phospholipid membranes an area of significant current interest Focusing on antimicrobial peptides factors affecting peptide-membrane interactions are addressed including effects of peptide length charge hydrophobicity secondary structure and topology Effects of membrane composition are also illustrated including effects of membrane charge nature of the polar headgroup and presence of cholesterol and other sterols Throughout novel insights on the importance of peptide adsorption density on membrane stability are emphasized as is the correlation between peptide adsorption peptide induced leakage in model liposome systems peptide-induced lysis of bacteria and bacteria killing (C) 2010 Elsevier Ltd All rights reserved (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Liposome, Bacteria, AMP, Antimicrobial peptide, Membrane
in
Current Opinion in Colloid & Interface Science
volume
15
issue
6
pages
467 - 478
publisher
Elsevier
external identifiers
  • wos:000284520000009
  • scopus:77957960555
ISSN
1359-0294
DOI
10.1016/j.cocis.2010.05.006
language
English
LU publication?
yes
id
ef75d5b2-538f-4fd9-bd60-c61dd202672a (old id 1752253)
date added to LUP
2011-01-04 07:36:07
date last changed
2018-07-08 03:35:48
@article{ef75d5b2-538f-4fd9-bd60-c61dd202672a,
  abstract     = {This brief review aims at providing some illustrative examples on the interaction between amphiphilic peptides and phospholipid membranes an area of significant current interest Focusing on antimicrobial peptides factors affecting peptide-membrane interactions are addressed including effects of peptide length charge hydrophobicity secondary structure and topology Effects of membrane composition are also illustrated including effects of membrane charge nature of the polar headgroup and presence of cholesterol and other sterols Throughout novel insights on the importance of peptide adsorption density on membrane stability are emphasized as is the correlation between peptide adsorption peptide induced leakage in model liposome systems peptide-induced lysis of bacteria and bacteria killing (C) 2010 Elsevier Ltd All rights reserved},
  author       = {Stromstedt, Adam A. and Ringstad, Lovisa and Schmidtchen, Artur and Malmsten, Martin},
  issn         = {1359-0294},
  keyword      = {Liposome,Bacteria,AMP,Antimicrobial peptide,Membrane},
  language     = {eng},
  number       = {6},
  pages        = {467--478},
  publisher    = {Elsevier},
  series       = {Current Opinion in Colloid & Interface Science},
  title        = {Interaction between amphiphilic peptides and phospholipid membranes},
  url          = {http://dx.doi.org/10.1016/j.cocis.2010.05.006},
  volume       = {15},
  year         = {2010},
}