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A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)

Enciso-Mora, Victor; Broderick, Peter; Ma, Yussanne; Jarrett, Ruth F.; Hjalgrim, Henrik; Hemminki, Kari LU ; van den Berg, Anke; Olver, Bianca; Lloyd, Amy and Dobbins, Sara E., et al. (2010) In Nature Genetics 42(12). p.1126-1126
Abstract
To identify susceptibility loci for classical Hodgkin's lymphoma (cHL), we conducted a genome-wide association study of 589 individuals with cHL (cases) and 5,199 controls with validation in four independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL, odds ratio (OR) = 1.22, combined P = 1.91 x 10(-8)), 8q24.21 (rs2019960, PVT1, OR = 1.33, combined P = 1.26 x 10(-13)) and 10p14 (rs501764, GATA3, OR = 1.25, combined P = 7.05 x 10(-8)). Furthermore, we confirmed the role of the major histocompatibility complex in disease etiology by revealing a strong human leukocyte antigen (HLA) association (rs6903608, OR = 1.70, combined P = 2.84 x 10(-50)). These data provide new... (More)
To identify susceptibility loci for classical Hodgkin's lymphoma (cHL), we conducted a genome-wide association study of 589 individuals with cHL (cases) and 5,199 controls with validation in four independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL, odds ratio (OR) = 1.22, combined P = 1.91 x 10(-8)), 8q24.21 (rs2019960, PVT1, OR = 1.33, combined P = 1.26 x 10(-13)) and 10p14 (rs501764, GATA3, OR = 1.25, combined P = 7.05 x 10(-8)). Furthermore, we confirmed the role of the major histocompatibility complex in disease etiology by revealing a strong human leukocyte antigen (HLA) association (rs6903608, OR = 1.70, combined P = 2.84 x 10(-50)). These data provide new insight into the pathogenesis of cHL. (Less)
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Nature Genetics
volume
42
issue
12
pages
1126 - 1126
publisher
Nature Publishing Group
external identifiers
  • wos:000284578800017
  • scopus:78649471895
ISSN
1546-1718
DOI
10.1038/ng.696
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English
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yes
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70404b76-c913-4826-923b-78df89ad112d (old id 1752366)
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2011-01-04 07:34:01
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@article{70404b76-c913-4826-923b-78df89ad112d,
  abstract     = {To identify susceptibility loci for classical Hodgkin's lymphoma (cHL), we conducted a genome-wide association study of 589 individuals with cHL (cases) and 5,199 controls with validation in four independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL, odds ratio (OR) = 1.22, combined P = 1.91 x 10(-8)), 8q24.21 (rs2019960, PVT1, OR = 1.33, combined P = 1.26 x 10(-13)) and 10p14 (rs501764, GATA3, OR = 1.25, combined P = 7.05 x 10(-8)). Furthermore, we confirmed the role of the major histocompatibility complex in disease etiology by revealing a strong human leukocyte antigen (HLA) association (rs6903608, OR = 1.70, combined P = 2.84 x 10(-50)). These data provide new insight into the pathogenesis of cHL.},
  author       = {Enciso-Mora, Victor and Broderick, Peter and Ma, Yussanne and Jarrett, Ruth F. and Hjalgrim, Henrik and Hemminki, Kari and van den Berg, Anke and Olver, Bianca and Lloyd, Amy and Dobbins, Sara E. and Lightfoot, Tracy and van Leeuwen, Flora E. and Foersti, Asta and Diepstra, Arjan and Broeks, Annegien and Vijayakrishnan, Jayaram and Shield, Lesley and Lake, Annette and Montgomery, Dorothy and Roman, Eve and Engert, Andreas and von Strandmann, Elke Pogge and Reiners, Katrin S. and Nolte, Ilja M. and Smedby, Karin E. and Adami, Hans-Olov and Russell, Nicola S. and Glimelius, Bengt and Hamilton-Dutoit, Stephen and de Bruin, Marieke and Ryder, Lars P. and Molin, Daniel and Sorensen, Karina Meden and Chang, Ellen T. and Taylor, Malcolm and Cooke, Rosie and Hofstra, Robert and Westers, Helga and van Wezel, Tom and van Eijk, Ronald and Ashworth, Alan and Rostgaard, Klaus and Melbye, Mads and Swerdlow, Anthony J. and Houlston, Richard S.},
  issn         = {1546-1718},
  language     = {eng},
  number       = {12},
  pages        = {1126--1126},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)},
  url          = {http://dx.doi.org/10.1038/ng.696},
  volume       = {42},
  year         = {2010},
}