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The small RNA miR-375 - a pancreatic islet abundant miRNA with multiple roles in endocrine beta cell function

Eliasson, Lena LU orcid (2017) In Molecular and Cellular Endocrinology 456. p.95-101
Abstract

The pathophysiology of diabetes is complex and recent research put focus on the pancreatic islets of Langerhans and the insulin-secreting beta cells as central in the development of the disease. MicroRNAs (miRNAs), the small non-coding RNAs regulating post-transcriptional gene expression, are significant regulators of beta cell function. One of the most abundant miRNAs in the islets is miR-375. This review focus on the role of miR-375 in beta cell function, including effects in development and differentiation, proliferation and regulation of insulin secretion. It also discusses the regulation of miR-375 expression, miR-375 as a potential circulating biomarker in type 1 and type 2 diabetes, and the need for the beta cell to keep... (More)

The pathophysiology of diabetes is complex and recent research put focus on the pancreatic islets of Langerhans and the insulin-secreting beta cells as central in the development of the disease. MicroRNAs (miRNAs), the small non-coding RNAs regulating post-transcriptional gene expression, are significant regulators of beta cell function. One of the most abundant miRNAs in the islets is miR-375. This review focus on the role of miR-375 in beta cell function, including effects in development and differentiation, proliferation and regulation of insulin secretion. It also discusses the regulation of miR-375 expression, miR-375 as a potential circulating biomarker in type 1 and type 2 diabetes, and the need for the beta cell to keep expression of miR-375 within optimal levels. The summed picture of miR-375 is a miRNA with multiple functions with importance in the formation of beta cell identity, control of beta cell mass and regulation of insulin secretion.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Beta cell, Diabetes, Differentiation, Insulin, Insulin secretion, Islet of langerhans, MicroRNA, MiR-375, Proliferation
in
Molecular and Cellular Endocrinology
volume
456
pages
95 - 101
publisher
Elsevier
external identifiers
  • pmid:28254488
  • wos:000412250600011
  • scopus:85014520847
ISSN
0303-7207
DOI
10.1016/j.mce.2017.02.043
language
English
LU publication?
yes
id
175260eb-46fd-4a8b-a940-ce7ddc02b1a6
date added to LUP
2017-03-15 12:09:46
date last changed
2025-01-07 09:40:00
@article{175260eb-46fd-4a8b-a940-ce7ddc02b1a6,
  abstract     = {{<p>The pathophysiology of diabetes is complex and recent research put focus on the pancreatic islets of Langerhans and the insulin-secreting beta cells as central in the development of the disease. MicroRNAs (miRNAs), the small non-coding RNAs regulating post-transcriptional gene expression, are significant regulators of beta cell function. One of the most abundant miRNAs in the islets is miR-375. This review focus on the role of miR-375 in beta cell function, including effects in development and differentiation, proliferation and regulation of insulin secretion. It also discusses the regulation of miR-375 expression, miR-375 as a potential circulating biomarker in type 1 and type 2 diabetes, and the need for the beta cell to keep expression of miR-375 within optimal levels. The summed picture of miR-375 is a miRNA with multiple functions with importance in the formation of beta cell identity, control of beta cell mass and regulation of insulin secretion.</p>}},
  author       = {{Eliasson, Lena}},
  issn         = {{0303-7207}},
  keywords     = {{Beta cell; Diabetes; Differentiation; Insulin; Insulin secretion; Islet of langerhans; MicroRNA; MiR-375; Proliferation}},
  language     = {{eng}},
  month        = {{02}},
  pages        = {{95--101}},
  publisher    = {{Elsevier}},
  series       = {{Molecular and Cellular Endocrinology}},
  title        = {{The small RNA miR-375 - a pancreatic islet abundant miRNA with multiple roles in endocrine beta cell function}},
  url          = {{http://dx.doi.org/10.1016/j.mce.2017.02.043}},
  doi          = {{10.1016/j.mce.2017.02.043}},
  volume       = {{456}},
  year         = {{2017}},
}