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The growth of exocrine pancreatic insufficient young pigs fed an elemental diet is dependent on enteral pancreatin supplementation

Rengman, Sofia LU ; Fedkiv, Olexandr LU ; Botermans, Jos; Svendsen, Jorgen; Weström, Björn LU and Pierzynowski, Stefan LU (2010) 11th International Symposium on Digestive Physiology of Pigs In Livestock Science 134(1-3). p.50-52
Abstract
Young exocrine pancreas insufficient (EPI) pigs given a commercial feed (polymeric diet) show growth retardation that can be reversed by dietary supplementation with pancreatic enzymes. Our aim was to investigate if providing an elemental diet, mimicking a pre-digested diet, can support body growth in EPI-pigs. Thus, EPI-pigs, pancreatic duct-ligated at 12.2 +/- 2.6 weeks of age (15.3 +/- 4.8 kg), were fed for 6 days either a commercial polymeric pig feed or infused i.v. with an elemental diet, with or without oral supplementation with a porcine enzyme preparation (Creon (R)). The body weight (BW) gain was then compared at day 7. Control pigs (with intact pancreata) showed a 14.0 +/- 1.3% increase in BW independent of the diet, while... (More)
Young exocrine pancreas insufficient (EPI) pigs given a commercial feed (polymeric diet) show growth retardation that can be reversed by dietary supplementation with pancreatic enzymes. Our aim was to investigate if providing an elemental diet, mimicking a pre-digested diet, can support body growth in EPI-pigs. Thus, EPI-pigs, pancreatic duct-ligated at 12.2 +/- 2.6 weeks of age (15.3 +/- 4.8 kg), were fed for 6 days either a commercial polymeric pig feed or infused i.v. with an elemental diet, with or without oral supplementation with a porcine enzyme preparation (Creon (R)). The body weight (BW) gain was then compared at day 7. Control pigs (with intact pancreata) showed a 14.0 +/- 1.3% increase in BW independent of the diet, while EPI-pigs given the same diets either lost (polymeric diet) or slightly increased (elemental diet) their BW. In contrast, EPI-pigs fed the polymeric feed with Creon supplementation showed a normalised growth and EPI-pigs given the elemental diet with Creon supplementation gained 8.5 +/- 0.7% in BW. In conclusion, control pigs maintained a normal growth, independently of the diet being given in polymeric or elemental form, while EPI-pigs showed an impaired growth when receiving the same diets without oral enzyme supplementation. This suggests that pancreatic juice or enzyme preparations, in addition to their digestive properties, stimulate nutrient assimilation and anabolic processes in young fast-growing pigs. (C) 2010 Elsevier B.V. All rights reserved. (Less)
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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Elemental diet, Pancreatic enzymes, Pancreatic duct ligation, Polymeric, diet
in
Livestock Science
volume
134
issue
1-3
pages
50 - 52
publisher
Elsevier
conference name
11th International Symposium on Digestive Physiology of Pigs
external identifiers
  • wos:000284025800015
  • scopus:77957135955
ISSN
1871-1413
DOI
10.1016/j.livsci.2010.06.094
language
English
LU publication?
yes
id
af64c9f2-32e0-4222-9756-6faaba11bca9 (old id 1753111)
date added to LUP
2010-12-29 14:45:12
date last changed
2018-05-29 11:31:55
@inproceedings{af64c9f2-32e0-4222-9756-6faaba11bca9,
  abstract     = {Young exocrine pancreas insufficient (EPI) pigs given a commercial feed (polymeric diet) show growth retardation that can be reversed by dietary supplementation with pancreatic enzymes. Our aim was to investigate if providing an elemental diet, mimicking a pre-digested diet, can support body growth in EPI-pigs. Thus, EPI-pigs, pancreatic duct-ligated at 12.2 +/- 2.6 weeks of age (15.3 +/- 4.8 kg), were fed for 6 days either a commercial polymeric pig feed or infused i.v. with an elemental diet, with or without oral supplementation with a porcine enzyme preparation (Creon (R)). The body weight (BW) gain was then compared at day 7. Control pigs (with intact pancreata) showed a 14.0 +/- 1.3% increase in BW independent of the diet, while EPI-pigs given the same diets either lost (polymeric diet) or slightly increased (elemental diet) their BW. In contrast, EPI-pigs fed the polymeric feed with Creon supplementation showed a normalised growth and EPI-pigs given the elemental diet with Creon supplementation gained 8.5 +/- 0.7% in BW. In conclusion, control pigs maintained a normal growth, independently of the diet being given in polymeric or elemental form, while EPI-pigs showed an impaired growth when receiving the same diets without oral enzyme supplementation. This suggests that pancreatic juice or enzyme preparations, in addition to their digestive properties, stimulate nutrient assimilation and anabolic processes in young fast-growing pigs. (C) 2010 Elsevier B.V. All rights reserved.},
  author       = {Rengman, Sofia and Fedkiv, Olexandr and Botermans, Jos and Svendsen, Jorgen and Weström, Björn and Pierzynowski, Stefan},
  booktitle    = {Livestock Science},
  issn         = {1871-1413},
  keyword      = {Elemental diet,Pancreatic enzymes,Pancreatic duct ligation,Polymeric,diet},
  language     = {eng},
  number       = {1-3},
  pages        = {50--52},
  publisher    = {Elsevier},
  title        = {The growth of exocrine pancreatic insufficient young pigs fed an elemental diet is dependent on enteral pancreatin supplementation},
  url          = {http://dx.doi.org/10.1016/j.livsci.2010.06.094},
  volume       = {134},
  year         = {2010},
}