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Determinants of urinary pesticide metabolite concentrations in school-aged children from rural Bogotá, Colombia

Benavides-Piracón, John Alexander ; Hernández-Bonilla, David ; Menezes-Filho, José Antonio ; van Wendel de Joode, Berna ; Varela-Martínez, Diana Angelica ; Riaño-Herrera, Diego Alejandro ; Bahia, Thereza Christina ; Hidalgo-Mojica, Margarita ; Quintana-Cortés, Mónica Alejandra and Molina-Achury, Nancy Jeanet , et al. (2025) In ACTA Paulista de Enfermagem 30(5).
Abstract

This study aimed to determine urine pesticide metabolite concentrations using liquid chromatography and investigate associated exposure factors in a rural area of Bogotá, Colombia. In 2019, 231 urine samples were collected from children aged 7 to 10. Urinary pesticide metabolite concentrations were measured, and a questionnaire was administered to the children’s mothers to collect exposure-related data. Multiple linear regression with log10-transformed concentrations was utilized to identify factors influencing these concentrations. Thirteen pesticide metabolites were detected in urine samples. The highest concentrations were observed in chlorpyrifos (TCP= 1.48 median IQ (0.57-3.5)) and pyrimethanil (2.73 median IQ (4.56 7.67)). Log-10... (More)

This study aimed to determine urine pesticide metabolite concentrations using liquid chromatography and investigate associated exposure factors in a rural area of Bogotá, Colombia. In 2019, 231 urine samples were collected from children aged 7 to 10. Urinary pesticide metabolite concentrations were measured, and a questionnaire was administered to the children’s mothers to collect exposure-related data. Multiple linear regression with log10-transformed concentrations was utilized to identify factors influencing these concentrations. Thirteen pesticide metabolites were detected in urine samples. The highest concentrations were observed in chlorpyrifos (TCP= 1.48 median IQ (0.57-3.5)) and pyrimethanil (2.73 median IQ (4.56 7.67)). Log-10 transformed metabolites of chlorpyrifos and profenophos were positively associated with maternal pesticide use (β = 0.13, 95%CI 0.04-0.2) and (β: 0.16 95%CI 0.0-0.3), respectively. In conclusion, this study unveiled widespread exposure to multiple pesticides and determined that pesticide concentrations in urine samples were influenced by both para-occupational and environmental exposure factors among schoolchildren.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biomarkers, Exposure, Pesticide, Rural area, School-aged children
in
ACTA Paulista de Enfermagem
volume
30
issue
5
article number
e16992023
publisher
Departamento de Enfermagem/Universidade Federal de Sao Paulo
external identifiers
  • scopus:105007294064
  • pmid:40465932
ISSN
0103-2100
DOI
10.1590/1413-81232025305.16992023
language
English
LU publication?
yes
id
1755b6d3-f333-4cfb-b441-622f66017f93
date added to LUP
2026-01-12 12:52:30
date last changed
2026-01-13 02:15:44
@article{1755b6d3-f333-4cfb-b441-622f66017f93,
  abstract     = {{<p>This study aimed to determine urine pesticide metabolite concentrations using liquid chromatography and investigate associated exposure factors in a rural area of Bogotá, Colombia. In 2019, 231 urine samples were collected from children aged 7 to 10. Urinary pesticide metabolite concentrations were measured, and a questionnaire was administered to the children’s mothers to collect exposure-related data. Multiple linear regression with log10-transformed concentrations was utilized to identify factors influencing these concentrations. Thirteen pesticide metabolites were detected in urine samples. The highest concentrations were observed in chlorpyrifos (TCP= 1.48 median IQ (0.57-3.5)) and pyrimethanil (2.73 median IQ (4.56 7.67)). Log-10 transformed metabolites of chlorpyrifos and profenophos were positively associated with maternal pesticide use (β = 0.13, 95%CI 0.04-0.2) and (β: 0.16 95%CI 0.0-0.3), respectively. In conclusion, this study unveiled widespread exposure to multiple pesticides and determined that pesticide concentrations in urine samples were influenced by both para-occupational and environmental exposure factors among schoolchildren.</p>}},
  author       = {{Benavides-Piracón, John Alexander and Hernández-Bonilla, David and Menezes-Filho, José Antonio and van Wendel de Joode, Berna and Varela-Martínez, Diana Angelica and Riaño-Herrera, Diego Alejandro and Bahia, Thereza Christina and Hidalgo-Mojica, Margarita and Quintana-Cortés, Mónica Alejandra and Molina-Achury, Nancy Jeanet and Lind, Christian H. and Moya Muñoz, Iris Andrea}},
  issn         = {{0103-2100}},
  keywords     = {{Biomarkers; Exposure; Pesticide; Rural area; School-aged children}},
  language     = {{eng}},
  number       = {{5}},
  publisher    = {{Departamento de Enfermagem/Universidade Federal de Sao Paulo}},
  series       = {{ACTA Paulista de Enfermagem}},
  title        = {{Determinants of urinary pesticide metabolite concentrations in school-aged children from rural Bogotá, Colombia}},
  url          = {{http://dx.doi.org/10.1590/1413-81232025305.16992023}},
  doi          = {{10.1590/1413-81232025305.16992023}},
  volume       = {{30}},
  year         = {{2025}},
}