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The Functional Polymorphism 844 A>G in Fc{alpha}RI (CD89) Does Not Contribute to Systemic Sclerosis or Rheumatoid Arthritis Susceptibility.

Broen, Jasper C A; Coenen, Marieke J H; Rueda, Blanca; Witte, Torsten; Padyukov, Leonid; Klareskog, Lars; Hesselstrand, Roger LU ; Wuttge, Dirk LU ; Simeon, Carmen and Ortego-Centeno, Norberto, et al. (2011) In Journal of Rheumatology 38(3). p.446-449
Abstract
OBJECTIVE: To investigate the role of the Fc(α)RI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility. METHODS: The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The Fc(α)RI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing. RESULTS: We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results. CONCLUSION: Our data show that the Fc(α)RI 844 A>G polymorphism is not associated with SSc or RA susceptibility.
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Contribution to journal
publication status
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in
Journal of Rheumatology
volume
38
issue
3
pages
446 - 449
publisher
J Rheumatol Publ Co
external identifiers
  • wos:000288770700009
  • pmid:21159834
  • scopus:79952395833
ISSN
0315-162X
DOI
10.3899/jrheum.100427
language
English
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yes
id
1ab2ba5c-994a-4e30-b59c-5bac837d9d58 (old id 1756290)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21159834?dopt=Abstract
date added to LUP
2011-01-03 15:49:54
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2017-01-01 03:48:38
@article{1ab2ba5c-994a-4e30-b59c-5bac837d9d58,
  abstract     = {OBJECTIVE: To investigate the role of the Fc(α)RI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility. METHODS: The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The Fc(α)RI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing. RESULTS: We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results. CONCLUSION: Our data show that the Fc(α)RI 844 A>G polymorphism is not associated with SSc or RA susceptibility.},
  author       = {Broen, Jasper C A and Coenen, Marieke J H and Rueda, Blanca and Witte, Torsten and Padyukov, Leonid and Klareskog, Lars and Hesselstrand, Roger and Wuttge, Dirk and Simeon, Carmen and Ortego-Centeno, Norberto and González-Gay, Miguel and Pros, Anna and Hunzelman, Nicholas and Riemekasten, Gabriela and Kreuter, Alexander and Vonk, Madelon and Scorza, Rafaella and Beretta, Lorenzo and Airò, Paulo and van Riel, Piet L C M and Kimberly, Robert and Martin, Javier and Edberg, Jeffrey and Radstake, Timothy R D J},
  issn         = {0315-162X},
  language     = {eng},
  number       = {3},
  pages        = {446--449},
  publisher    = {J Rheumatol Publ Co},
  series       = {Journal of Rheumatology},
  title        = {The Functional Polymorphism 844 A>G in Fc{alpha}RI (CD89) Does Not Contribute to Systemic Sclerosis or Rheumatoid Arthritis Susceptibility.},
  url          = {http://dx.doi.org/10.3899/jrheum.100427},
  volume       = {38},
  year         = {2011},
}