The Functional Polymorphism 844 A>G in Fc{alpha}RI (CD89) Does Not Contribute to Systemic Sclerosis or Rheumatoid Arthritis Susceptibility.
(2011) In Journal of Rheumatology 38(3). p.446-449- Abstract
- OBJECTIVE: To investigate the role of the Fc(α)RI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility. METHODS: The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The Fc(α)RI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing. RESULTS: We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results. CONCLUSION: Our data show that the Fc(α)RI 844 A>G polymorphism is not associated with SSc or RA susceptibility.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1756290
- author
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Rheumatology
- volume
- 38
- issue
- 3
- pages
- 446 - 449
- publisher
- Journal of Rheumatology Publishing Company Limited
- external identifiers
-
- wos:000288770700009
- pmid:21159834
- scopus:79952395833
- pmid:21159834
- ISSN
- 0315-162X
- DOI
- 10.3899/jrheum.100427
- language
- English
- LU publication?
- yes
- id
- 1ab2ba5c-994a-4e30-b59c-5bac837d9d58 (old id 1756290)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21159834?dopt=Abstract
- date added to LUP
- 2016-04-01 10:41:09
- date last changed
- 2022-01-26 01:30:16
@article{1ab2ba5c-994a-4e30-b59c-5bac837d9d58, abstract = {{OBJECTIVE: To investigate the role of the Fc(α)RI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility. METHODS: The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The Fc(α)RI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing. RESULTS: We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results. CONCLUSION: Our data show that the Fc(α)RI 844 A>G polymorphism is not associated with SSc or RA susceptibility.}}, author = {{Broen, Jasper C A and Coenen, Marieke J H and Rueda, Blanca and Witte, Torsten and Padyukov, Leonid and Klareskog, Lars and Hesselstrand, Roger and Wuttge, Dirk and Simeon, Carmen and Ortego-Centeno, Norberto and González-Gay, Miguel and Pros, Anna and Hunzelman, Nicholas and Riemekasten, Gabriela and Kreuter, Alexander and Vonk, Madelon and Scorza, Rafaella and Beretta, Lorenzo and Airò, Paulo and van Riel, Piet L C M and Kimberly, Robert and Martin, Javier and Edberg, Jeffrey and Radstake, Timothy R D J}}, issn = {{0315-162X}}, language = {{eng}}, number = {{3}}, pages = {{446--449}}, publisher = {{Journal of Rheumatology Publishing Company Limited}}, series = {{Journal of Rheumatology}}, title = {{The Functional Polymorphism 844 A>G in Fc{alpha}RI (CD89) Does Not Contribute to Systemic Sclerosis or Rheumatoid Arthritis Susceptibility.}}, url = {{http://dx.doi.org/10.3899/jrheum.100427}}, doi = {{10.3899/jrheum.100427}}, volume = {{38}}, year = {{2011}}, }