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Bacterial outer membrane vesicles in disease and preventive medicine.

Ünal, Can LU ; Schaar, Viveka LU and Riesbeck, Kristian LU (2011) In Seminars in Immunopathology 33. p.395-408
Abstract
Gram-negative bacteria have the ability to produce outer membrane-derived vesicles (OMVs) that are released into the extracellular milieu. Even though this intriguing phenomenon is well-known since many years, various aspects of bacterial OMVs are not fully described and are still in the process of being characterized in detail. One major reason for this is that depending on the bacterial species and its respective ecological niche, OMVs exhibit an enormous functional diversity. Research of the past years has clearly shown that OMVs of many pathogenic bacteria contribute to the virulence potential by enriching virulence factors and delivering them over long distances, superseding direct bacterial contact with their host. The subsequent... (More)
Gram-negative bacteria have the ability to produce outer membrane-derived vesicles (OMVs) that are released into the extracellular milieu. Even though this intriguing phenomenon is well-known since many years, various aspects of bacterial OMVs are not fully described and are still in the process of being characterized in detail. One major reason for this is that depending on the bacterial species and its respective ecological niche, OMVs exhibit an enormous functional diversity. Research of the past years has clearly shown that OMVs of many pathogenic bacteria contribute to the virulence potential by enriching virulence factors and delivering them over long distances, superseding direct bacterial contact with their host. The subsequent interaction of OMVs with the host can occur at different levels regarding the type of immune response or the target cell type and may lead to different outcomes ranging from non-immunogenic activation or a pro-inflammatory response to cytotoxicity. In contrast to being virulence factors, OMVs are used for vaccination purposes in the combat against bacterial pathogens, and recent research thus is focused on to indirectly aim these versatile bacterial weapons against themselves. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Seminars in Immunopathology
volume
33
pages
395 - 408
publisher
Springer
external identifiers
  • wos:000295086500002
  • pmid:21153593
  • scopus:78649767939
ISSN
1863-2300
DOI
10.1007/s00281-010-0231-y
language
English
LU publication?
yes
id
1e4e1993-555a-484a-be41-39b4ea66fc55 (old id 1756452)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21153593?dopt=Abstract
date added to LUP
2011-01-03 15:01:48
date last changed
2017-08-27 05:42:36
@article{1e4e1993-555a-484a-be41-39b4ea66fc55,
  abstract     = {Gram-negative bacteria have the ability to produce outer membrane-derived vesicles (OMVs) that are released into the extracellular milieu. Even though this intriguing phenomenon is well-known since many years, various aspects of bacterial OMVs are not fully described and are still in the process of being characterized in detail. One major reason for this is that depending on the bacterial species and its respective ecological niche, OMVs exhibit an enormous functional diversity. Research of the past years has clearly shown that OMVs of many pathogenic bacteria contribute to the virulence potential by enriching virulence factors and delivering them over long distances, superseding direct bacterial contact with their host. The subsequent interaction of OMVs with the host can occur at different levels regarding the type of immune response or the target cell type and may lead to different outcomes ranging from non-immunogenic activation or a pro-inflammatory response to cytotoxicity. In contrast to being virulence factors, OMVs are used for vaccination purposes in the combat against bacterial pathogens, and recent research thus is focused on to indirectly aim these versatile bacterial weapons against themselves.},
  author       = {Ünal, Can and Schaar, Viveka and Riesbeck, Kristian},
  issn         = {1863-2300},
  language     = {eng},
  pages        = {395--408},
  publisher    = {Springer},
  series       = {Seminars in Immunopathology},
  title        = {Bacterial outer membrane vesicles in disease and preventive medicine.},
  url          = {http://dx.doi.org/10.1007/s00281-010-0231-y},
  volume       = {33},
  year         = {2011},
}