Advanced

Injury-induced activation of ERK 1/2 in the sciatic nerve of healthy and diabetic rats.

Stenberg, Lena LU ; Kanje, Martin; Mårtensson, Lisa and Dahlin, Lars LU (2011) In NeuroReport 22. p.73-77
Abstract
Phosphorylation of extracellular-signal-regulated kinase 1/2 (p-ERK 1/2) was investigated by immunohistochemistry at 30 min, 1 h, and 48 h after nerve transection in the sciatic nerve of healthy and diabetic [streptozotocin (STZ)-induced diabetes mellitus and BioBreeding (BB; i.e. DR.lyp/lyp or BBDP)] rats. Transection injury increased the intensity of p-ERK 1/2 in nerve stumps at all time points. Staining was confined to Schwann cells with occasional faint staining in single axons. In diabetic rats, a lower intensity of p-ERK 1/2 was found at 1 and 48 h in the distal and proximal nerve stumps compared with healthy rats. STZ-induced diabetic rats were not different from BB rats. p-ERK 1/2 is activated differentially in Schwann cells after... (More)
Phosphorylation of extracellular-signal-regulated kinase 1/2 (p-ERK 1/2) was investigated by immunohistochemistry at 30 min, 1 h, and 48 h after nerve transection in the sciatic nerve of healthy and diabetic [streptozotocin (STZ)-induced diabetes mellitus and BioBreeding (BB; i.e. DR.lyp/lyp or BBDP)] rats. Transection injury increased the intensity of p-ERK 1/2 in nerve stumps at all time points. Staining was confined to Schwann cells with occasional faint staining in single axons. In diabetic rats, a lower intensity of p-ERK 1/2 was found at 1 and 48 h in the distal and proximal nerve stumps compared with healthy rats. STZ-induced diabetic rats were not different from BB rats. p-ERK 1/2 is activated differentially in Schwann cells after nerve injury in diabetic rats, whereas activation in STZ-induced diabetic rats did not differ from BB rats. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
NeuroReport
volume
22
pages
73 - 77
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000285708300005
  • pmid:21150475
  • scopus:79551527646
ISSN
1473-558X
DOI
10.1097/WNR.0b013e328342986c
language
English
LU publication?
yes
id
f0c9ff83-2379-4a2b-ae15-09d6682ddc0b (old id 1756493)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21150475?dopt=Abstract
date added to LUP
2011-01-03 15:16:01
date last changed
2017-08-27 05:41:34
@article{f0c9ff83-2379-4a2b-ae15-09d6682ddc0b,
  abstract     = {Phosphorylation of extracellular-signal-regulated kinase 1/2 (p-ERK 1/2) was investigated by immunohistochemistry at 30 min, 1 h, and 48 h after nerve transection in the sciatic nerve of healthy and diabetic [streptozotocin (STZ)-induced diabetes mellitus and BioBreeding (BB; i.e. DR.lyp/lyp or BBDP)] rats. Transection injury increased the intensity of p-ERK 1/2 in nerve stumps at all time points. Staining was confined to Schwann cells with occasional faint staining in single axons. In diabetic rats, a lower intensity of p-ERK 1/2 was found at 1 and 48 h in the distal and proximal nerve stumps compared with healthy rats. STZ-induced diabetic rats were not different from BB rats. p-ERK 1/2 is activated differentially in Schwann cells after nerve injury in diabetic rats, whereas activation in STZ-induced diabetic rats did not differ from BB rats.},
  author       = {Stenberg, Lena and Kanje, Martin and Mårtensson, Lisa and Dahlin, Lars},
  issn         = {1473-558X},
  language     = {eng},
  pages        = {73--77},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {NeuroReport},
  title        = {Injury-induced activation of ERK 1/2 in the sciatic nerve of healthy and diabetic rats.},
  url          = {http://dx.doi.org/10.1097/WNR.0b013e328342986c},
  volume       = {22},
  year         = {2011},
}