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Vasomotor menopausal symptoms are associated with increased risk of coronary heart disease.

Gast, Gerrie-Cor M; Pop, Victor J M; Samsioe, Göran LU ; Grobbee, Diederick E; Nilsson, Peter M; Keyzer, Jules J; Wijnands-van Gent, Colette J M and van der Schouw, Yvonne T (2011) In Menopause 18. p.146-151
Abstract
OBJECTIVE:: Emerging evidence suggests that women with vasomotor menopausal symptoms (VMS) may have an adverse cardiovascular disease (CVD) risk profile. We investigated whether VMS are related to an increased risk of future coronary heart disease (CHD) and whether possible associations can be explained by CVD risk factors. METHODS:: Data used were from a Dutch and Swedish population-based sample of 10,787 women enrolled between 1995 and 2000, aged 46 to 64 years, and free of CVD at baseline. Data on VMS were collected by questionnaires. Body mass index and blood pressure were measured in all women, and total cholesterol levels were measured in a subgroup of the population. Multivariable Cox regression models were used to analyze the data.... (More)
OBJECTIVE:: Emerging evidence suggests that women with vasomotor menopausal symptoms (VMS) may have an adverse cardiovascular disease (CVD) risk profile. We investigated whether VMS are related to an increased risk of future coronary heart disease (CHD) and whether possible associations can be explained by CVD risk factors. METHODS:: Data used were from a Dutch and Swedish population-based sample of 10,787 women enrolled between 1995 and 2000, aged 46 to 64 years, and free of CVD at baseline. Data on VMS were collected by questionnaires. Body mass index and blood pressure were measured in all women, and total cholesterol levels were measured in a subgroup of the population. Multivariable Cox regression models were used to analyze the data. RESULTS:: After a mean ± SD follow-up period of 10.3 ± 2.1 years, 303 women were diagnosed with CHD. Symptoms of flushing were not associated with risk of CHD. However, the presence of night sweats was associated with a significantly modest increased risk of CHD, with a multivariable-adjusted hazard ratio of 1.33 (95% CI, 1.05-1.69). This association was attenuated but not eliminated after correction for body mass index, blood pressure, and total cholesterol (hazard ratio, 1.25; 95% CI, 0.99-1.58). CONCLUSIONS:: Women with menopausal symptoms of night sweats have a significantly moderately increased risk of CHD, which cannot be totally explained by the levels of CVD risk factors. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Menopause
volume
18
pages
146 - 151
publisher
Lippincott-Raven Publishers
external identifiers
  • wos:000286623500009
  • pmid:21127438
  • scopus:79951575715
ISSN
1530-0374
DOI
10.1097/gme.0b013e3181f464fb
language
English
LU publication?
yes
id
25e2deda-bc85-48a8-b98b-a5c8abeb89e4 (old id 1756771)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21127438?dopt=Abstract
date added to LUP
2011-01-03 12:23:17
date last changed
2017-11-19 04:17:12
@article{25e2deda-bc85-48a8-b98b-a5c8abeb89e4,
  abstract     = {OBJECTIVE:: Emerging evidence suggests that women with vasomotor menopausal symptoms (VMS) may have an adverse cardiovascular disease (CVD) risk profile. We investigated whether VMS are related to an increased risk of future coronary heart disease (CHD) and whether possible associations can be explained by CVD risk factors. METHODS:: Data used were from a Dutch and Swedish population-based sample of 10,787 women enrolled between 1995 and 2000, aged 46 to 64 years, and free of CVD at baseline. Data on VMS were collected by questionnaires. Body mass index and blood pressure were measured in all women, and total cholesterol levels were measured in a subgroup of the population. Multivariable Cox regression models were used to analyze the data. RESULTS:: After a mean ± SD follow-up period of 10.3 ± 2.1 years, 303 women were diagnosed with CHD. Symptoms of flushing were not associated with risk of CHD. However, the presence of night sweats was associated with a significantly modest increased risk of CHD, with a multivariable-adjusted hazard ratio of 1.33 (95% CI, 1.05-1.69). This association was attenuated but not eliminated after correction for body mass index, blood pressure, and total cholesterol (hazard ratio, 1.25; 95% CI, 0.99-1.58). CONCLUSIONS:: Women with menopausal symptoms of night sweats have a significantly moderately increased risk of CHD, which cannot be totally explained by the levels of CVD risk factors.},
  author       = {Gast, Gerrie-Cor M and Pop, Victor J M and Samsioe, Göran and Grobbee, Diederick E and Nilsson, Peter M and Keyzer, Jules J and Wijnands-van Gent, Colette J M and van der Schouw, Yvonne T},
  issn         = {1530-0374},
  language     = {eng},
  pages        = {146--151},
  publisher    = {Lippincott-Raven Publishers},
  series       = {Menopause},
  title        = {Vasomotor menopausal symptoms are associated with increased risk of coronary heart disease.},
  url          = {http://dx.doi.org/10.1097/gme.0b013e3181f464fb},
  volume       = {18},
  year         = {2011},
}