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The role of the cartilage matrix in osteoarthritis.

Heinegård, Dick LU and Saxne, Tore LU (2011) In Nature Reviews Rheumatology 7. p.50-56
Abstract
Osteoarthritis (OA) involves all the structures of the joint. How the disease is initiated and what factors trigger the disease process remain unclear, although the mechanical environment seems to have a role. Our understanding of the biology of the disease has been hampered by the lack of access to tissue samples from patients with early stage disease, because clinically recognizable symptoms appear late in the osteoarthritic process. However, new data about the early processes in articular cartilage and new tools to identify the early stages of OA are providing fresh insights into the pathological sequence of events. The progressive destruction of cartilage involves degradation of matrix constituents, and rather active, yet inefficient,... (More)
Osteoarthritis (OA) involves all the structures of the joint. How the disease is initiated and what factors trigger the disease process remain unclear, although the mechanical environment seems to have a role. Our understanding of the biology of the disease has been hampered by the lack of access to tissue samples from patients with early stage disease, because clinically recognizable symptoms appear late in the osteoarthritic process. However, new data about the early processes in articular cartilage and new tools to identify the early stages of OA are providing fresh insights into the pathological sequence of events. The progressive destruction of cartilage involves degradation of matrix constituents, and rather active, yet inefficient, repair attempts. The release of fragmented molecules provides opportunities to monitor the disease process in patients, and to investigate whether these fragments are involved in propagating OA, for example, by inducing inflammation. The role of bone has not been fully elucidated, but changes in bone seem to be secondary to alterations in articular cartilage, which change the mechanical environment of the bone cells and induce them, in turn, to modulate tissue structure. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Reviews Rheumatology
volume
7
pages
50 - 56
publisher
Nature Publishing Group
external identifiers
  • wos:000285920800009
  • pmid:21119607
  • scopus:78650982530
ISSN
1759-4804
DOI
10.1038/nrrheum.2010.198
language
English
LU publication?
yes
id
a8eb4273-2f6c-4ee8-bdf5-b38387942163 (old id 1756894)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21119607?dopt=Abstract
date added to LUP
2011-01-03 11:54:13
date last changed
2017-11-12 04:06:05
@article{a8eb4273-2f6c-4ee8-bdf5-b38387942163,
  abstract     = {Osteoarthritis (OA) involves all the structures of the joint. How the disease is initiated and what factors trigger the disease process remain unclear, although the mechanical environment seems to have a role. Our understanding of the biology of the disease has been hampered by the lack of access to tissue samples from patients with early stage disease, because clinically recognizable symptoms appear late in the osteoarthritic process. However, new data about the early processes in articular cartilage and new tools to identify the early stages of OA are providing fresh insights into the pathological sequence of events. The progressive destruction of cartilage involves degradation of matrix constituents, and rather active, yet inefficient, repair attempts. The release of fragmented molecules provides opportunities to monitor the disease process in patients, and to investigate whether these fragments are involved in propagating OA, for example, by inducing inflammation. The role of bone has not been fully elucidated, but changes in bone seem to be secondary to alterations in articular cartilage, which change the mechanical environment of the bone cells and induce them, in turn, to modulate tissue structure.},
  author       = {Heinegård, Dick and Saxne, Tore},
  issn         = {1759-4804},
  language     = {eng},
  pages        = {50--56},
  publisher    = {Nature Publishing Group},
  series       = {Nature Reviews Rheumatology},
  title        = {The role of the cartilage matrix in osteoarthritis.},
  url          = {http://dx.doi.org/10.1038/nrrheum.2010.198},
  volume       = {7},
  year         = {2011},
}