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The human periodontal ligament cell: a fibroblast-like cell acting as an immune cell.

Jönsson, Daniel LU ; Nebel, Daniel LU ; Bratthall, G and Nilsson, Bengt-Olof LU (2011) In Journal of Periodontal Research 46. p.153-157
Abstract
Jönsson D, Nebel D, Bratthall G, Nilsson B-O. The human periodontal ligament cell: a fibroblast-like cell acting as an immune cell. J Periodont Res 2010; doi: 10.1111/j.1600-0765.2010.01331.x. © 2010 John Wiley & Sons A/S Background: Periodontal ligament cells are fibroblast-like cells characterized by collagen production but also possessing some osteoblastic features. In the light of numerous studies presented during recent times, which show that human periodontal ligament cells also produce cytokines and chemokines in response to inflammation promoters, it is reasonable to suggest that periodontal ligament cells play a role as promoters of periodontal inflammation through these mechanisms. Material and Methods: The periodontal... (More)
Jönsson D, Nebel D, Bratthall G, Nilsson B-O. The human periodontal ligament cell: a fibroblast-like cell acting as an immune cell. J Periodont Res 2010; doi: 10.1111/j.1600-0765.2010.01331.x. © 2010 John Wiley & Sons A/S Background: Periodontal ligament cells are fibroblast-like cells characterized by collagen production but also possessing some osteoblastic features. In the light of numerous studies presented during recent times, which show that human periodontal ligament cells also produce cytokines and chemokines in response to inflammation promoters, it is reasonable to suggest that periodontal ligament cells play a role as promoters of periodontal inflammation through these mechanisms. Material and Methods: The periodontal ligament, which harbours the periodontal ligament cells, is a part of the attachment apparatus comprised of periodontal ligament cells, extracellular matrix and fibres, attaching the root cement to the alveolar bone. Periodontal ligament cells are in close proximity to bacteria within the plaque and the pocket, and thus these cells are readily accessible to bacterial endotoxins and other promoters of inflammation. Results: Cytokines and chemokines, released by periodontal ligament cells upon stimulation with inflammation promoters, reach the blood vessels easily thanks to rich vascularization of the periodontium stimulating recruitment of white blood cells to the site of inflammation. In addition to classical inflammatory cells, such as leucocytes, macrophages and mast cells, the periodontal ligament cells also contribute to periodontal inflammation via their production and release of cytokines and chemokines. Conclusion: Therefore, pharmacological treatment of periodontitis should aim to reduce the release of proinflammatory agents not only from classical inflammatory cells but also from periodontal ligament cells. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Periodontal Research
volume
46
pages
153 - 157
publisher
Wiley-Blackwell
external identifiers
  • wos:000287702700001
  • pmid:21118418
  • scopus:79951939678
ISSN
1600-0765
DOI
10.1111/j.1600-0765.2010.01331.x
language
English
LU publication?
yes
id
82ee9626-f146-4af7-acad-72a74b4ca1c0 (old id 1756928)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21118418?dopt=Abstract
date added to LUP
2011-01-03 11:37:31
date last changed
2017-11-19 04:17:51
@article{82ee9626-f146-4af7-acad-72a74b4ca1c0,
  abstract     = {Jönsson D, Nebel D, Bratthall G, Nilsson B-O. The human periodontal ligament cell: a fibroblast-like cell acting as an immune cell. J Periodont Res 2010; doi: 10.1111/j.1600-0765.2010.01331.x. © 2010 John Wiley & Sons A/S Background: Periodontal ligament cells are fibroblast-like cells characterized by collagen production but also possessing some osteoblastic features. In the light of numerous studies presented during recent times, which show that human periodontal ligament cells also produce cytokines and chemokines in response to inflammation promoters, it is reasonable to suggest that periodontal ligament cells play a role as promoters of periodontal inflammation through these mechanisms. Material and Methods: The periodontal ligament, which harbours the periodontal ligament cells, is a part of the attachment apparatus comprised of periodontal ligament cells, extracellular matrix and fibres, attaching the root cement to the alveolar bone. Periodontal ligament cells are in close proximity to bacteria within the plaque and the pocket, and thus these cells are readily accessible to bacterial endotoxins and other promoters of inflammation. Results: Cytokines and chemokines, released by periodontal ligament cells upon stimulation with inflammation promoters, reach the blood vessels easily thanks to rich vascularization of the periodontium stimulating recruitment of white blood cells to the site of inflammation. In addition to classical inflammatory cells, such as leucocytes, macrophages and mast cells, the periodontal ligament cells also contribute to periodontal inflammation via their production and release of cytokines and chemokines. Conclusion: Therefore, pharmacological treatment of periodontitis should aim to reduce the release of proinflammatory agents not only from classical inflammatory cells but also from periodontal ligament cells.},
  author       = {Jönsson, Daniel and Nebel, Daniel and Bratthall, G and Nilsson, Bengt-Olof},
  issn         = {1600-0765},
  language     = {eng},
  pages        = {153--157},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of Periodontal Research},
  title        = {The human periodontal ligament cell: a fibroblast-like cell acting as an immune cell.},
  url          = {http://dx.doi.org/10.1111/j.1600-0765.2010.01331.x},
  volume       = {46},
  year         = {2011},
}