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Age-specific familial risks of depression : a nation-wide epidemiological study from Sweden

Li, Xinjun LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2008) In Journal of Psychiatric Research 42(10). p.14-808
Abstract

OBJECTIVE: Familial risks of depression have been assessed in small case-control studies, usually based on reported, but not medically verified, depressions in family members; thus the degree of familial clustering of these diseases remains to be established.

METHODS: The Multigeneration Register, in which all men and women born in Sweden from 1932 onward are registered together with their parents, was linked to hospital admission data. Standardized incidence ratios (SIRs) were calculated as the ratio of the observed to the expected number of cases in men and women with mothers or fathers affected by depression, compared with men and women whose mothers or fathers were not affected by depression.

RESULTS: A total of... (More)

OBJECTIVE: Familial risks of depression have been assessed in small case-control studies, usually based on reported, but not medically verified, depressions in family members; thus the degree of familial clustering of these diseases remains to be established.

METHODS: The Multigeneration Register, in which all men and women born in Sweden from 1932 onward are registered together with their parents, was linked to hospital admission data. Standardized incidence ratios (SIRs) were calculated as the ratio of the observed to the expected number of cases in men and women with mothers or fathers affected by depression, compared with men and women whose mothers or fathers were not affected by depression.

RESULTS: A total of respectively 60,477 and 79,969 depressions were recorded in offspring and parents. In 6.44% of all families, an offspring and a parent were affected, giving a population-attributable proportion of 4.04% and a familial SIR of 2.68. The parental transmission of depression was similar for both men and women (2.72 and 2.66).

CONCLUSIONS: This study has provided the first data on age-specific familial clustering of depressions, based on medically confirmed records. The risks were so high that hereditary factors were considered to be likely to contribute to depression, possibly modified by environmental factors. Age-specific risk tables would be helpful for clinical counseling.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adolescent, Adult, Age Factors, Aged, Depressive Disorder/epidemiology, Female, Genetic Predisposition to Disease/epidemiology, Health Surveys, Humans, Male, Middle Aged, Risk, Sweden
in
Journal of Psychiatric Research
volume
42
issue
10
pages
7 pages
publisher
Elsevier
external identifiers
  • scopus:44649149499
ISSN
0022-3956
DOI
10.1016/j.jpsychires.2007.09.003
language
English
LU publication?
no
id
176ad4c0-b5af-4571-9857-43d35b990250
date added to LUP
2019-01-30 11:04:31
date last changed
2019-02-20 11:45:42
@article{176ad4c0-b5af-4571-9857-43d35b990250,
  abstract     = {<p>OBJECTIVE: Familial risks of depression have been assessed in small case-control studies, usually based on reported, but not medically verified, depressions in family members; thus the degree of familial clustering of these diseases remains to be established.</p><p>METHODS: The Multigeneration Register, in which all men and women born in Sweden from 1932 onward are registered together with their parents, was linked to hospital admission data. Standardized incidence ratios (SIRs) were calculated as the ratio of the observed to the expected number of cases in men and women with mothers or fathers affected by depression, compared with men and women whose mothers or fathers were not affected by depression.</p><p>RESULTS: A total of respectively 60,477 and 79,969 depressions were recorded in offspring and parents. In 6.44% of all families, an offspring and a parent were affected, giving a population-attributable proportion of 4.04% and a familial SIR of 2.68. The parental transmission of depression was similar for both men and women (2.72 and 2.66).</p><p>CONCLUSIONS: This study has provided the first data on age-specific familial clustering of depressions, based on medically confirmed records. The risks were so high that hereditary factors were considered to be likely to contribute to depression, possibly modified by environmental factors. Age-specific risk tables would be helpful for clinical counseling.</p>},
  author       = {Li, Xinjun and Sundquist, Jan and Sundquist, Kristina},
  issn         = {0022-3956},
  keyword      = {Adolescent,Adult,Age Factors,Aged,Depressive Disorder/epidemiology,Female,Genetic Predisposition to Disease/epidemiology,Health Surveys,Humans,Male,Middle Aged,Risk,Sweden},
  language     = {eng},
  number       = {10},
  pages        = {14--808},
  publisher    = {Elsevier},
  series       = {Journal of Psychiatric Research},
  title        = {Age-specific familial risks of depression : a nation-wide epidemiological study from Sweden},
  url          = {http://dx.doi.org/10.1016/j.jpsychires.2007.09.003},
  volume       = {42},
  year         = {2008},
}