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Menstrual and Reproductive Factors, Exogenous Hormone Use, and Gastric Cancer Risk in a Cohort of Women From the European Prospective Investigation Into Cancer and Nutrition

Duell, Eric J.; Travier, Noemie; Lujan-Barroso, Leila; Boutron-Ruault, M. C.; Clavel-Chapelon, F.; Palli, Domenico; Krogh, Vittorio; Mattiello, Amalia; Tumino, Rosario and Sacerdote, Carlotta, et al. (2010) In American Journal of Epidemiology 172(12). p.1384-1393
Abstract
The worldwide incidence of gastric adenocarcinoma (GC) is lower in women than in men. Furthermore, cancer patients treated with estrogens have been reported to have a lower subsequent risk of GC. The authors conducted a prospective analysis of menstrual and reproductive factors, exogenous hormone use, and GC in 335,216 women from the European Prospective Investigation Into Cancer and Nutrition, a cohort study of individuals aged 35-70 years from 10 European countries. After a mean follow-up of 8.7 years (through 2004), 181 women for whom complete exposure data were available developed GC. Adjusted hazard ratios and 95% confidence intervals were estimated using Cox proportional hazards models. All statistical tests were 2-sided. Women who... (More)
The worldwide incidence of gastric adenocarcinoma (GC) is lower in women than in men. Furthermore, cancer patients treated with estrogens have been reported to have a lower subsequent risk of GC. The authors conducted a prospective analysis of menstrual and reproductive factors, exogenous hormone use, and GC in 335,216 women from the European Prospective Investigation Into Cancer and Nutrition, a cohort study of individuals aged 35-70 years from 10 European countries. After a mean follow-up of 8.7 years (through 2004), 181 women for whom complete exposure data were available developed GC. Adjusted hazard ratios and 95% confidence intervals were estimated using Cox proportional hazards models. All statistical tests were 2-sided. Women who had ovariectomy had a 79% increased risk of GC (based on 25 cases) compared with women who did not (hazard ratio = 1.79, 95% confidence interval: 1.15, 2.78). Total cumulative years of menstrual cycling was inversely associated with GC risk (fifth vs. first quintile: hazard ratio = 0.55, 95% confidence interval: 0.31, 0.98; P-trend = 0.06). No other reproductive factors analyzed were associated with risk of GC. The results of this analysis provide some support for the hypothesis that endogenous ovarian sex hormones lower GC incidence in women. (Less)
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published
subject
keywords
stomach neoplasms, reproduction, menstruation, estrogens, hormones, women
in
American Journal of Epidemiology
volume
172
issue
12
pages
1384 - 1393
publisher
Oxford University Press
external identifiers
  • wos:000285193200009
  • scopus:79952117656
ISSN
0002-9262
DOI
10.1093/aje/kwq321
language
English
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yes
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4a074f48-1455-4ec0-bfd1-331335f19bc4 (old id 1773562)
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2011-02-01 15:38:14
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2018-05-29 12:05:58
@article{4a074f48-1455-4ec0-bfd1-331335f19bc4,
  abstract     = {The worldwide incidence of gastric adenocarcinoma (GC) is lower in women than in men. Furthermore, cancer patients treated with estrogens have been reported to have a lower subsequent risk of GC. The authors conducted a prospective analysis of menstrual and reproductive factors, exogenous hormone use, and GC in 335,216 women from the European Prospective Investigation Into Cancer and Nutrition, a cohort study of individuals aged 35-70 years from 10 European countries. After a mean follow-up of 8.7 years (through 2004), 181 women for whom complete exposure data were available developed GC. Adjusted hazard ratios and 95% confidence intervals were estimated using Cox proportional hazards models. All statistical tests were 2-sided. Women who had ovariectomy had a 79% increased risk of GC (based on 25 cases) compared with women who did not (hazard ratio = 1.79, 95% confidence interval: 1.15, 2.78). Total cumulative years of menstrual cycling was inversely associated with GC risk (fifth vs. first quintile: hazard ratio = 0.55, 95% confidence interval: 0.31, 0.98; P-trend = 0.06). No other reproductive factors analyzed were associated with risk of GC. The results of this analysis provide some support for the hypothesis that endogenous ovarian sex hormones lower GC incidence in women.},
  author       = {Duell, Eric J. and Travier, Noemie and Lujan-Barroso, Leila and Boutron-Ruault, M. C. and Clavel-Chapelon, F. and Palli, Domenico and Krogh, Vittorio and Mattiello, Amalia and Tumino, Rosario and Sacerdote, Carlotta and Rodriguez, Laudina and Sanchez-Cantalejo, Emilio and Navarro, Carmen and Barricarte, Aurelio and Dorronsoro, Miren and Khaw, Kay-Tee and Wareham, Nicholas and Allen, Naomi E. and Tsilidis, Konstantinos K. and Bueno-de-Mesquita, H. Bas and Jeurnink, Suzanne M. and Numans, M. E. and Peeters, Petra H. M. and Lagiou, Pagona and Valanou, Elisabeth and Trichopoulou, Antonia and Kaaks, Rudolf and Lukanova-McGregor, Annekatrin and Bergman, Manuela M. and Boeing, Heiner and Manjer, Jonas and Lindkvist, Bjorn and Stenling, Roger and Hallmans, Goran and Dahm, Christina C. and Overvad, Kim and Olsen, Anja and Tjonneland, Anne and Bakken, Kjersti and Lund, Eiliv and Jenab, Mazda and McCormack, Valerie and Rinaldi, Sabina and Michaud, Dominique and Mouw, Traci and Nesi, Gabriella and Carneiro, Fatima and Riboli, Elio and Gonzalez, Carlos A.},
  issn         = {0002-9262},
  keyword      = {stomach neoplasms,reproduction,menstruation,estrogens,hormones,women},
  language     = {eng},
  number       = {12},
  pages        = {1384--1393},
  publisher    = {Oxford University Press},
  series       = {American Journal of Epidemiology},
  title        = {Menstrual and Reproductive Factors, Exogenous Hormone Use, and Gastric Cancer Risk in a Cohort of Women From the European Prospective Investigation Into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1093/aje/kwq321},
  volume       = {172},
  year         = {2010},
}