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Occupation and risk of lymphoma: a multicentre prospective cohort study (EPIC)

Neasham, David; Sifi, Ahlem; Nielsen, Kaspar Rene; Overvad, Kim; Raaschou-Nielsen, Ole; Tjonneland, Anne; Barricarte, Aurelio; Gonzalez, Carlos A.; Navarro, Carmen and Suarez, Laudina Rodriguez, et al. (2011) In Occupational and Environmental Medicine 68(1). p.77-81
Abstract
Objectives Evidence suggests that certain occupations and related exposures may increase the risk of malignant lymphoma. Farming, printing and paper industry, wood processing, meat handling and processing, welding, shoe and leather manufacturing and teaching profession are among the categories that have been implicated in previous studies. The relationship between occupation and malignant lymphoma has been investigated in a large European prospective study. Methods We investigated occupational risks for lymphomas in the European Prospective Investigation into Cancer and Nutrition (EPIC). The mean follow-up time for 348 555 subjects was 9 years (SD: 2 years). The analysis was based on 866 and 48 newly diagnosed cases of non-Hodgkin's... (More)
Objectives Evidence suggests that certain occupations and related exposures may increase the risk of malignant lymphoma. Farming, printing and paper industry, wood processing, meat handling and processing, welding, shoe and leather manufacturing and teaching profession are among the categories that have been implicated in previous studies. The relationship between occupation and malignant lymphoma has been investigated in a large European prospective study. Methods We investigated occupational risks for lymphomas in the European Prospective Investigation into Cancer and Nutrition (EPIC). The mean follow-up time for 348 555 subjects was 9 years (SD: 2 years). The analysis was based on 866 and 48 newly diagnosed cases of non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL). These were identified in the EPIC subcohorts with occupational data. Data on 52 occupations were collected through standardised questionnaires. Cox proportional hazard models were used to explore the association between occupation and risk of malignant lymphoma. Results The following occupations were positively associated with malignant NHL after adjustment for study centre, age, sex, socioeconomic status (SES), smoking and alcohol: butchers (HR=1.53, 95% CI 1.05 to 2.48, including multiple myeloma/plasmacytoma; HR=1.30, 95% CI 1.00 to 2.66, excluding multiple myeloma/plasmacytoma) and car repair workers (HR=1.50, 95% CI 1.01 to 2.00, including multiple myeloma/plasmacytoma; HR=1.51, 95% CI 1.01 to 2.31, excluding multiple myeloma/plasmacytoma). HL was associated with gasoline station occupation (HR=4.59, 95% CI 1.08 to 19.6). Conclusion The findings in this current study of a higher risk of NHL among car repair workers and butchers and a higher risk of HL among gasoline station workers suggest a possible role from occupationally related exposures, such as solvents and zoonotic viruses, as risk factors for malignant lymphoma. (Less)
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Occupational and Environmental Medicine
volume
68
issue
1
pages
77 - 81
publisher
BMJ Publishing Group
external identifiers
  • wos:000285182900014
  • scopus:78651396162
ISSN
1470-7926
DOI
10.1136/oem.2009.048173
language
English
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yes
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cfc571b3-f505-4ada-84ca-099f6244a8d4 (old id 1774114)
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2011-02-01 09:58:19
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2017-10-22 03:59:01
@article{cfc571b3-f505-4ada-84ca-099f6244a8d4,
  abstract     = {Objectives Evidence suggests that certain occupations and related exposures may increase the risk of malignant lymphoma. Farming, printing and paper industry, wood processing, meat handling and processing, welding, shoe and leather manufacturing and teaching profession are among the categories that have been implicated in previous studies. The relationship between occupation and malignant lymphoma has been investigated in a large European prospective study. Methods We investigated occupational risks for lymphomas in the European Prospective Investigation into Cancer and Nutrition (EPIC). The mean follow-up time for 348 555 subjects was 9 years (SD: 2 years). The analysis was based on 866 and 48 newly diagnosed cases of non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL). These were identified in the EPIC subcohorts with occupational data. Data on 52 occupations were collected through standardised questionnaires. Cox proportional hazard models were used to explore the association between occupation and risk of malignant lymphoma. Results The following occupations were positively associated with malignant NHL after adjustment for study centre, age, sex, socioeconomic status (SES), smoking and alcohol: butchers (HR=1.53, 95% CI 1.05 to 2.48, including multiple myeloma/plasmacytoma; HR=1.30, 95% CI 1.00 to 2.66, excluding multiple myeloma/plasmacytoma) and car repair workers (HR=1.50, 95% CI 1.01 to 2.00, including multiple myeloma/plasmacytoma; HR=1.51, 95% CI 1.01 to 2.31, excluding multiple myeloma/plasmacytoma). HL was associated with gasoline station occupation (HR=4.59, 95% CI 1.08 to 19.6). Conclusion The findings in this current study of a higher risk of NHL among car repair workers and butchers and a higher risk of HL among gasoline station workers suggest a possible role from occupationally related exposures, such as solvents and zoonotic viruses, as risk factors for malignant lymphoma.},
  author       = {Neasham, David and Sifi, Ahlem and Nielsen, Kaspar Rene and Overvad, Kim and Raaschou-Nielsen, Ole and Tjonneland, Anne and Barricarte, Aurelio and Gonzalez, Carlos A. and Navarro, Carmen and Suarez, Laudina Rodriguez and Travis, Ruth C. and Key, Tim and Linseisen, Jakob and Kaaks, Rudolf and Crosignani, Paolo and Berrino, Franco and Rosso, Stefano and Mattiello, Amalia and Vermeulen, R. C. H. and Bueno-de-Mesquita, H. Bas and Berglund, Göran and Manjer, Jonas and Zackrisson, Sophia and Hallmans, Goran and Malmer, Beatrice and Bingham, Sheila and Khaw, Kay Tee and Bergmann, Manuela M. and Boeing, Heiner and Trichopoulou, Antonia and Masala, Giovanna and Tumino, Rosario and Lund, Eiliv and Slimani, Nadia and Ferrari, Pietro and Boffetta, Paolo and Vineis, Paolo and Riboli, Elio},
  issn         = {1470-7926},
  language     = {eng},
  number       = {1},
  pages        = {77--81},
  publisher    = {BMJ Publishing Group},
  series       = {Occupational and Environmental Medicine},
  title        = {Occupation and risk of lymphoma: a multicentre prospective cohort study (EPIC)},
  url          = {http://dx.doi.org/10.1136/oem.2009.048173},
  volume       = {68},
  year         = {2011},
}