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A factor analytic approach to symptom patterns in dementia.

Gustafson, Lars LU ; Erikson, Catarina LU ; Warkentin, Siegbert LU ; Brun, Arne LU ; Englund, Elisabet LU and Passant, Ulla LU (2010) In International Journal of Alzheimer's Disease
Abstract
Previous publications have shown a high diagnostic sensitivity and specificity of three short clinical rating scales for Alzheimer's disease (AD), frontotemporal dementia (FTD), and vascular dementia (VaD) validated against neuropathological (NP) diagnoses. In this study, the aim was to perform an exploratory factor analysis of the items in these clinical rating scales. The study included 190 patients with postmortem diagnoses of AD (n = 74), VaD (n = 33), mixed AD/VaD (n = 31), or FTD (n = 52). The factor analysis produced three strong factors. Factor 1 contained items describing cerebrovascular disease, similar to the Hachinski Ischemic Score. Factor 2 enclosed major clinical characteristics of FTD, and factor 3 showed a striking... (More)
Previous publications have shown a high diagnostic sensitivity and specificity of three short clinical rating scales for Alzheimer's disease (AD), frontotemporal dementia (FTD), and vascular dementia (VaD) validated against neuropathological (NP) diagnoses. In this study, the aim was to perform an exploratory factor analysis of the items in these clinical rating scales. The study included 190 patients with postmortem diagnoses of AD (n = 74), VaD (n = 33), mixed AD/VaD (n = 31), or FTD (n = 52). The factor analysis produced three strong factors. Factor 1 contained items describing cerebrovascular disease, similar to the Hachinski Ischemic Score. Factor 2 enclosed major clinical characteristics of FTD, and factor 3 showed a striking similarity to the AD scale. A fourth symptom cluster was described by perception and expression of emotions. The factor analyses strongly support the construct validity of the diagnostic rating scales. (Less)
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author
organization
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type
Contribution to journal
publication status
published
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in
International Journal of Alzheimer's Disease
publisher
Hindawi Publishing Corporation
external identifiers
  • pmid:21253531
  • scopus:79952127115
ISSN
2090-0252
DOI
10.4061/2011/632604
language
English
LU publication?
yes
id
43d4e72d-b03f-4ad8-be1d-fd45a3881341 (old id 1777169)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21253531?dopt=Abstract
date added to LUP
2011-02-01 13:58:11
date last changed
2018-06-24 04:45:38
@article{43d4e72d-b03f-4ad8-be1d-fd45a3881341,
  abstract     = {Previous publications have shown a high diagnostic sensitivity and specificity of three short clinical rating scales for Alzheimer's disease (AD), frontotemporal dementia (FTD), and vascular dementia (VaD) validated against neuropathological (NP) diagnoses. In this study, the aim was to perform an exploratory factor analysis of the items in these clinical rating scales. The study included 190 patients with postmortem diagnoses of AD (n = 74), VaD (n = 33), mixed AD/VaD (n = 31), or FTD (n = 52). The factor analysis produced three strong factors. Factor 1 contained items describing cerebrovascular disease, similar to the Hachinski Ischemic Score. Factor 2 enclosed major clinical characteristics of FTD, and factor 3 showed a striking similarity to the AD scale. A fourth symptom cluster was described by perception and expression of emotions. The factor analyses strongly support the construct validity of the diagnostic rating scales.},
  author       = {Gustafson, Lars and Erikson, Catarina and Warkentin, Siegbert and Brun, Arne and Englund, Elisabet and Passant, Ulla},
  issn         = {2090-0252},
  language     = {eng},
  publisher    = {Hindawi Publishing Corporation},
  series       = {International Journal of Alzheimer's Disease},
  title        = {A factor analytic approach to symptom patterns in dementia.},
  url          = {http://dx.doi.org/10.4061/2011/632604},
  year         = {2010},
}