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Hyperfiltration evaluated by glomerular filtration rate at diagnosis in children with cancer.

Hjorth, Lars LU ; Wiebe, Thomas LU and Karpman, Diana LU (2011) In Pediatric Blood & Cancer 56(5). p.762-766
Abstract
BACKGROUND: Renal glomerular filtration rate (GFR) of pediatric cancer patients at diagnosis has previously been investigated in a limited number of studies. PROCEDURE: GFR, measured by iohexol clearance, was prospectively investigated in 55 children over the age of 1 year with malignancies, (group A). Elevated GFR (>175 ml/min/1.73 m(2)) at diagnosis was found. To investigate if this finding was consistent, a second group of 76 children with malignancies was studied, (group B). As a method control for GFR obtained by iohexol clearance, group A and B together were compared to 298 pediatric patients without cancer, group C. RESULTS: GFR was elevated in 40/131 (31%) in Group A + B but only in 17/298 (6%) in Group C. GFR was significantly... (More)
BACKGROUND: Renal glomerular filtration rate (GFR) of pediatric cancer patients at diagnosis has previously been investigated in a limited number of studies. PROCEDURE: GFR, measured by iohexol clearance, was prospectively investigated in 55 children over the age of 1 year with malignancies, (group A). Elevated GFR (>175 ml/min/1.73 m(2)) at diagnosis was found. To investigate if this finding was consistent, a second group of 76 children with malignancies was studied, (group B). As a method control for GFR obtained by iohexol clearance, group A and B together were compared to 298 pediatric patients without cancer, group C. RESULTS: GFR was elevated in 40/131 (31%) in Group A + B but only in 17/298 (6%) in Group C. GFR was significantly higher in children aged 1-5 in group A + B (47%) compared to group C (3%). Bone marrow involvement was significantly associated with higher GFR. Children without bone marrow involvement also hyperfiltrated more often than controls, but less often. Urea in urine was used as a marker of renal protein clearance in 14 patients in group A. A significant correlation between u-urea (mmol/L)/u-creatinine (mmol/L) and GFR was noted. CONCLUSIONS: Hyperfiltration is sometimes present in children with cancer at diagnosis. This may be related to increased amino acid turn over in patients with a large tumor burden. An elevated initial GFR in a child with cancer, which normalizes after chemotherapy may indicate chemotherapy-induced decreased renal function, but can be due to normalization of an initially high GFR. Pediatr Blood Cancer © 2011 Wiley-Liss, Inc. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pediatric Blood & Cancer
volume
56
issue
5
pages
762 - 766
publisher
John Wiley and Sons Inc.
external identifiers
  • wos:000288132100010
  • pmid:21241013
  • scopus:79952123933
ISSN
1545-5017
DOI
10.1002/pbc.22971
language
English
LU publication?
yes
id
e64668b1-2e7a-4447-88fa-ca680b704be8 (old id 1777416)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21241013?dopt=Abstract
date added to LUP
2011-02-01 14:19:17
date last changed
2017-05-21 04:34:44
@article{e64668b1-2e7a-4447-88fa-ca680b704be8,
  abstract     = {BACKGROUND: Renal glomerular filtration rate (GFR) of pediatric cancer patients at diagnosis has previously been investigated in a limited number of studies. PROCEDURE: GFR, measured by iohexol clearance, was prospectively investigated in 55 children over the age of 1 year with malignancies, (group A). Elevated GFR (>175 ml/min/1.73 m(2)) at diagnosis was found. To investigate if this finding was consistent, a second group of 76 children with malignancies was studied, (group B). As a method control for GFR obtained by iohexol clearance, group A and B together were compared to 298 pediatric patients without cancer, group C. RESULTS: GFR was elevated in 40/131 (31%) in Group A + B but only in 17/298 (6%) in Group C. GFR was significantly higher in children aged 1-5 in group A + B (47%) compared to group C (3%). Bone marrow involvement was significantly associated with higher GFR. Children without bone marrow involvement also hyperfiltrated more often than controls, but less often. Urea in urine was used as a marker of renal protein clearance in 14 patients in group A. A significant correlation between u-urea (mmol/L)/u-creatinine (mmol/L) and GFR was noted. CONCLUSIONS: Hyperfiltration is sometimes present in children with cancer at diagnosis. This may be related to increased amino acid turn over in patients with a large tumor burden. An elevated initial GFR in a child with cancer, which normalizes after chemotherapy may indicate chemotherapy-induced decreased renal function, but can be due to normalization of an initially high GFR. Pediatr Blood Cancer © 2011 Wiley-Liss, Inc.},
  author       = {Hjorth, Lars and Wiebe, Thomas and Karpman, Diana},
  issn         = {1545-5017},
  language     = {eng},
  number       = {5},
  pages        = {762--766},
  publisher    = {John Wiley and Sons Inc.},
  series       = {Pediatric Blood & Cancer},
  title        = {Hyperfiltration evaluated by glomerular filtration rate at diagnosis in children with cancer.},
  url          = {http://dx.doi.org/10.1002/pbc.22971},
  volume       = {56},
  year         = {2011},
}