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Gastric bypass surgery, but not caloric restriction, decreases dipeptidyl peptidase 4 activity in obese patients with type 2 diabetes.

Alam, M; Van der Schueren, B J; Ahrén, Bo LU ; Wang, G C; Swerdlow, N J; Arias, S; Bose, M; Gorroochurn, P; Teixeira, J and McGinty, J, et al. (2011) In Diabetes, Obesity and Metabolism 13(4). p.378-381
Abstract
The mechanism by which incretins and their effect on insulin secretion increase markedly following gastric bypass surgery (GBP) is not fully elucidated. We hypothesized that a decrease in the activity of dipeptidyl peptidase-4 (DPP-4), the enzyme which inactivates incretins, may explain the rise in incretin levels post-GBP. Fasting plasma DPP-4 activity was measured after 10 kg equivalent weight loss by GBP (n=16) or by caloric restriction (CR, n=14) in obese patients with type 2 diabetes. DPP-4 activity decreased after GBP by 11.6% (p=0.01), but not after CR. The increased peak GLP-1 and GIP response to oral glucose after GBP did not correlate with DPP-4 activity. The decrease in fasting plasma DPP-4 activity after GBP occurred by a... (More)
The mechanism by which incretins and their effect on insulin secretion increase markedly following gastric bypass surgery (GBP) is not fully elucidated. We hypothesized that a decrease in the activity of dipeptidyl peptidase-4 (DPP-4), the enzyme which inactivates incretins, may explain the rise in incretin levels post-GBP. Fasting plasma DPP-4 activity was measured after 10 kg equivalent weight loss by GBP (n=16) or by caloric restriction (CR, n=14) in obese patients with type 2 diabetes. DPP-4 activity decreased after GBP by 11.6% (p=0.01), but not after CR. The increased peak GLP-1 and GIP response to oral glucose after GBP did not correlate with DPP-4 activity. The decrease in fasting plasma DPP-4 activity after GBP occurred by a mechanism independent of weight loss and did not relate to change in incretins concentrations. Whether the change in DPP-4 activity contributes to improved diabetes control after GBP remains therefore to be determined. (Less)
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Contribution to journal
publication status
published
subject
keywords
dipeptidyl peptidase inhibitor, gastric bypass, weight loss, GLP-1
in
Diabetes, Obesity and Metabolism
volume
13
issue
4
pages
378 - 381
publisher
Wiley-Blackwell
external identifiers
  • wos:000287663500010
  • pmid:21210936
  • scopus:79951868952
ISSN
1462-8902
DOI
10.1111/j.1463-1326.2011.01358.x
language
English
LU publication?
yes
id
524c4190-f041-4ecc-ae88-a1eb9fedd4f5 (old id 1777738)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21210936?dopt=Abstract
date added to LUP
2011-02-01 11:09:23
date last changed
2017-08-06 03:02:12
@article{524c4190-f041-4ecc-ae88-a1eb9fedd4f5,
  abstract     = {The mechanism by which incretins and their effect on insulin secretion increase markedly following gastric bypass surgery (GBP) is not fully elucidated. We hypothesized that a decrease in the activity of dipeptidyl peptidase-4 (DPP-4), the enzyme which inactivates incretins, may explain the rise in incretin levels post-GBP. Fasting plasma DPP-4 activity was measured after 10 kg equivalent weight loss by GBP (n=16) or by caloric restriction (CR, n=14) in obese patients with type 2 diabetes. DPP-4 activity decreased after GBP by 11.6% (p=0.01), but not after CR. The increased peak GLP-1 and GIP response to oral glucose after GBP did not correlate with DPP-4 activity. The decrease in fasting plasma DPP-4 activity after GBP occurred by a mechanism independent of weight loss and did not relate to change in incretins concentrations. Whether the change in DPP-4 activity contributes to improved diabetes control after GBP remains therefore to be determined.},
  author       = {Alam, M and Van der Schueren, B J and Ahrén, Bo and Wang, G C and Swerdlow, N J and Arias, S and Bose, M and Gorroochurn, P and Teixeira, J and McGinty, J and Laferrère, B},
  issn         = {1462-8902},
  keyword      = {dipeptidyl peptidase inhibitor,gastric bypass,weight loss,GLP-1},
  language     = {eng},
  number       = {4},
  pages        = {378--381},
  publisher    = {Wiley-Blackwell},
  series       = {Diabetes, Obesity and Metabolism},
  title        = {Gastric bypass surgery, but not caloric restriction, decreases dipeptidyl peptidase 4 activity in obese patients with type 2 diabetes.},
  url          = {http://dx.doi.org/10.1111/j.1463-1326.2011.01358.x},
  volume       = {13},
  year         = {2011},
}