Ligand-induced tyrosine phosphorylation of cysteinyl leukotriene receptor 1 triggers internalization and signaling in intestinal epithelial cells.
(2010) In PLoS ONE 5(12).- Abstract
- Leukotriene D(4) (LTD(4)) belongs to the bioactive lipid group known as eicosanoids and has implications in pathological processes such as inflammation and cancer. Leukotriene D(4) exerts its effects mainly through two different G-protein-coupled receptors, CysLT(1) and CysLT(2). The high affinity LTD(4) receptor CysLT(1)R exhibits tumor-promoting properties by triggering cell proliferation, survival, and migration in intestinal epithelial cells. In addition, increased expression and nuclear localization of CysLT(1)R correlates with a poorer prognosis for patients with colon cancer.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1777847
- author
- Parhamifar, Ladan ; Sime, Wondossen LU ; Yudina, Yuliana ; Vilhardt, Frederik ; Mörgelin, Matthias LU and Sjölander, Anita LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 5
- issue
- 12
- article number
- e14439
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- wos:000285792500015
- pmid:21203429
- scopus:78650844218
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0014439
- language
- English
- LU publication?
- yes
- id
- 02d8ab3b-d5e8-419f-839f-4dab40b9b98e (old id 1777847)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21203429?dopt=Abstract
- date added to LUP
- 2016-04-04 09:11:59
- date last changed
- 2022-02-28 06:48:23
@article{02d8ab3b-d5e8-419f-839f-4dab40b9b98e, abstract = {{Leukotriene D(4) (LTD(4)) belongs to the bioactive lipid group known as eicosanoids and has implications in pathological processes such as inflammation and cancer. Leukotriene D(4) exerts its effects mainly through two different G-protein-coupled receptors, CysLT(1) and CysLT(2). The high affinity LTD(4) receptor CysLT(1)R exhibits tumor-promoting properties by triggering cell proliferation, survival, and migration in intestinal epithelial cells. In addition, increased expression and nuclear localization of CysLT(1)R correlates with a poorer prognosis for patients with colon cancer.}}, author = {{Parhamifar, Ladan and Sime, Wondossen and Yudina, Yuliana and Vilhardt, Frederik and Mörgelin, Matthias and Sjölander, Anita}}, issn = {{1932-6203}}, language = {{eng}}, number = {{12}}, publisher = {{Public Library of Science (PLoS)}}, series = {{PLoS ONE}}, title = {{Ligand-induced tyrosine phosphorylation of cysteinyl leukotriene receptor 1 triggers internalization and signaling in intestinal epithelial cells.}}, url = {{https://lup.lub.lu.se/search/files/5258749/1787792.pdf}}, doi = {{10.1371/journal.pone.0014439}}, volume = {{5}}, year = {{2010}}, }