Advanced

Ligand-induced tyrosine phosphorylation of cysteinyl leukotriene receptor 1 triggers internalization and signaling in intestinal epithelial cells.

Parhamifar, Ladan; Sime, Wondossen LU ; Yudina, Yuliana; Vilhardt, Frederik; Mörgelin, Matthias LU and Sjölander, Anita LU (2010) In PLoS ONE 5(12).
Abstract
Leukotriene D(4) (LTD(4)) belongs to the bioactive lipid group known as eicosanoids and has implications in pathological processes such as inflammation and cancer. Leukotriene D(4) exerts its effects mainly through two different G-protein-coupled receptors, CysLT(1) and CysLT(2). The high affinity LTD(4) receptor CysLT(1)R exhibits tumor-promoting properties by triggering cell proliferation, survival, and migration in intestinal epithelial cells. In addition, increased expression and nuclear localization of CysLT(1)R correlates with a poorer prognosis for patients with colon cancer.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
5
issue
12
publisher
Public Library of Science
external identifiers
  • wos:000285792500015
  • pmid:21203429
  • scopus:78650844218
ISSN
1932-6203
DOI
10.1371/journal.pone.0014439
language
English
LU publication?
yes
id
02d8ab3b-d5e8-419f-839f-4dab40b9b98e (old id 1777847)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21203429?dopt=Abstract
date added to LUP
2011-02-01 10:25:16
date last changed
2017-06-18 04:42:33
@article{02d8ab3b-d5e8-419f-839f-4dab40b9b98e,
  abstract     = {Leukotriene D(4) (LTD(4)) belongs to the bioactive lipid group known as eicosanoids and has implications in pathological processes such as inflammation and cancer. Leukotriene D(4) exerts its effects mainly through two different G-protein-coupled receptors, CysLT(1) and CysLT(2). The high affinity LTD(4) receptor CysLT(1)R exhibits tumor-promoting properties by triggering cell proliferation, survival, and migration in intestinal epithelial cells. In addition, increased expression and nuclear localization of CysLT(1)R correlates with a poorer prognosis for patients with colon cancer.},
  articleno    = {e14439},
  author       = {Parhamifar, Ladan and Sime, Wondossen and Yudina, Yuliana and Vilhardt, Frederik and Mörgelin, Matthias and Sjölander, Anita},
  issn         = {1932-6203},
  language     = {eng},
  number       = {12},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Ligand-induced tyrosine phosphorylation of cysteinyl leukotriene receptor 1 triggers internalization and signaling in intestinal epithelial cells.},
  url          = {http://dx.doi.org/10.1371/journal.pone.0014439},
  volume       = {5},
  year         = {2010},
}