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Serum triglycerides and cancer risk in the metabolic syndrome and cancer (Me-Can) collaborative study

Borena, Wegene; Stocks, Tanja; Jonsson, Hakan; Strohmaier, Susanne; Nagel, Gabriele; Bjorge, Tone; Manjer, Jonas LU ; Hallmans, Goeran; Selmer, Randi and Almquist, Martin LU , et al. (2011) In Cancer Causes and Control 22(2). p.291-299
Abstract
To assess the association between serum triglyceride levels and cancer risk. The metabolic syndrome and cancer project (Me-Can) includes cohorts from Norway, Austria, and Sweden; the current study included data on 257,585 men and 256,512 women. The mean age at study entry was 43.8 years for men and 44.2 years for women. The mean follow-up time was 13.4 years (SD = 8.5) for men and 11.9 years (SD = 7.2) for women. Excluding the first year of follow-up, 23,060 men and 15,686 women were diagnosed with cancer. Cox regression models were used to calculate relative risk (RR) of cancer for triglyceride levels in quintiles and as a continuous variable. RRs were corrected for random error by use of regression dilution ratio. Relative risk for top... (More)
To assess the association between serum triglyceride levels and cancer risk. The metabolic syndrome and cancer project (Me-Can) includes cohorts from Norway, Austria, and Sweden; the current study included data on 257,585 men and 256,512 women. The mean age at study entry was 43.8 years for men and 44.2 years for women. The mean follow-up time was 13.4 years (SD = 8.5) for men and 11.9 years (SD = 7.2) for women. Excluding the first year of follow-up, 23,060 men and 15,686 women were diagnosed with cancer. Cox regression models were used to calculate relative risk (RR) of cancer for triglyceride levels in quintiles and as a continuous variable. RRs were corrected for random error by use of regression dilution ratio. Relative risk for top quintile versus bottom quintile of triglycerides of overall cancer was 1.16 (95% confidence interval 1.06-1.26) in men and 1.15 (1.05-1.27) in women. For specific cancers, significant increases for top quintile versus bottom quintile of triglycerides among men were found for cancers of the colon, respiratory tract, the kidney, melanoma and thyroid and among women, for respiratory, cervical, and non-melanoma skin cancers. Data from our study provided evidence for a possible role of serum triglycerides in cancer development. (Less)
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Contribution to journal
publication status
published
subject
keywords
Lipids, Prospective study, Cancer incidence
in
Cancer Causes and Control
volume
22
issue
2
pages
291 - 299
publisher
Springer
external identifiers
  • wos:000286465000014
  • scopus:79951725594
ISSN
1573-7225
DOI
10.1007/s10552-010-9697-0
language
English
LU publication?
yes
id
3e4b953a-34ab-4d88-8eed-586fed6cc26c (old id 1790825)
date added to LUP
2011-03-02 14:37:43
date last changed
2017-09-03 03:16:41
@article{3e4b953a-34ab-4d88-8eed-586fed6cc26c,
  abstract     = {To assess the association between serum triglyceride levels and cancer risk. The metabolic syndrome and cancer project (Me-Can) includes cohorts from Norway, Austria, and Sweden; the current study included data on 257,585 men and 256,512 women. The mean age at study entry was 43.8 years for men and 44.2 years for women. The mean follow-up time was 13.4 years (SD = 8.5) for men and 11.9 years (SD = 7.2) for women. Excluding the first year of follow-up, 23,060 men and 15,686 women were diagnosed with cancer. Cox regression models were used to calculate relative risk (RR) of cancer for triglyceride levels in quintiles and as a continuous variable. RRs were corrected for random error by use of regression dilution ratio. Relative risk for top quintile versus bottom quintile of triglycerides of overall cancer was 1.16 (95% confidence interval 1.06-1.26) in men and 1.15 (1.05-1.27) in women. For specific cancers, significant increases for top quintile versus bottom quintile of triglycerides among men were found for cancers of the colon, respiratory tract, the kidney, melanoma and thyroid and among women, for respiratory, cervical, and non-melanoma skin cancers. Data from our study provided evidence for a possible role of serum triglycerides in cancer development.},
  author       = {Borena, Wegene and Stocks, Tanja and Jonsson, Hakan and Strohmaier, Susanne and Nagel, Gabriele and Bjorge, Tone and Manjer, Jonas and Hallmans, Goeran and Selmer, Randi and Almquist, Martin and Haggstrom, Christel and Engeland, Anders and Tretli, Steinar and Concin, Hans and Strasak, Alexander and Stattin, Paer and Ulmer, Hanno},
  issn         = {1573-7225},
  keyword      = {Lipids,Prospective study,Cancer incidence},
  language     = {eng},
  number       = {2},
  pages        = {291--299},
  publisher    = {Springer},
  series       = {Cancer Causes and Control},
  title        = {Serum triglycerides and cancer risk in the metabolic syndrome and cancer (Me-Can) collaborative study},
  url          = {http://dx.doi.org/10.1007/s10552-010-9697-0},
  volume       = {22},
  year         = {2011},
}