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Enriched environment downregulates macrophage migration inhibitory factor and increases parvalbumin in the brain following experimental stroke

Inacio, Ana LU ; Ruscher, Karsten LU and Wieloch, Tadeusz LU (2011) In Neurobiology of Disease 41(2). p.270-278
Abstract
Housing rodents in an enriched environment (EE) following experimental stroke enhances neurological recovery. Understanding the underlying neural cues may provide the basis for improving stroke rehabilitation. We studied the contribution of brain macrophage migration inhibitory factor (MIF) to functional recovery after permanent middle cerebral artery occlusion (pMCAo) in rats. In the cerebral cortex, MIF is predominantly found in neurons, particularly in parvalbumin interneurons. Following pMCAo, MIF increases around the infarct core, where it is located to neurons and astrocytes. Housing rats in an EE after pMCAo resulted in a decrease of MIF protein levels in pen-infarct areas, which was accompanied by an increase in parvalbumin... (More)
Housing rodents in an enriched environment (EE) following experimental stroke enhances neurological recovery. Understanding the underlying neural cues may provide the basis for improving stroke rehabilitation. We studied the contribution of brain macrophage migration inhibitory factor (MIF) to functional recovery after permanent middle cerebral artery occlusion (pMCAo) in rats. In the cerebral cortex, MIF is predominantly found in neurons, particularly in parvalbumin interneurons. Following pMCAo, MIF increases around the infarct core, where it is located to neurons and astrocytes. Housing rats in an EE after pMCAo resulted in a decrease of MIF protein levels in pen-infarct areas, which was accompanied by an increase in parvalbumin immunoreactive interneurons. Our data suggest that MIF is part of a signaling network involved in brain plasticity, and elevated neuronal and/or astrocytic MIF levels repress the recovery of sensory-motor function after stroke. Downregulating MIF could constitute a new therapeutic approach to promote recovery after stroke. (C) 2010 Elsevier Inc. All rights reserved. (Less)
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author
organization
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Contribution to journal
publication status
published
subject
keywords
Astrocytes, Enriched environment, Experimental stroke, Functional, recovery, Macrophage migration inhibitory factor, Parvalbumin, Spontaneously hypertensive rats
in
Neurobiology of Disease
volume
41
issue
2
pages
270 - 278
publisher
Elsevier
external identifiers
  • wos:000286154300005
  • scopus:78650628285
ISSN
0969-9961
DOI
10.1016/j.nbd.2010.09.015
language
English
LU publication?
yes
id
0c813925-c93b-44a8-ba6e-bf5ffafc8665 (old id 1790881)
date added to LUP
2011-03-02 13:33:50
date last changed
2017-07-02 03:07:47
@article{0c813925-c93b-44a8-ba6e-bf5ffafc8665,
  abstract     = {Housing rodents in an enriched environment (EE) following experimental stroke enhances neurological recovery. Understanding the underlying neural cues may provide the basis for improving stroke rehabilitation. We studied the contribution of brain macrophage migration inhibitory factor (MIF) to functional recovery after permanent middle cerebral artery occlusion (pMCAo) in rats. In the cerebral cortex, MIF is predominantly found in neurons, particularly in parvalbumin interneurons. Following pMCAo, MIF increases around the infarct core, where it is located to neurons and astrocytes. Housing rats in an EE after pMCAo resulted in a decrease of MIF protein levels in pen-infarct areas, which was accompanied by an increase in parvalbumin immunoreactive interneurons. Our data suggest that MIF is part of a signaling network involved in brain plasticity, and elevated neuronal and/or astrocytic MIF levels repress the recovery of sensory-motor function after stroke. Downregulating MIF could constitute a new therapeutic approach to promote recovery after stroke. (C) 2010 Elsevier Inc. All rights reserved.},
  author       = {Inacio, Ana and Ruscher, Karsten and Wieloch, Tadeusz},
  issn         = {0969-9961},
  keyword      = {Astrocytes,Enriched environment,Experimental stroke,Functional,recovery,Macrophage migration inhibitory factor,Parvalbumin,Spontaneously hypertensive rats},
  language     = {eng},
  number       = {2},
  pages        = {270--278},
  publisher    = {Elsevier},
  series       = {Neurobiology of Disease},
  title        = {Enriched environment downregulates macrophage migration inhibitory factor and increases parvalbumin in the brain following experimental stroke},
  url          = {http://dx.doi.org/10.1016/j.nbd.2010.09.015},
  volume       = {41},
  year         = {2011},
}