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Polyphenolic Constituents and Antioxidant Potential of Geranium stepporum Davis

Sohretoglu, Didem; Sakar, Mahmut Koray; Sabuncuoglu, Suna Atasayar; Ozgunes, Hilal and Sterner, Olov LU (2011) In Records of Natural Products 5(1). p.22-28
Abstract
The crude MeOH extract prepared from the aerial parts of G. stepporum and its EtOAc, n-BuOH, H2O subextracts were screened for their inhibitory activity on H2O2-induced lipid peroxidation in human red blood cells. The EtOAc subextract was found to be the most active one and its chemical composition was further analysed. Six polyphenolic secondary metabolites including quercetin (1), rutin (2), methyl gallate (3), pusilagin (4), 1,3,6-tri-O-galloyl-beta-glucospyranose (5) and 1,2,3,4,6-penta-O-galloyl-beta-glucopyranose (6) were isolated from the EtOAc extract by successive chromatographic methods (Sephadex CC, silica gel CC and P-TLC). The structures of the isolates were elucidated by 1D- and 2D-NMR and MS. This is the first report of... (More)
The crude MeOH extract prepared from the aerial parts of G. stepporum and its EtOAc, n-BuOH, H2O subextracts were screened for their inhibitory activity on H2O2-induced lipid peroxidation in human red blood cells. The EtOAc subextract was found to be the most active one and its chemical composition was further analysed. Six polyphenolic secondary metabolites including quercetin (1), rutin (2), methyl gallate (3), pusilagin (4), 1,3,6-tri-O-galloyl-beta-glucospyranose (5) and 1,2,3,4,6-penta-O-galloyl-beta-glucopyranose (6) were isolated from the EtOAc extract by successive chromatographic methods (Sephadex CC, silica gel CC and P-TLC). The structures of the isolates were elucidated by 1D- and 2D-NMR and MS. This is the first report of occurrence of hydrolysable tannins in G. stepporum. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Geranium stepporum, Geraniaceae, galloylglucopyranose, hydrolysable, tannin, flavonoid, antioxidant effect
in
Records of Natural Products
volume
5
issue
1
pages
22 - 28
publisher
ACG Publications
external identifiers
  • wos:000285645600003
  • scopus:79251587796
ISSN
1307-6167
language
English
LU publication?
yes
id
eba78926-f37d-48fe-8f6c-42b60e047df6 (old id 1791066)
alternative location
http://acgpubs.org/RNP/2011/Volume%205/Issue%201/3-RNP-1005-229.pdf
date added to LUP
2011-03-10 16:23:57
date last changed
2017-01-01 05:32:39
@article{eba78926-f37d-48fe-8f6c-42b60e047df6,
  abstract     = {The crude MeOH extract prepared from the aerial parts of G. stepporum and its EtOAc, n-BuOH, H2O subextracts were screened for their inhibitory activity on H2O2-induced lipid peroxidation in human red blood cells. The EtOAc subextract was found to be the most active one and its chemical composition was further analysed. Six polyphenolic secondary metabolites including quercetin (1), rutin (2), methyl gallate (3), pusilagin (4), 1,3,6-tri-O-galloyl-beta-glucospyranose (5) and 1,2,3,4,6-penta-O-galloyl-beta-glucopyranose (6) were isolated from the EtOAc extract by successive chromatographic methods (Sephadex CC, silica gel CC and P-TLC). The structures of the isolates were elucidated by 1D- and 2D-NMR and MS. This is the first report of occurrence of hydrolysable tannins in G. stepporum.},
  author       = {Sohretoglu, Didem and Sakar, Mahmut Koray and Sabuncuoglu, Suna Atasayar and Ozgunes, Hilal and Sterner, Olov},
  issn         = {1307-6167},
  keyword      = {Geranium stepporum,Geraniaceae,galloylglucopyranose,hydrolysable,tannin,flavonoid,antioxidant effect},
  language     = {eng},
  number       = {1},
  pages        = {22--28},
  publisher    = {ACG Publications},
  series       = {Records of Natural Products},
  title        = {Polyphenolic Constituents and Antioxidant Potential of Geranium stepporum Davis},
  volume       = {5},
  year         = {2011},
}