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Associations between cerebral small vessel disease and reduced forced vital capacity and expiratory volume in a general healthy Swedish elder population study-Good Aging in Skåne

Elmståhl, Sölve LU ; Ellström, Katarina LU ; Månsson, Tomas LU ; Basna, Rani LU orcid ; Siennicki-Lantz, Arkadiusz LU orcid and Abul-Kasim, Kasim LU (2025) In Journal of Alzheimer's disease : JAD
Abstract

BackgroundCerebral small vessel disease (CSVD) is one of the most important causes of cognitive decline. Only a few previous studies have evaluated lung function measures in relation to brain neuropathological changes, and even less studies on specific lesions and areas that could shed light on mechanisms of CSVD.ObjectiveThe aim was to study the association between lung function and CSVD in the general elder population.Methods379 participants, aged 72-87 years from the general population study 'Good Aging in Skåne study (GÅS)'were investigated with a 3 T MRI brain examination and spirometry. Z-scores of FEV1 and FVC were calculated using the GLI 2012 equations. Age-adjusted associations between white matter hyperintensities (WMH),... (More)

BackgroundCerebral small vessel disease (CSVD) is one of the most important causes of cognitive decline. Only a few previous studies have evaluated lung function measures in relation to brain neuropathological changes, and even less studies on specific lesions and areas that could shed light on mechanisms of CSVD.ObjectiveThe aim was to study the association between lung function and CSVD in the general elder population.Methods379 participants, aged 72-87 years from the general population study 'Good Aging in Skåne study (GÅS)'were investigated with a 3 T MRI brain examination and spirometry. Z-scores of FEV1 and FVC were calculated using the GLI 2012 equations. Age-adjusted associations between white matter hyperintensities (WMH), medial temporal lobe atrophy (MTA), lacunar infarction, cerebral atrophies and cerebral microbleeds and lung function were calculated and stratified for sex.ResultsDecreased FEV1 and FVC z-scores below ≤ -1.0 were both associated with increased risk of WMI and global cortical atrophy. Decreased FVC z-scores were also associated with MTA and lacunar infarction in women and precuneus atrophy in men. The associations for WMH, MTA and lacunar infarctions and higher STRIVE score were noted among women, but not among men. FEV1 z scores were not related to diabetes, coronary artery disease or stroke.ConclusionsLower lung function was associated to MRI markers of CSVD in this general healthy population, particularly with WMH, especially for women. Although possible shared risk factors exist between lung and heart disease, lung function should be recognized in future studies on CSVD.

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Contribution to journal
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epub
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in
Journal of Alzheimer's disease : JAD
publisher
SAGE Publications
external identifiers
  • pmid:40267322
ISSN
1387-2877
DOI
10.1177/13872877251333793
language
English
LU publication?
yes
id
17a9faee-c0c2-4414-aab4-93f3faadbf38
date added to LUP
2025-05-21 11:59:38
date last changed
2025-05-21 13:14:37
@article{17a9faee-c0c2-4414-aab4-93f3faadbf38,
  abstract     = {{<p>BackgroundCerebral small vessel disease (CSVD) is one of the most important causes of cognitive decline. Only a few previous studies have evaluated lung function measures in relation to brain neuropathological changes, and even less studies on specific lesions and areas that could shed light on mechanisms of CSVD.ObjectiveThe aim was to study the association between lung function and CSVD in the general elder population.Methods379 participants, aged 72-87 years from the general population study 'Good Aging in Skåne study (GÅS)'were investigated with a 3 T MRI brain examination and spirometry. Z-scores of FEV1 and FVC were calculated using the GLI 2012 equations. Age-adjusted associations between white matter hyperintensities (WMH), medial temporal lobe atrophy (MTA), lacunar infarction, cerebral atrophies and cerebral microbleeds and lung function were calculated and stratified for sex.ResultsDecreased FEV1 and FVC z-scores below ≤ -1.0 were both associated with increased risk of WMI and global cortical atrophy. Decreased FVC z-scores were also associated with MTA and lacunar infarction in women and precuneus atrophy in men. The associations for WMH, MTA and lacunar infarctions and higher STRIVE score were noted among women, but not among men. FEV1 z scores were not related to diabetes, coronary artery disease or stroke.ConclusionsLower lung function was associated to MRI markers of CSVD in this general healthy population, particularly with WMH, especially for women. Although possible shared risk factors exist between lung and heart disease, lung function should be recognized in future studies on CSVD.</p>}},
  author       = {{Elmståhl, Sölve and Ellström, Katarina and Månsson, Tomas and Basna, Rani and Siennicki-Lantz, Arkadiusz and Abul-Kasim, Kasim}},
  issn         = {{1387-2877}},
  language     = {{eng}},
  month        = {{04}},
  publisher    = {{SAGE Publications}},
  series       = {{Journal of Alzheimer's disease : JAD}},
  title        = {{Associations between cerebral small vessel disease and reduced forced vital capacity and expiratory volume in a general healthy Swedish elder population study-Good Aging in Skåne}},
  url          = {{http://dx.doi.org/10.1177/13872877251333793}},
  doi          = {{10.1177/13872877251333793}},
  year         = {{2025}},
}