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Parental cancer as a risk factor for bone cancer : a nation-wide study from Sweden

Li, Xinjun LU and Hemminki, Kari LU (2002) In Journal of Clinical Epidemiology 55(2). p.4-111
Abstract

We used the nation-wide Swedish Family-Cancer Database to analyze the risk for bone cancer in offspring by parental cancers and in siblings of bone cancer probands. Additionally, the risk of second cancer following childhood bone cancer was investigated. In offspring, 1,190 bone cancers were diagnosed between years 1958 and 1996. Groups of offspring were compared by calculating standardized incidence ratios (SIRs) for bone cancer. Most bone cancer cases occurred sporadically. Parental breast (SIR 1.7) and prostate (SIR 1.7) cancers were associated with early-onset (<25 years) osteosarcoma in offspring, probably due to Li-Fraumeni syndrome. Giant cell sarcoma was increased by parental breast cancer (SIR 2.9), and early-onset... (More)

We used the nation-wide Swedish Family-Cancer Database to analyze the risk for bone cancer in offspring by parental cancers and in siblings of bone cancer probands. Additionally, the risk of second cancer following childhood bone cancer was investigated. In offspring, 1,190 bone cancers were diagnosed between years 1958 and 1996. Groups of offspring were compared by calculating standardized incidence ratios (SIRs) for bone cancer. Most bone cancer cases occurred sporadically. Parental breast (SIR 1.7) and prostate (SIR 1.7) cancers were associated with early-onset (<25 years) osteosarcoma in offspring, probably due to Li-Fraumeni syndrome. Giant cell sarcoma was increased by parental breast cancer (SIR 2.9), and early-onset chondrosarcoma by parental kidney cancers (SIR 6.8). Bone cancers conveyed a high risk of second bone and connective tissue cancer.

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author
publishing date
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publication status
published
subject
keywords
Adolescent, Adult, Bone Neoplasms/epidemiology, Child, Child, Preschool, Databases, Factual, Female, Humans, Infant, Male, Middle Aged, Neoplasms, Second Primary/epidemiology, Osteosarcoma/epidemiology, Registries, Risk Factors, Sarcoma, Ewing/epidemiology, Sweden/epidemiology
in
Journal of Clinical Epidemiology
volume
55
issue
2
pages
4 pages
publisher
Elsevier
external identifiers
  • scopus:0036140850
ISSN
0895-4356
DOI
10.1016/S0895-4356(01)00435-8
language
English
LU publication?
no
id
17d9f38b-8ead-48f9-82f5-1442667c7621
date added to LUP
2019-01-30 12:00:41
date last changed
2019-02-21 09:42:02
@article{17d9f38b-8ead-48f9-82f5-1442667c7621,
  abstract     = {<p>We used the nation-wide Swedish Family-Cancer Database to analyze the risk for bone cancer in offspring by parental cancers and in siblings of bone cancer probands. Additionally, the risk of second cancer following childhood bone cancer was investigated. In offspring, 1,190 bone cancers were diagnosed between years 1958 and 1996. Groups of offspring were compared by calculating standardized incidence ratios (SIRs) for bone cancer. Most bone cancer cases occurred sporadically. Parental breast (SIR 1.7) and prostate (SIR 1.7) cancers were associated with early-onset (&lt;25 years) osteosarcoma in offspring, probably due to Li-Fraumeni syndrome. Giant cell sarcoma was increased by parental breast cancer (SIR 2.9), and early-onset chondrosarcoma by parental kidney cancers (SIR 6.8). Bone cancers conveyed a high risk of second bone and connective tissue cancer.</p>},
  author       = {Li, Xinjun and Hemminki, Kari},
  issn         = {0895-4356},
  keyword      = {Adolescent,Adult,Bone Neoplasms/epidemiology,Child,Child, Preschool,Databases, Factual,Female,Humans,Infant,Male,Middle Aged,Neoplasms, Second Primary/epidemiology,Osteosarcoma/epidemiology,Registries,Risk Factors,Sarcoma, Ewing/epidemiology,Sweden/epidemiology},
  language     = {eng},
  number       = {2},
  pages        = {4--111},
  publisher    = {Elsevier},
  series       = {Journal of Clinical Epidemiology},
  title        = {Parental cancer as a risk factor for bone cancer : a nation-wide study from Sweden},
  url          = {http://dx.doi.org/10.1016/S0895-4356(01)00435-8},
  volume       = {55},
  year         = {2002},
}