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Identifiability of pharmacological models for online individualization

Wahlquist, Ylva LU ; Gojak, Amina and Soltesz, Kristian LU orcid (2021) 11th IFAC Symposium on Biological and Medical Systems In IFAC-PapersOnLine 54(15). p.25-30
Abstract
There is a large variability between individuals in the response to anesthetic drugs, that seriously limits the achievable performance of closed-loop controlled drug dosing. Full individualization of patient models based on early clinical response data has been suggested as a means to improve performance with maintained robustness (safety). We use estimation theoretic analysis and realization theory to characterize practical identifiability of the standard pharmacological model structure from anesthetic induction phase data and conclude that such approaches are not practically feasible.
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Individualized anesthesia, Identifiability, Pharmacokinetic/ pharmacodynamic modeling, Sensitivity analysis, Drug delivery
in
IFAC-PapersOnLine
volume
54
issue
15
pages
25 - 30
publisher
IFAC Secretariat
conference name
11th IFAC Symposium on Biological and Medical Systems
conference location
Ghent, Belgium
conference dates
2021-09-19 - 2021-09-22
external identifiers
  • scopus:85120716898
ISSN
2405-8963
DOI
10.1016/j.ifacol.2021.10.226
project
Anesthesia in Closed Loop
Hemodynamic Stabilization
language
English
LU publication?
yes
id
1805a3a2-52e7-46cc-8a8f-f13353aa20ab
date added to LUP
2021-11-03 14:32:36
date last changed
2023-12-01 11:25:23
@article{1805a3a2-52e7-46cc-8a8f-f13353aa20ab,
  abstract     = {{There is a large variability between individuals in the response to anesthetic drugs, that seriously limits the achievable performance of closed-loop controlled drug dosing. Full individualization of patient models based on early clinical response data has been suggested as a means to improve performance with maintained robustness (safety). We use estimation theoretic analysis and realization theory to characterize practical identifiability of the standard pharmacological model structure from anesthetic induction phase data and conclude that such approaches are not practically feasible.}},
  author       = {{Wahlquist, Ylva and Gojak, Amina and Soltesz, Kristian}},
  issn         = {{2405-8963}},
  keywords     = {{Individualized anesthesia; Identifiability; Pharmacokinetic/ pharmacodynamic modeling; Sensitivity analysis; Drug delivery}},
  language     = {{eng}},
  number       = {{15}},
  pages        = {{25--30}},
  publisher    = {{IFAC Secretariat}},
  series       = {{IFAC-PapersOnLine}},
  title        = {{Identifiability of pharmacological models for online individualization}},
  url          = {{https://lup.lub.lu.se/search/files/109256858/pkpdid210726.pdf}},
  doi          = {{10.1016/j.ifacol.2021.10.226}},
  volume       = {{54}},
  year         = {{2021}},
}