Identifiability of pharmacological models for online individualization
(2021) 11th IFAC Symposium on Biological and Medical Systems In IFAC-PapersOnLine 54(15). p.25-30- Abstract
- There is a large variability between individuals in the response to anesthetic drugs, that seriously limits the achievable performance of closed-loop controlled drug dosing. Full individualization of patient models based on early clinical response data has been suggested as a means to improve performance with maintained robustness (safety). We use estimation theoretic analysis and realization theory to characterize practical identifiability of the standard pharmacological model structure from anesthetic induction phase data and conclude that such approaches are not practically feasible.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1805a3a2-52e7-46cc-8a8f-f13353aa20ab
- author
- Wahlquist, Ylva
LU
; Gojak, Amina
and Soltesz, Kristian
LU
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Individualized anesthesia, Identifiability, Pharmacokinetic/ pharmacodynamic modeling, Sensitivity analysis, Drug delivery
- in
- IFAC-PapersOnLine
- volume
- 54
- issue
- 15
- pages
- 25 - 30
- publisher
- IFAC Secretariat
- conference name
- 11th IFAC Symposium on Biological and Medical Systems
- conference location
- Ghent, Belgium
- conference dates
- 2021-09-19 - 2021-09-22
- external identifiers
-
- scopus:85120716898
- ISSN
- 2405-8963
- DOI
- 10.1016/j.ifacol.2021.10.226
- project
- Anesthesia in Closed Loop
- Hemodynamic Stabilization
- language
- English
- LU publication?
- yes
- id
- 1805a3a2-52e7-46cc-8a8f-f13353aa20ab
- date added to LUP
- 2021-11-03 14:32:36
- date last changed
- 2023-12-01 11:25:23
@article{1805a3a2-52e7-46cc-8a8f-f13353aa20ab, abstract = {{There is a large variability between individuals in the response to anesthetic drugs, that seriously limits the achievable performance of closed-loop controlled drug dosing. Full individualization of patient models based on early clinical response data has been suggested as a means to improve performance with maintained robustness (safety). We use estimation theoretic analysis and realization theory to characterize practical identifiability of the standard pharmacological model structure from anesthetic induction phase data and conclude that such approaches are not practically feasible.}}, author = {{Wahlquist, Ylva and Gojak, Amina and Soltesz, Kristian}}, issn = {{2405-8963}}, keywords = {{Individualized anesthesia; Identifiability; Pharmacokinetic/ pharmacodynamic modeling; Sensitivity analysis; Drug delivery}}, language = {{eng}}, number = {{15}}, pages = {{25--30}}, publisher = {{IFAC Secretariat}}, series = {{IFAC-PapersOnLine}}, title = {{Identifiability of pharmacological models for online individualization}}, url = {{https://lup.lub.lu.se/search/files/109256858/pkpdid210726.pdf}}, doi = {{10.1016/j.ifacol.2021.10.226}}, volume = {{54}}, year = {{2021}}, }