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Confirmed association between neonatal phototherapy or neonatal icterus and risk of childhood asthma

Aspberg, Sara; Dahlquist, Gisela; Kahan, Thomas and Källén, Bengt LU (2010) In Pediatric Allergy and Immunology 21(4). p.733-739
Abstract
We have previously demonstrated an association between neonatal phototherapy and/or neonatal icterus and risk of hospitalization for childhood asthma. This study included children who were prescribed anti-asthmatic medication on a population basis to study exposures during the foetal and neonatal period and risk of childhood asthma. The Swedish Medical Birth Register was linked to the Swedish Prescribed Drug Register. Perinatal data for singleton children who were prescribed anti-asthmatic medication (n = 61 256) were compared with corresponding data for all singleton children born in Sweden from 1 January 1990 to 30 June 2003 and surviving to 1 July 2005 (n = 1 338 319). Mantel-Haenszel's odds ratios were calculated after adjustment for... (More)
We have previously demonstrated an association between neonatal phototherapy and/or neonatal icterus and risk of hospitalization for childhood asthma. This study included children who were prescribed anti-asthmatic medication on a population basis to study exposures during the foetal and neonatal period and risk of childhood asthma. The Swedish Medical Birth Register was linked to the Swedish Prescribed Drug Register. Perinatal data for singleton children who were prescribed anti-asthmatic medication (n = 61 256) were compared with corresponding data for all singleton children born in Sweden from 1 January 1990 to 30 June 2003 and surviving to 1 July 2005 (n = 1 338 319). Mantel-Haenszel's odds ratios were calculated after adjustment for various known confounders. Being the first-born child, maternal age above 44 yr, involuntary childlessness for more than 1 yr, maternal smoking during pregnancy, maternal diabetes mellitus of any kind, pre-eclampsia, caesarean section, and instrumental vaginal delivery were all associated with an increased prescription of anti-asthmatic medication during childhood. Preterm birth, low birth weight, being small for gestational age, respiratory problems, mechanical ventilation, and sepsis and/or pneumonia were also associated with increased drug prescriptions. Neonatal phototherapy and/or icterus were risk determinants for children who developed asthma before the age of 12. After controlling for confounders, the odds ratio for phototherapy and/or icterus remained at 1.30 (95% confidence interval 1.16-1.47). In conclusion, this large population-based study confirms an association between some maternal and perinatal factors and childhood asthma, including neonatal phototherapy and/or icterus. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
neonatal, foetal, icterus, phototherapy, Asthma
in
Pediatric Allergy and Immunology
volume
21
issue
4
pages
733 - 739
publisher
Wiley-Blackwell
external identifiers
  • wos:000285997600012
  • scopus:79952474644
ISSN
0905-6157
DOI
10.1111/j.1399-3038.2010.01038.x
language
English
LU publication?
yes
id
2bf7f04a-ae4c-4346-819b-e8b1d5d3b762 (old id 1811393)
date added to LUP
2011-03-02 14:56:17
date last changed
2018-05-29 11:02:00
@article{2bf7f04a-ae4c-4346-819b-e8b1d5d3b762,
  abstract     = {We have previously demonstrated an association between neonatal phototherapy and/or neonatal icterus and risk of hospitalization for childhood asthma. This study included children who were prescribed anti-asthmatic medication on a population basis to study exposures during the foetal and neonatal period and risk of childhood asthma. The Swedish Medical Birth Register was linked to the Swedish Prescribed Drug Register. Perinatal data for singleton children who were prescribed anti-asthmatic medication (n = 61 256) were compared with corresponding data for all singleton children born in Sweden from 1 January 1990 to 30 June 2003 and surviving to 1 July 2005 (n = 1 338 319). Mantel-Haenszel's odds ratios were calculated after adjustment for various known confounders. Being the first-born child, maternal age above 44 yr, involuntary childlessness for more than 1 yr, maternal smoking during pregnancy, maternal diabetes mellitus of any kind, pre-eclampsia, caesarean section, and instrumental vaginal delivery were all associated with an increased prescription of anti-asthmatic medication during childhood. Preterm birth, low birth weight, being small for gestational age, respiratory problems, mechanical ventilation, and sepsis and/or pneumonia were also associated with increased drug prescriptions. Neonatal phototherapy and/or icterus were risk determinants for children who developed asthma before the age of 12. After controlling for confounders, the odds ratio for phototherapy and/or icterus remained at 1.30 (95% confidence interval 1.16-1.47). In conclusion, this large population-based study confirms an association between some maternal and perinatal factors and childhood asthma, including neonatal phototherapy and/or icterus.},
  author       = {Aspberg, Sara and Dahlquist, Gisela and Kahan, Thomas and Källén, Bengt},
  issn         = {0905-6157},
  keyword      = {neonatal,foetal,icterus,phototherapy,Asthma},
  language     = {eng},
  number       = {4},
  pages        = {733--739},
  publisher    = {Wiley-Blackwell},
  series       = {Pediatric Allergy and Immunology},
  title        = {Confirmed association between neonatal phototherapy or neonatal icterus and risk of childhood asthma},
  url          = {http://dx.doi.org/10.1111/j.1399-3038.2010.01038.x},
  volume       = {21},
  year         = {2010},
}