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Physical activity and gain in abdominal adiposity and body weight: prospective cohort study in 288,498 men and women.

Ekelund, Ulf LU ; Besson, Herve; Luan, Jian'an; May, Anne M; Sharp, Stephen J; Brage, Søren; Travier, Noemie; Agudo, Antonio; Slimani, Nadia and Rinaldi, Sabina, et al. (2011) In The American journal of clinical nutrition 93. p.826-835
Abstract
BACKGROUND: The protective effect of physical activity (PA) on abdominal adiposity is unclear. OBJECTIVE: We examined whether PA independently predicted gains in body weight and abdominal adiposity. DESIGN: In a prospective cohort study [the EPIC (European Prospective Investigation into Cancer and Nutrition)], we followed 84,511 men and 203,987 women for 5.1 y. PA was assessed by a validated questionnaire, and individuals were categorized into 4 groups (inactive, moderately inactive, moderately active, and active). Body weight and waist circumference were measured at baseline and self-reported at follow-up. We used multilevel mixed-effects linear regression models and stratified our analyses by sex with adjustments for age, smoking status,... (More)
BACKGROUND: The protective effect of physical activity (PA) on abdominal adiposity is unclear. OBJECTIVE: We examined whether PA independently predicted gains in body weight and abdominal adiposity. DESIGN: In a prospective cohort study [the EPIC (European Prospective Investigation into Cancer and Nutrition)], we followed 84,511 men and 203,987 women for 5.1 y. PA was assessed by a validated questionnaire, and individuals were categorized into 4 groups (inactive, moderately inactive, moderately active, and active). Body weight and waist circumference were measured at baseline and self-reported at follow-up. We used multilevel mixed-effects linear regression models and stratified our analyses by sex with adjustments for age, smoking status, alcohol consumption, educational level, total energy intake, duration of follow-up, baseline body weight, change in body weight, and waist circumference (when applicable). RESULTS: PA significantly predicted a lower waist circumference (in cm) in men (β = -0.045; 95% CI: -0.057, -0.034) and in women (β = -0.035; 95% CI: -0.056, -0.015) independent of baseline body weight, baseline waist circumference, and other confounding factors. The magnitude of associations was materially unchanged after adjustment for change in body weight. PA was not significantly associated with annual weight gain (in kg) in men (β = -0.008; 95% CI: -0.02, 0.003) and women (β = -0.01; 95% CI: -0.02, 0.0006). The odds of becoming obese were reduced by 7% (P < 0.001) and 10% (P < 0.001) for a one-category difference in baseline PA in men and women, respectively. CONCLUSION: Our results suggest that a higher level of PA reduces abdominal adiposity independent of baseline and changes in body weight and is thus a useful strategy for preventing chronic diseases and premature deaths. (Less)
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published
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The American journal of clinical nutrition
volume
93
pages
826 - 835
publisher
American Society for Clinical Nutrition
external identifiers
  • wos:000288531600021
  • pmid:21346093
  • scopus:79953229545
ISSN
1938-3207
DOI
10.3945/ajcn.110.006593
language
English
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yes
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ac1700db-badb-4618-9455-5f6e9dca18fc (old id 1831427)
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http://www.ncbi.nlm.nih.gov/pubmed/21346093?dopt=Abstract
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2011-03-01 17:53:18
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2017-08-13 04:38:01
@article{ac1700db-badb-4618-9455-5f6e9dca18fc,
  abstract     = {BACKGROUND: The protective effect of physical activity (PA) on abdominal adiposity is unclear. OBJECTIVE: We examined whether PA independently predicted gains in body weight and abdominal adiposity. DESIGN: In a prospective cohort study [the EPIC (European Prospective Investigation into Cancer and Nutrition)], we followed 84,511 men and 203,987 women for 5.1 y. PA was assessed by a validated questionnaire, and individuals were categorized into 4 groups (inactive, moderately inactive, moderately active, and active). Body weight and waist circumference were measured at baseline and self-reported at follow-up. We used multilevel mixed-effects linear regression models and stratified our analyses by sex with adjustments for age, smoking status, alcohol consumption, educational level, total energy intake, duration of follow-up, baseline body weight, change in body weight, and waist circumference (when applicable). RESULTS: PA significantly predicted a lower waist circumference (in cm) in men (β = -0.045; 95% CI: -0.057, -0.034) and in women (β = -0.035; 95% CI: -0.056, -0.015) independent of baseline body weight, baseline waist circumference, and other confounding factors. The magnitude of associations was materially unchanged after adjustment for change in body weight. PA was not significantly associated with annual weight gain (in kg) in men (β = -0.008; 95% CI: -0.02, 0.003) and women (β = -0.01; 95% CI: -0.02, 0.0006). The odds of becoming obese were reduced by 7% (P &lt; 0.001) and 10% (P &lt; 0.001) for a one-category difference in baseline PA in men and women, respectively. CONCLUSION: Our results suggest that a higher level of PA reduces abdominal adiposity independent of baseline and changes in body weight and is thus a useful strategy for preventing chronic diseases and premature deaths.},
  author       = {Ekelund, Ulf and Besson, Herve and Luan, Jian'an and May, Anne M and Sharp, Stephen J and Brage, Søren and Travier, Noemie and Agudo, Antonio and Slimani, Nadia and Rinaldi, Sabina and Jenab, Mazda and Norat, Teresa and Mouw, Traci and Rohrmann, Sabine and Kaaks, Rudolf and Bergmann, Manuela M and Boeing, Heiner and Clavel-Chapelon, Françoise and Boutron-Ruault, Marie-Christine and Overvad, Kim and Jakobsen, Marianne Uhre and Johnsen, Nina Føns and Halkjaer, Jytte and Gonzalez, Carlos A and Rodriguez, Laudina and Sanchez, Maria José and Arriola, Larraitz and Barricarte, Aurelio and Navarro, Carmen and Key, Timothy J and Spencer, Elisabeth A and Orfanos, Philippos and Naska, Androniki and Trichopoulou, Antonia and Manjer, Jonas and Lund, Eiliv and Palli, Dominico and Pala, Valeria and Vineis, Paolo and Mattiello, Amalia and Tumino, Rosario and Bueno-de-Mesquita, H Bas and van den Berg, Saskia W and Odysseos, Andreani D and Riboli, Elio and Wareham, Nicolas J and Peeters, Petra H},
  issn         = {1938-3207},
  language     = {eng},
  pages        = {826--835},
  publisher    = {American Society for Clinical Nutrition},
  series       = {The American journal of clinical nutrition},
  title        = {Physical activity and gain in abdominal adiposity and body weight: prospective cohort study in 288,498 men and women.},
  url          = {http://dx.doi.org/10.3945/ajcn.110.006593},
  volume       = {93},
  year         = {2011},
}