The secretome of mesenchymal stem cells: Potential implications for neuroregeneration.
(2013) In Biochimie 95(12). p.2246-2256- Abstract
- Mesenchymal stem cells have shown regenerative properties in many tissues. This feature had originally been ascribed to their multipotency and thus their ability to differentiate into tissue-specific cells. However, many researchers consider the secretome of mesenchymal stem cells the most important player in the observed reparative effects of these cells. In this review, we specifically focus on the potential neuroregenerative effect of mesenchymal stem cells, summarize several possible mechanisms of neuroregeneration and list key factors mediating this effect. We illustrate examples of mesenchymal stem cell treatment in central nervous system disorders including stroke, neurodegenerative disorders (such as Parkinson's disease,... (More)
- Mesenchymal stem cells have shown regenerative properties in many tissues. This feature had originally been ascribed to their multipotency and thus their ability to differentiate into tissue-specific cells. However, many researchers consider the secretome of mesenchymal stem cells the most important player in the observed reparative effects of these cells. In this review, we specifically focus on the potential neuroregenerative effect of mesenchymal stem cells, summarize several possible mechanisms of neuroregeneration and list key factors mediating this effect. We illustrate examples of mesenchymal stem cell treatment in central nervous system disorders including stroke, neurodegenerative disorders (such as Parkinson's disease, Huntington's disease, multiple system atrophy and cerebellar ataxia) and inflammatory disease (such as multiple sclerosis). We specifically highlight studies where mesenchymal stem cells have entered clinical trials. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3955723
- author
- Paul-Visse, Gesine LU and Anisimov, Sergey LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Biochimie
- volume
- 95
- issue
- 12
- pages
- 2246 - 2256
- publisher
- Elsevier
- external identifiers
-
- wos:000327805400007
- pmid:23871834
- scopus:84887818574
- ISSN
- 1638-6183
- DOI
- 10.1016/j.biochi.2013.07.013
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neurology, Lund (013027000), Neuronal Survival (013212041)
- id
- 1842c66d-a844-45c7-bedd-d962dc688f63 (old id 3955723)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23871834?dopt=Abstract
- date added to LUP
- 2016-04-01 10:22:42
- date last changed
- 2022-05-13 08:16:42
@article{1842c66d-a844-45c7-bedd-d962dc688f63,
abstract = {{Mesenchymal stem cells have shown regenerative properties in many tissues. This feature had originally been ascribed to their multipotency and thus their ability to differentiate into tissue-specific cells. However, many researchers consider the secretome of mesenchymal stem cells the most important player in the observed reparative effects of these cells. In this review, we specifically focus on the potential neuroregenerative effect of mesenchymal stem cells, summarize several possible mechanisms of neuroregeneration and list key factors mediating this effect. We illustrate examples of mesenchymal stem cell treatment in central nervous system disorders including stroke, neurodegenerative disorders (such as Parkinson's disease, Huntington's disease, multiple system atrophy and cerebellar ataxia) and inflammatory disease (such as multiple sclerosis). We specifically highlight studies where mesenchymal stem cells have entered clinical trials.}},
author = {{Paul-Visse, Gesine and Anisimov, Sergey}},
issn = {{1638-6183}},
language = {{eng}},
number = {{12}},
pages = {{2246--2256}},
publisher = {{Elsevier}},
series = {{Biochimie}},
title = {{The secretome of mesenchymal stem cells: Potential implications for neuroregeneration.}},
url = {{http://dx.doi.org/10.1016/j.biochi.2013.07.013}},
doi = {{10.1016/j.biochi.2013.07.013}},
volume = {{95}},
year = {{2013}},
}