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Direct or subacute coronary angiography in out-of-hospital cardiac arrest (DISCO)—An initial pilot-study of a randomized clinical trial

Elfwén, Ludvig ; Lagedal, Rickard ; Nordberg, Per ; James, Stefan ; Oldgren, Jonas ; Böhm, Felix ; Lundgren, Peter ; Rylander, Christian ; van der Linden, Jan and Hollenberg, Jacob , et al. (2019) In Resuscitation 139. p.253-261
Abstract

Background: The clinical importance of immediate coronary angiography, with potentially subsequent percutaneous coronary intervention (PCI), in out-of-hospital cardiac arrest (OHCA) patients without ST-elevation on the ECG is unclear. In this study, we assessed feasibility and safety aspects of performing immediate coronary angiography in a pre-specified pilot phase of the ‘DIrect or Subacute Coronary angiography in Out-of-hospital cardiac arrest’ (DISCO) randomized controlled trial (ClinicalTrials.gov ID: NCT02309151). Methods: Resuscitated bystander witnessed OHCA patients >18 years without ST-elevation on the ECG were randomized to immediate coronary angiography versus standard of care. Event times, procedure related adverse... (More)

Background: The clinical importance of immediate coronary angiography, with potentially subsequent percutaneous coronary intervention (PCI), in out-of-hospital cardiac arrest (OHCA) patients without ST-elevation on the ECG is unclear. In this study, we assessed feasibility and safety aspects of performing immediate coronary angiography in a pre-specified pilot phase of the ‘DIrect or Subacute Coronary angiography in Out-of-hospital cardiac arrest’ (DISCO) randomized controlled trial (ClinicalTrials.gov ID: NCT02309151). Methods: Resuscitated bystander witnessed OHCA patients >18 years without ST-elevation on the ECG were randomized to immediate coronary angiography versus standard of care. Event times, procedure related adverse events and safety variables within 7 days were recorded. Results: In total, 79 patients were randomized to immediate angiography (n = 39) or standard of care (n = 40). No major differences in baseline characteristics between the groups were found. There were no differences in the proportion of bleedings and renal failure. Three patients randomized to immediate angiography and six patients randomized to standard care died within 24 h. The median time from EMS arrival to coronary angiography was 135 min in the immediate angiography group. In patients randomized to immediate angiography a culprit lesion was found in 14/38 (36.8%) and PCI was performed in all these patients. In 6/40 (15%) patients randomized to standard of care, coronary angiography was performed before the stipulated 3 days. Conclusion: In this out-of-hospital cardiac arrest population without ST-elevation, randomization to a strategy to perform immediate coronary angiography was feasible although the time window of 120 min from EMS arrival at the scene of the arrest to start of coronary angiography was not achieved. No significant safety issues were reported.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cardiac arrest, Coronary angiography, Out-of-hospital, Percutaneous coronary intervention
in
Resuscitation
volume
139
pages
9 pages
publisher
Elsevier
external identifiers
  • scopus:85065744157
  • pmid:31028826
ISSN
0300-9572
DOI
10.1016/j.resuscitation.2019.04.027
language
English
LU publication?
yes
id
184625f1-9431-42f5-8733-d5a53b382a0d
date added to LUP
2019-05-28 10:05:00
date last changed
2024-06-25 14:34:37
@article{184625f1-9431-42f5-8733-d5a53b382a0d,
  abstract     = {{<p>Background: The clinical importance of immediate coronary angiography, with potentially subsequent percutaneous coronary intervention (PCI), in out-of-hospital cardiac arrest (OHCA) patients without ST-elevation on the ECG is unclear. In this study, we assessed feasibility and safety aspects of performing immediate coronary angiography in a pre-specified pilot phase of the ‘DIrect or Subacute Coronary angiography in Out-of-hospital cardiac arrest’ (DISCO) randomized controlled trial (ClinicalTrials.gov ID: NCT02309151). Methods: Resuscitated bystander witnessed OHCA patients &gt;18 years without ST-elevation on the ECG were randomized to immediate coronary angiography versus standard of care. Event times, procedure related adverse events and safety variables within 7 days were recorded. Results: In total, 79 patients were randomized to immediate angiography (n = 39) or standard of care (n = 40). No major differences in baseline characteristics between the groups were found. There were no differences in the proportion of bleedings and renal failure. Three patients randomized to immediate angiography and six patients randomized to standard care died within 24 h. The median time from EMS arrival to coronary angiography was 135 min in the immediate angiography group. In patients randomized to immediate angiography a culprit lesion was found in 14/38 (36.8%) and PCI was performed in all these patients. In 6/40 (15%) patients randomized to standard of care, coronary angiography was performed before the stipulated 3 days. Conclusion: In this out-of-hospital cardiac arrest population without ST-elevation, randomization to a strategy to perform immediate coronary angiography was feasible although the time window of 120 min from EMS arrival at the scene of the arrest to start of coronary angiography was not achieved. No significant safety issues were reported.</p>}},
  author       = {{Elfwén, Ludvig and Lagedal, Rickard and Nordberg, Per and James, Stefan and Oldgren, Jonas and Böhm, Felix and Lundgren, Peter and Rylander, Christian and van der Linden, Jan and Hollenberg, Jacob and Erlinge, David and Cronberg, Tobias and Jensen, Ulf and Friberg, Hans and Lilja, Gisela and Larsson, Ing Marie and Wallin, Ewa and Rubertsson, Sten and Svensson, Leif}},
  issn         = {{0300-9572}},
  keywords     = {{Cardiac arrest; Coronary angiography; Out-of-hospital; Percutaneous coronary intervention}},
  language     = {{eng}},
  pages        = {{253--261}},
  publisher    = {{Elsevier}},
  series       = {{Resuscitation}},
  title        = {{Direct or subacute coronary angiography in out-of-hospital cardiac arrest (DISCO)—An initial pilot-study of a randomized clinical trial}},
  url          = {{http://dx.doi.org/10.1016/j.resuscitation.2019.04.027}},
  doi          = {{10.1016/j.resuscitation.2019.04.027}},
  volume       = {{139}},
  year         = {{2019}},
}