Sensory nerve terminal activity in severe hypertension as reflected by circulating calcitonin gene-related peptide (CGRP) and substance P
Edvinsson, Lars LU ; Erlinge, David LU
; Ekman, R
and Thulin, Thomas
(1992)
In Blood Pressure
1(4).
p.223-229
- Abstract
- In patients with severe hypertension and in age and sex matched controls the circulating levels of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) and substance P-LI were measured. Samples were taken before medication, after 2-4 weeks and 2-12 months of pharmacological treatment to normotension. In the control group CGRP-LI levels were significantly higher for females than for males. No such relation was seen for substance P-LI. There were no correlations between CGRP-LI, substance P-LI or blood pressure. In the untreated acute hypertensive group there was a significant correlation between circulating levels of CGRP-LI and both diastolic and systolic blood pressure. No such relationship was seen for substance P-LI. The... (More)
- In patients with severe hypertension and in age and sex matched controls the circulating levels of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) and substance P-LI were measured. Samples were taken before medication, after 2-4 weeks and 2-12 months of pharmacological treatment to normotension. In the control group CGRP-LI levels were significantly higher for females than for males. No such relation was seen for substance P-LI. There were no correlations between CGRP-LI, substance P-LI or blood pressure. In the untreated acute hypertensive group there was a significant correlation between circulating levels of CGRP-LI and both diastolic and systolic blood pressure. No such relationship was seen for substance P-LI. The plasma levels of substance P-LI were significantly elevated (2.8 +/- 4.0) compared to controls (1.3 +/- 1.3, pmol/l, mean +/- S.D., p < 0.01). The levels of CGRP-LI did not differ from the control group. After 2-4 weeks of treatment the blood pressure decreased significantly and the plasma levels of substance P-LI were normalized while the CGRP-LI still did not differ from that of controls. After 2-12 months of treatment the blood pressure was still normalized, and the plasma levels of CGRP-LI and substance P-LI were not different from the control group. In the present study there was a positive correlation in hypertensives between the circulating CGRP-LI levels and diastolic and systolic blood pressure and elevated levels of substance P-LI. This would implicate the existence of a dynamic control through which the sensory system may register and damp the pressure response. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1106479
- author
- Edvinsson, Lars
LU
; Erlinge, David
LU
; Ekman, R
and Thulin, Thomas
- organization
- publishing date
- 1992
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- calcitonin gene-related peptide, substance P, hypertension
- in
- Blood Pressure
- volume
- 1
- issue
- 4
- pages
- 223 - 229
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:1285370
- scopus:0027018983
- ISSN
- 0803-7051
- DOI
- 10.3109/08037059209077667
- language
- English
- LU publication?
- yes
- id
- 1857c827-237f-4c9c-bdcf-df90e3a1106c (old id 1106479)
- date added to LUP
- 2016-04-01 12:21:57
- date last changed
- 2021-01-03 10:16:52
@article{1857c827-237f-4c9c-bdcf-df90e3a1106c,
abstract = {{In patients with severe hypertension and in age and sex matched controls the circulating levels of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) and substance P-LI were measured. Samples were taken before medication, after 2-4 weeks and 2-12 months of pharmacological treatment to normotension. In the control group CGRP-LI levels were significantly higher for females than for males. No such relation was seen for substance P-LI. There were no correlations between CGRP-LI, substance P-LI or blood pressure. In the untreated acute hypertensive group there was a significant correlation between circulating levels of CGRP-LI and both diastolic and systolic blood pressure. No such relationship was seen for substance P-LI. The plasma levels of substance P-LI were significantly elevated (2.8 +/- 4.0) compared to controls (1.3 +/- 1.3, pmol/l, mean +/- S.D., p < 0.01). The levels of CGRP-LI did not differ from the control group. After 2-4 weeks of treatment the blood pressure decreased significantly and the plasma levels of substance P-LI were normalized while the CGRP-LI still did not differ from that of controls. After 2-12 months of treatment the blood pressure was still normalized, and the plasma levels of CGRP-LI and substance P-LI were not different from the control group. In the present study there was a positive correlation in hypertensives between the circulating CGRP-LI levels and diastolic and systolic blood pressure and elevated levels of substance P-LI. This would implicate the existence of a dynamic control through which the sensory system may register and damp the pressure response.}},
author = {{Edvinsson, Lars and Erlinge, David and Ekman, R and Thulin, Thomas}},
issn = {{0803-7051}},
keywords = {{calcitonin gene-related peptide; substance P; hypertension}},
language = {{eng}},
number = {{4}},
pages = {{223--229}},
publisher = {{Taylor & Francis}},
series = {{Blood Pressure}},
title = {{Sensory nerve terminal activity in severe hypertension as reflected by circulating calcitonin gene-related peptide (CGRP) and substance P}},
url = {{http://dx.doi.org/10.3109/08037059209077667}},
doi = {{10.3109/08037059209077667}},
volume = {{1}},
year = {{1992}},
}