Benzochromenes from the roots of Bourreria pulchra
(2010) In Phytochemistry Letters 3(1). p.9-12- Abstract
- Two new benzochromenes, (6,6-dimethyl-2-methoxy-6H-benzo[c]chromen-9-yl)methanol (1), and 2-methoxy-6,6-dimethyl-6H-benzo[c]chromen-9-carbaldehyde (2), together with several already known metabolites, were isolated from the root extract of Bourreria pulchra (Boraginaceae). The structures of 1 and 2 were established on the basis of their spectroscopic data. Both were assayed for in vitro antiprotozoan activity, and especially 1 was found to possess significant activity against Leishmania mexicana and Trypanosoma cruzi parasites (IC50 4.6 mu g/mL and 7.5 mu g/mL, respectively). (C) 2009 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1859571
- author
- Erosa-Rejon, Gilda J. ; Yam-Puc, Alejandro ; Chan-Bacab, Manuel J. ; Gimenez-Turbax, Alberto ; Salamanca, Efrain ; Pena-Rodriguez, Luis M. and Sterner, Olov LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Bourreria pulchra, Boraginaceae, Benzochromene, Antiprotozoal, Leishmania mexicana, Trypanosoma cruzi
- in
- Phytochemistry Letters
- volume
- 3
- issue
- 1
- pages
- 9 - 12
- publisher
- Elsevier
- external identifiers
-
- wos:000287846800002
- scopus:77949263050
- ISSN
- 1874-3900
- DOI
- 10.1016/j.phytol.2009.10.002
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
- id
- c5789915-9796-40da-9c59-f03b9e263aa5 (old id 1859571)
- date added to LUP
- 2016-04-01 10:31:11
- date last changed
- 2022-03-27 17:06:08
@article{c5789915-9796-40da-9c59-f03b9e263aa5, abstract = {{Two new benzochromenes, (6,6-dimethyl-2-methoxy-6H-benzo[c]chromen-9-yl)methanol (1), and 2-methoxy-6,6-dimethyl-6H-benzo[c]chromen-9-carbaldehyde (2), together with several already known metabolites, were isolated from the root extract of Bourreria pulchra (Boraginaceae). The structures of 1 and 2 were established on the basis of their spectroscopic data. Both were assayed for in vitro antiprotozoan activity, and especially 1 was found to possess significant activity against Leishmania mexicana and Trypanosoma cruzi parasites (IC50 4.6 mu g/mL and 7.5 mu g/mL, respectively). (C) 2009 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.}}, author = {{Erosa-Rejon, Gilda J. and Yam-Puc, Alejandro and Chan-Bacab, Manuel J. and Gimenez-Turbax, Alberto and Salamanca, Efrain and Pena-Rodriguez, Luis M. and Sterner, Olov}}, issn = {{1874-3900}}, keywords = {{Bourreria pulchra; Boraginaceae; Benzochromene; Antiprotozoal; Leishmania mexicana; Trypanosoma cruzi}}, language = {{eng}}, number = {{1}}, pages = {{9--12}}, publisher = {{Elsevier}}, series = {{Phytochemistry Letters}}, title = {{Benzochromenes from the roots of Bourreria pulchra}}, url = {{http://dx.doi.org/10.1016/j.phytol.2009.10.002}}, doi = {{10.1016/j.phytol.2009.10.002}}, volume = {{3}}, year = {{2010}}, }