Advanced

Benzochromenes from the roots of Bourreria pulchra

Erosa-Rejon, Gilda J.; Yam-Puc, Alejandro; Chan-Bacab, Manuel J.; Gimenez-Turbax, Alberto; Salamanca, Efrain; Pena-Rodriguez, Luis M. and Sterner, Olov LU (2010) In Phytochemistry Letters 3(1). p.9-12
Abstract
Two new benzochromenes, (6,6-dimethyl-2-methoxy-6H-benzo[c]chromen-9-yl)methanol (1), and 2-methoxy-6,6-dimethyl-6H-benzo[c]chromen-9-carbaldehyde (2), together with several already known metabolites, were isolated from the root extract of Bourreria pulchra (Boraginaceae). The structures of 1 and 2 were established on the basis of their spectroscopic data. Both were assayed for in vitro antiprotozoan activity, and especially 1 was found to possess significant activity against Leishmania mexicana and Trypanosoma cruzi parasites (IC50 4.6 mu g/mL and 7.5 mu g/mL, respectively). (C) 2009 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bourreria pulchra, Boraginaceae, Benzochromene, Antiprotozoal, Leishmania mexicana, Trypanosoma cruzi
in
Phytochemistry Letters
volume
3
issue
1
pages
9 - 12
publisher
Elsevier
external identifiers
  • wos:000287846800002
  • scopus:77949263050
ISSN
1874-3900
DOI
10.1016/j.phytol.2009.10.002
language
English
LU publication?
yes
id
c5789915-9796-40da-9c59-f03b9e263aa5 (old id 1859571)
date added to LUP
2011-04-20 09:15:07
date last changed
2018-05-29 09:19:38
@article{c5789915-9796-40da-9c59-f03b9e263aa5,
  abstract     = {Two new benzochromenes, (6,6-dimethyl-2-methoxy-6H-benzo[c]chromen-9-yl)methanol (1), and 2-methoxy-6,6-dimethyl-6H-benzo[c]chromen-9-carbaldehyde (2), together with several already known metabolites, were isolated from the root extract of Bourreria pulchra (Boraginaceae). The structures of 1 and 2 were established on the basis of their spectroscopic data. Both were assayed for in vitro antiprotozoan activity, and especially 1 was found to possess significant activity against Leishmania mexicana and Trypanosoma cruzi parasites (IC50 4.6 mu g/mL and 7.5 mu g/mL, respectively). (C) 2009 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.},
  author       = {Erosa-Rejon, Gilda J. and Yam-Puc, Alejandro and Chan-Bacab, Manuel J. and Gimenez-Turbax, Alberto and Salamanca, Efrain and Pena-Rodriguez, Luis M. and Sterner, Olov},
  issn         = {1874-3900},
  keyword      = {Bourreria pulchra,Boraginaceae,Benzochromene,Antiprotozoal,Leishmania mexicana,Trypanosoma cruzi},
  language     = {eng},
  number       = {1},
  pages        = {9--12},
  publisher    = {Elsevier},
  series       = {Phytochemistry Letters},
  title        = {Benzochromenes from the roots of Bourreria pulchra},
  url          = {http://dx.doi.org/10.1016/j.phytol.2009.10.002},
  volume       = {3},
  year         = {2010},
}