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Cardiovascular Diseases and Hippocampal Infarcts

Rauramaa, Tuomas; Pikkarainen, Maria; Englund, Elisabet LU ; Ince, Paul G.; Jellinger, Kurt; Paetau, Anders; Parkkinen, Laura and Alafuzoff, Irina (2011) In Hippocampus 21(3). p.281-287
Abstract
The prevalence of hippocampal lesions such as hippocampal infarcts have not been studied in detail even though hippocampal alterations are known to be associated with various clinical conditions such as age-related degenerative disorders and epilepsy. Methods: Here we defined the hippocampal infarcts and assessed the prevalence of this lesion in large unselected population of 1,245 subjects age ranging from 1 to 99 years (mean age 79 +/- 1 S. E. M). Furthermore, we assessed the association of these lesions with various cardio-and cerebro-vascular disorders and other neurodegenerative lesions. The prevalence of hippocampal infarct in the study population of 1,245 subjects was 12%, increasing to 13% when only those with a clinically... (More)
The prevalence of hippocampal lesions such as hippocampal infarcts have not been studied in detail even though hippocampal alterations are known to be associated with various clinical conditions such as age-related degenerative disorders and epilepsy. Methods: Here we defined the hippocampal infarcts and assessed the prevalence of this lesion in large unselected population of 1,245 subjects age ranging from 1 to 99 years (mean age 79 +/- 1 S. E. M). Furthermore, we assessed the association of these lesions with various cardio-and cerebro-vascular disorders and other neurodegenerative lesions. The prevalence of hippocampal infarct in the study population of 1,245 subjects was 12%, increasing to 13% when only those with a clinically diagnosed cognitive impairment (n = 311) were analyzed. Large hemispheric brain infarcts were seen in 31% of the study subjects and these lesions were strongly associated with cardiovascular risk factors such as hypertension (43%), coronary disease (32%), myocardial infarct (22%), atrial fibrillation (20%), and heart failure (20%). In contrast, hippocampal infarcts displayed a significant association only with large hemispheric brain infarct, heart failure, and cardiovascular index as assessed postmortem. It is noteworthy that only widespread hippocampal infarcts were associated with clinical symptoms of cognitive impairment or epilepsy. The surprisingly low prevalence of 12% of hippocampal infarcts in aged population found here and the failure to detect an association between this lesion and various cerebro-cardio-vascular lesions is intriguing. Whether susceptibility to ischemia in line with susceptibility to neuronal degeneration in this region is influenced by still undetermined risk-factors need further investigation. Furthermore it should be noted that the size of the hippocampal tissue damage, i.e., small vs. large cystic infarcts is of significance regarding clinical alterations. (C) 2010 Wiley-Liss, Inc. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
postmortem study, histology, hippocampus, infarct, cardiovascular, disease
in
Hippocampus
volume
21
issue
3
pages
281 - 287
publisher
John Wiley & Sons
external identifiers
  • wos:000288033600006
  • scopus:79951938540
ISSN
1050-9631
DOI
10.1002/hipo.20747
language
English
LU publication?
yes
id
eccf6126-1394-4efd-8c47-4829fec77fdd (old id 1869294)
date added to LUP
2011-04-04 09:17:30
date last changed
2017-07-30 03:12:49
@article{eccf6126-1394-4efd-8c47-4829fec77fdd,
  abstract     = {The prevalence of hippocampal lesions such as hippocampal infarcts have not been studied in detail even though hippocampal alterations are known to be associated with various clinical conditions such as age-related degenerative disorders and epilepsy. Methods: Here we defined the hippocampal infarcts and assessed the prevalence of this lesion in large unselected population of 1,245 subjects age ranging from 1 to 99 years (mean age 79 +/- 1 S. E. M). Furthermore, we assessed the association of these lesions with various cardio-and cerebro-vascular disorders and other neurodegenerative lesions. The prevalence of hippocampal infarct in the study population of 1,245 subjects was 12%, increasing to 13% when only those with a clinically diagnosed cognitive impairment (n = 311) were analyzed. Large hemispheric brain infarcts were seen in 31% of the study subjects and these lesions were strongly associated with cardiovascular risk factors such as hypertension (43%), coronary disease (32%), myocardial infarct (22%), atrial fibrillation (20%), and heart failure (20%). In contrast, hippocampal infarcts displayed a significant association only with large hemispheric brain infarct, heart failure, and cardiovascular index as assessed postmortem. It is noteworthy that only widespread hippocampal infarcts were associated with clinical symptoms of cognitive impairment or epilepsy. The surprisingly low prevalence of 12% of hippocampal infarcts in aged population found here and the failure to detect an association between this lesion and various cerebro-cardio-vascular lesions is intriguing. Whether susceptibility to ischemia in line with susceptibility to neuronal degeneration in this region is influenced by still undetermined risk-factors need further investigation. Furthermore it should be noted that the size of the hippocampal tissue damage, i.e., small vs. large cystic infarcts is of significance regarding clinical alterations. (C) 2010 Wiley-Liss, Inc.},
  author       = {Rauramaa, Tuomas and Pikkarainen, Maria and Englund, Elisabet and Ince, Paul G. and Jellinger, Kurt and Paetau, Anders and Parkkinen, Laura and Alafuzoff, Irina},
  issn         = {1050-9631},
  keyword      = {postmortem study,histology,hippocampus,infarct,cardiovascular,disease},
  language     = {eng},
  number       = {3},
  pages        = {281--287},
  publisher    = {John Wiley & Sons},
  series       = {Hippocampus},
  title        = {Cardiovascular Diseases and Hippocampal Infarcts},
  url          = {http://dx.doi.org/10.1002/hipo.20747},
  volume       = {21},
  year         = {2011},
}