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Red Meat, Dietary Nitrosamines, and Heme Iron and Risk of Bladder Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Jakszyn, Paula; Gonzalez, Carlos A.; Lujan-Barroso, Leila; Ros, Martine M.; Bueno-de-Mesquita, H. Bas; Roswall, Nina; Tjonneland, Anne M.; Buchner, Frederike L.; Egevad, Lars and Overvad, Kim, et al. (2011) In Cancer Epidemiology Biomarkers & Prevention 20(3). p.555-559
Abstract
Background: Previous epidemiologic studies found inconsistent results for the association between red meat intake, nitrosamines [NDMA: N-nitrosodimethylamine, and ENOC (endogenous nitroso compounds)], and the risk of bladder cancer. We investigated the association between red meat consumption, dietary nitrosamines, and heme iron and the risk of bladder cancer among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Data on food consumption and complete follow-up for cancer occurrence were available for a total of 481,419 participants, recruited in 10 European countries. Estimates of HRs were obtained by proportional hazard models, stratified by age at recruitment, gender, and study center and... (More)
Background: Previous epidemiologic studies found inconsistent results for the association between red meat intake, nitrosamines [NDMA: N-nitrosodimethylamine, and ENOC (endogenous nitroso compounds)], and the risk of bladder cancer. We investigated the association between red meat consumption, dietary nitrosamines, and heme iron and the risk of bladder cancer among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Data on food consumption and complete follow-up for cancer occurrence were available for a total of 481,419 participants, recruited in 10 European countries. Estimates of HRs were obtained by proportional hazard models, stratified by age at recruitment, gender, and study center and adjusted for total energy intake, smoking status, lifetime intensity of smoking, duration of smoking, educational level, and BMI. Results: After a mean follow-up of 8.7 years, 1,001 participants were diagnosed with bladder cancer. We found no overall association between intake of red meat (log(2) HR: 1.06; 95% CI: 0.99-1.13), nitrosamines (log(2) HR: 1.09; 95% CI: 0.92-1.30 and HR: 0.98; 95% CI: 0.92-1.05 for ENOC and NDMA, respectively) or heme iron (log(2) HR: 1.05; 95 CI: 0.99-1.12) and bladder cancer risk. The associations did not vary by sex, high-versus low-risk bladder cancers, smoking status, or occupation (high vs. low risk). Conclusions: Our findings do not support an effect of red meat intake, nitrosamines (endogenous or exogenous), or heme iron intake on bladder cancer risk. Cancer Epidemiol Biomarkers Prev; 20(3); 555-9. (C)2011 AACR. (Less)
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Cancer Epidemiology Biomarkers & Prevention
volume
20
issue
3
pages
555 - 559
publisher
American Association for Cancer Research
external identifiers
  • wos:000288067200018
  • scopus:79955759199
ISSN
1538-7755
DOI
10.1158/1055-9965.EPI-10-0971
language
English
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yes
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080377dc-01dd-4f8c-b648-0594a388e9b4 (old id 1869900)
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2011-04-04 08:37:50
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2017-05-21 03:58:37
@misc{080377dc-01dd-4f8c-b648-0594a388e9b4,
  abstract     = {Background: Previous epidemiologic studies found inconsistent results for the association between red meat intake, nitrosamines [NDMA: N-nitrosodimethylamine, and ENOC (endogenous nitroso compounds)], and the risk of bladder cancer. We investigated the association between red meat consumption, dietary nitrosamines, and heme iron and the risk of bladder cancer among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Data on food consumption and complete follow-up for cancer occurrence were available for a total of 481,419 participants, recruited in 10 European countries. Estimates of HRs were obtained by proportional hazard models, stratified by age at recruitment, gender, and study center and adjusted for total energy intake, smoking status, lifetime intensity of smoking, duration of smoking, educational level, and BMI. Results: After a mean follow-up of 8.7 years, 1,001 participants were diagnosed with bladder cancer. We found no overall association between intake of red meat (log(2) HR: 1.06; 95% CI: 0.99-1.13), nitrosamines (log(2) HR: 1.09; 95% CI: 0.92-1.30 and HR: 0.98; 95% CI: 0.92-1.05 for ENOC and NDMA, respectively) or heme iron (log(2) HR: 1.05; 95 CI: 0.99-1.12) and bladder cancer risk. The associations did not vary by sex, high-versus low-risk bladder cancers, smoking status, or occupation (high vs. low risk). Conclusions: Our findings do not support an effect of red meat intake, nitrosamines (endogenous or exogenous), or heme iron intake on bladder cancer risk. Cancer Epidemiol Biomarkers Prev; 20(3); 555-9. (C)2011 AACR.},
  author       = {Jakszyn, Paula and Gonzalez, Carlos A. and Lujan-Barroso, Leila and Ros, Martine M. and Bueno-de-Mesquita, H. Bas and Roswall, Nina and Tjonneland, Anne M. and Buchner, Frederike L. and Egevad, Lars and Overvad, Kim and Raaschou-Nielsen, Ole and Clavel-Chapelon, Francoise and Boutron-Ruault, Marie-Christine and Touillaud, Marina S. and Chang-Claude, Jenny and Allen, Naomi E. and Kiemeney, Lambertus A. and Key, Timothy J. and Kaaks, Rudolf and Boeing, Heiner and Weikert, Steffen and Trichopoulou, Antonia and Oikonomou, Eleni and Zylis, Dimosthenis and Palli, Domenico and Berrino, Franco and Vineis, Paolo and Tumino, Rosario and Mattiello, Amalia and Peeters, Petra H. M. and Parr, Christine L. and Gram, Inger T. and Skeie, Guri and Sanchez, Maria-Jose and Larranaga, Nerea and Ardanaz, Eva and Navarro, Carmen and Rodriguez, Laudina and Ulmert, David and Ehrnström, Roy and Hallmans, Goran and Ljungberg, Borje and Roddam, Andrew Wilfred and Bingham, Sheila A. and Khaw, Kay-Tee and Slimani, Nadia and Boffetta, Paolo A. and Jenab, Mazda and Mouw, Traci and Michaud, Dominique S. and Riboli, Elio},
  issn         = {1538-7755},
  language     = {eng},
  number       = {3},
  pages        = {555--559},
  publisher    = {American Association for Cancer Research},
  series       = {Cancer Epidemiology Biomarkers & Prevention},
  title        = {Red Meat, Dietary Nitrosamines, and Heme Iron and Risk of Bladder Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)},
  url          = {http://dx.doi.org/10.1158/1055-9965.EPI-10-0971},
  volume       = {20},
  year         = {2011},
}