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CT lung densitometry in young adults with alpha-1-antitrypsin deficiency

Bernspang, Elisabeth; Diaz, Sandra LU ; Stoel, Berend; Wollmer, Per LU ; Sveger, Tomas LU and Piitulainen, Eeva LU (2011) In Respiratory Medicine 105(1). p.74-79
Abstract
Background: Severe (PiZZ) and moderate (PiSZ) alpha-1-antitrypsin (AAT) deficiency predispose to lung emphysema, especially in smokers. We hypothesized that multi-slice computed tomography (CT) might be superior to pulmonary function tests (PFT) to detect lung emphysema in AAT-deficient individuals at the age of 32 years. Methods: A subgroup of PiZZ and PiSZ individuals identified during the Swedish newborn screening programme in 1972-74 underwent multi-slice CT and PFT at the age of 32 years. From the CT scans the percentile density at 15% (PD15) and the relative area below -910 Hounsfield Units (RA(-910) HU) were calculated. The results of PFT and CT were compared between the AAT-deficient individuals and an age-matched control group.... (More)
Background: Severe (PiZZ) and moderate (PiSZ) alpha-1-antitrypsin (AAT) deficiency predispose to lung emphysema, especially in smokers. We hypothesized that multi-slice computed tomography (CT) might be superior to pulmonary function tests (PFT) to detect lung emphysema in AAT-deficient individuals at the age of 32 years. Methods: A subgroup of PiZZ and PiSZ individuals identified during the Swedish newborn screening programme in 1972-74 underwent multi-slice CT and PFT at the age of 32 years. From the CT scans the percentile density at 15% (PD15) and the relative area below -910 Hounsfield Units (RA(-910) HU) were calculated. The results of PFT and CT were compared between the AAT-deficient individuals and an age-matched control group. Results: Twenty-five PiZZ, 11 PiSZ and 17 PiMM individuals participated in the study. All Pi subgroups had normal lung function. The mean PD15 was 81 (SD 22) g/L in the PiZZ individuals, 96 (SD 35) g/L in the PiSZ individuals and 79 (SD 17) g/L in the PiMM individuals (ns), and the RA-910 were 30 (SD 18)%, 24 (SD 20)%, and 32 (SD 18)%, respectively (ns). For the never-smoker subgroups, in the PiZZ (n = 23), PiSZ (n = 8) and PiMM (n = 12), the mean PD15 were 95 (SD 35) g/L, 81 (SD 22) g/L, and 75 (SD 12) g/L, respectively (ns). PD15 was significantly correlated to CT derived lung size (r = -0.72; p < 0.001). Conclusions: CT densitometry revealed no signs of emphysema and no differences between the AAT-deficient individuals identified by neonatal screening and age-matched control subjects. (C) 2010 Elsevier Ltd. All rights reserved, (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alpha-1-antitrypsin deficiency, CT densitometry, COPD, Emphysema, Screening
in
Respiratory Medicine
volume
105
issue
1
pages
74 - 79
publisher
Elsevier
external identifiers
  • wos:000286863500012
  • scopus:78649952157
ISSN
1532-3064
DOI
10.1016/j.rmed.2010.06.016
language
English
LU publication?
yes
id
23bc97b5-44c3-44d9-8ce7-616d5254f6f0 (old id 1870055)
date added to LUP
2011-04-04 08:25:49
date last changed
2017-11-12 03:46:56
@article{23bc97b5-44c3-44d9-8ce7-616d5254f6f0,
  abstract     = {Background: Severe (PiZZ) and moderate (PiSZ) alpha-1-antitrypsin (AAT) deficiency predispose to lung emphysema, especially in smokers. We hypothesized that multi-slice computed tomography (CT) might be superior to pulmonary function tests (PFT) to detect lung emphysema in AAT-deficient individuals at the age of 32 years. Methods: A subgroup of PiZZ and PiSZ individuals identified during the Swedish newborn screening programme in 1972-74 underwent multi-slice CT and PFT at the age of 32 years. From the CT scans the percentile density at 15% (PD15) and the relative area below -910 Hounsfield Units (RA(-910) HU) were calculated. The results of PFT and CT were compared between the AAT-deficient individuals and an age-matched control group. Results: Twenty-five PiZZ, 11 PiSZ and 17 PiMM individuals participated in the study. All Pi subgroups had normal lung function. The mean PD15 was 81 (SD 22) g/L in the PiZZ individuals, 96 (SD 35) g/L in the PiSZ individuals and 79 (SD 17) g/L in the PiMM individuals (ns), and the RA-910 were 30 (SD 18)%, 24 (SD 20)%, and 32 (SD 18)%, respectively (ns). For the never-smoker subgroups, in the PiZZ (n = 23), PiSZ (n = 8) and PiMM (n = 12), the mean PD15 were 95 (SD 35) g/L, 81 (SD 22) g/L, and 75 (SD 12) g/L, respectively (ns). PD15 was significantly correlated to CT derived lung size (r = -0.72; p &lt; 0.001). Conclusions: CT densitometry revealed no signs of emphysema and no differences between the AAT-deficient individuals identified by neonatal screening and age-matched control subjects. (C) 2010 Elsevier Ltd. All rights reserved,},
  author       = {Bernspang, Elisabeth and Diaz, Sandra and Stoel, Berend and Wollmer, Per and Sveger, Tomas and Piitulainen, Eeva},
  issn         = {1532-3064},
  keyword      = {Alpha-1-antitrypsin deficiency,CT densitometry,COPD,Emphysema,Screening},
  language     = {eng},
  number       = {1},
  pages        = {74--79},
  publisher    = {Elsevier},
  series       = {Respiratory Medicine},
  title        = {CT lung densitometry in young adults with alpha-1-antitrypsin deficiency},
  url          = {http://dx.doi.org/10.1016/j.rmed.2010.06.016},
  volume       = {105},
  year         = {2011},
}