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Infection with Hepatitis B and C Viruses and Risk of Lymphoid Malignancies in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Franceschi, Silvia; Lise, Mauro; Trepo, Christian; Berthillon, Pascale; Chuang, Shu-Chun; Nieters, Alexandra; Travis, Ruth C.; Vermeulen, Roel; Overvad, Kim and Tjonneland, Anne, et al. (2011) In Cancer Epidemiology Biomarkers & Prevention 20(1). p.208-214
Abstract
Background: Case-control studies suggested a moderate, but consistent, association of hepatitis C virus (HCV) infection with lymphoid tissue malignancies, especially non-Hodgkin lymphoma (NHL). More limited data suggested that hepatitis B virus (HBV) infection might also be associated with NHL. However, prospective studies on the topic are few. Methods: A nested case-control study was conducted in eight countries participating in the EPIC prospective study. Seven hundred thirty-nine incident cases of NHL, 238 multiple myeloma (MM), and 46 Hodgkin lymphoma (HL) were matched with 2,028 controls. Seropositivity to anti-HCV, anti-HBc, and HBsAg was evaluated and conditional logistic regression was used to estimate odds ratios (OR) and... (More)
Background: Case-control studies suggested a moderate, but consistent, association of hepatitis C virus (HCV) infection with lymphoid tissue malignancies, especially non-Hodgkin lymphoma (NHL). More limited data suggested that hepatitis B virus (HBV) infection might also be associated with NHL. However, prospective studies on the topic are few. Methods: A nested case-control study was conducted in eight countries participating in the EPIC prospective study. Seven hundred thirty-nine incident cases of NHL, 238 multiple myeloma (MM), and 46 Hodgkin lymphoma (HL) were matched with 2,028 controls. Seropositivity to anti-HCV, anti-HBc, and HBsAg was evaluated and conditional logistic regression was used to estimate odds ratios (OR) and corresponding 95% confidence intervals (CI) for NHL, MM, or HL, and their combination. Results: Anti-HCV seropositivity among controls in different countries ranged from 0% to 5.3%; HBsAg from 0% to 2.7%; and anti-HBc from 1.9% to 45.9%. Similar nonsignificant associations were found with seropositivity to HBsAg forNHL (OR = 1.78; 95% CI: 0.78-4.04), MM(OR = 4.00; 95% CI: 1.00-16.0), and HL(OR = 2.00; 95% CI: 0.13-32.0). The association between HBsAg and the combination of NHL, MM, and HL(OR = 2.21; 95% CI: 1.124.33) was similar for cancer diagnosed less than 3 and 3 or more years after blood collection. No significant association was found between anti-HCV and NHL, MM, or HL risk, but the corresponding CIs were very broad. Conclusions: Chronic HBV infection may increase the risk of lymphoid malignancies among healthy European volunteers. Impact: Treatment directed at control of HBV infection should be evaluated in HBsAg-seropositive patients with lymphoid tissue malignancies. Cancer Epidemiol Biomarkers Prev; 20(1); 208-14. (C) 2011 AACR. (Less)
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Cancer Epidemiology Biomarkers & Prevention
volume
20
issue
1
pages
208 - 214
publisher
American Association for Cancer Research
external identifiers
  • wos:000285972800022
  • scopus:78651457456
ISSN
1538-7755
DOI
10.1158/1055-9965.EPI-10-0889
language
English
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yes
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8e7eceab-5eb8-444f-ae0a-3a360c272d89 (old id 1876314)
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2011-04-01 12:02:36
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2017-07-09 04:05:44
@article{8e7eceab-5eb8-444f-ae0a-3a360c272d89,
  abstract     = {Background: Case-control studies suggested a moderate, but consistent, association of hepatitis C virus (HCV) infection with lymphoid tissue malignancies, especially non-Hodgkin lymphoma (NHL). More limited data suggested that hepatitis B virus (HBV) infection might also be associated with NHL. However, prospective studies on the topic are few. Methods: A nested case-control study was conducted in eight countries participating in the EPIC prospective study. Seven hundred thirty-nine incident cases of NHL, 238 multiple myeloma (MM), and 46 Hodgkin lymphoma (HL) were matched with 2,028 controls. Seropositivity to anti-HCV, anti-HBc, and HBsAg was evaluated and conditional logistic regression was used to estimate odds ratios (OR) and corresponding 95% confidence intervals (CI) for NHL, MM, or HL, and their combination. Results: Anti-HCV seropositivity among controls in different countries ranged from 0% to 5.3%; HBsAg from 0% to 2.7%; and anti-HBc from 1.9% to 45.9%. Similar nonsignificant associations were found with seropositivity to HBsAg forNHL (OR = 1.78; 95% CI: 0.78-4.04), MM(OR = 4.00; 95% CI: 1.00-16.0), and HL(OR = 2.00; 95% CI: 0.13-32.0). The association between HBsAg and the combination of NHL, MM, and HL(OR = 2.21; 95% CI: 1.124.33) was similar for cancer diagnosed less than 3 and 3 or more years after blood collection. No significant association was found between anti-HCV and NHL, MM, or HL risk, but the corresponding CIs were very broad. Conclusions: Chronic HBV infection may increase the risk of lymphoid malignancies among healthy European volunteers. Impact: Treatment directed at control of HBV infection should be evaluated in HBsAg-seropositive patients with lymphoid tissue malignancies. Cancer Epidemiol Biomarkers Prev; 20(1); 208-14. (C) 2011 AACR.},
  author       = {Franceschi, Silvia and Lise, Mauro and Trepo, Christian and Berthillon, Pascale and Chuang, Shu-Chun and Nieters, Alexandra and Travis, Ruth C. and Vermeulen, Roel and Overvad, Kim and Tjonneland, Anne and Olsen, Anja and Bergmann, Manuela M. and Boeing, Heiner and Kaaks, Rudolf and Becker, Nikolaus and Trichopoulou, Antonia and Lagiou, Pagona and Bamia, Christina and Palli, Domenico and Sieri, Sabina and Panico, Salvatore and Tumino, Rosario and Sacerdote, Carlotta and Bueno-de-Mesquita, Bas and Peeters, Petra H. M. and Rodriguez, Laudina and Lujan Barroso, Leila and Dorronsoro, Miren and Sanchez, Maria-Jose and Navarro, Carmen and Barricarte, Aurelio and Regnér, Sara and Borgquist, Signe and Melin, Beatrice and Hallmans, Goran and Khaw, Kay-Tee and Wareham, Nick and Rinaldi, Sabina and Hainaut, Pierre and Riboli, Elio and Vineis, Paolo},
  issn         = {1538-7755},
  language     = {eng},
  number       = {1},
  pages        = {208--214},
  publisher    = {American Association for Cancer Research},
  series       = {Cancer Epidemiology Biomarkers & Prevention},
  title        = {Infection with Hepatitis B and C Viruses and Risk of Lymphoid Malignancies in the European Prospective Investigation into Cancer and Nutrition (EPIC)},
  url          = {http://dx.doi.org/10.1158/1055-9965.EPI-10-0889},
  volume       = {20},
  year         = {2011},
}