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Hormonal factors and pancreatic cancer risk in women : The Malmö Diet and Cancer Study

Andersson, Gustav LU ; Borgquist, Signe LU and Jirström, Karin LU (2018) In International Journal of Cancer 143(1). p.52-62
Abstract

The incidence of pancreatic cancer is leveling between sexes. Smoking, high age and heredity are established risk factors, but evidence regarding the influence of hormonal factors is unclear. In this study, we investigated the associations of reproductive factors, use of oral contraceptives (OC) and hormone replacement therapy (HRT) with pancreatic cancer risk in the Malmö Diet and Cancer Study, a prospective, population-based cohort encompassing 17,035 women. Up until 31 December 2015, 110 women were identified with incident pancreatic cancer through the Swedish Cancer Registry. Higher age at menarche was significantly associated with pancreatic cancer risk (age-adjusted [hazard ratio] HR = 1.17; 95% confidence interval [CI] 1.04–1.32,... (More)

The incidence of pancreatic cancer is leveling between sexes. Smoking, high age and heredity are established risk factors, but evidence regarding the influence of hormonal factors is unclear. In this study, we investigated the associations of reproductive factors, use of oral contraceptives (OC) and hormone replacement therapy (HRT) with pancreatic cancer risk in the Malmö Diet and Cancer Study, a prospective, population-based cohort encompassing 17,035 women. Up until 31 December 2015, 110 women were identified with incident pancreatic cancer through the Swedish Cancer Registry. Higher age at menarche was significantly associated with pancreatic cancer risk (age-adjusted [hazard ratio] HR = 1.17; 95% confidence interval [CI] 1.04–1.32, and fully adjusted HR = 1.17; 95% CI 1.04–1.32). Ever use of OC was not significantly associated with pancreatic cancer risk but ever use of HRT was significantly associated with a decreased risk of pancreatic cancer (age-adjusted HR = 0.47, 95% CI 0.23–0.97, and fully adjusted HR = 0.48, 95% CI 0.23–1.00), in particular use of estrogen-only regimen (age-adjusted HR = 0.21; 95% CI 0.05–0.87 and fully adjusted HR = 0.22; 95% CI 0.05–0.90). Age at menopause or first childbirth, parity and breastfeeding history were not significantly associated with pancreatic cancer risk. Collectively, these findings suggest a protective role of female hormones against pancreatic cancer. Further studies are needed, and potential modifying genetic factors and indirect hazardous effects of smoking should also be considered.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
hormone replacement therapy, oral contraceptives, pancreatic cancer risk, reproductive factors
in
International Journal of Cancer
volume
143
issue
1
pages
11 pages
publisher
John Wiley & Sons
external identifiers
  • scopus:85042214512
ISSN
0020-7136
DOI
10.1002/ijc.31302
language
English
LU publication?
yes
id
18781fc1-86a6-4dfe-a299-8f46edee3b0a
date added to LUP
2018-05-22 13:28:40
date last changed
2019-02-20 11:17:28
@article{18781fc1-86a6-4dfe-a299-8f46edee3b0a,
  abstract     = {<p>The incidence of pancreatic cancer is leveling between sexes. Smoking, high age and heredity are established risk factors, but evidence regarding the influence of hormonal factors is unclear. In this study, we investigated the associations of reproductive factors, use of oral contraceptives (OC) and hormone replacement therapy (HRT) with pancreatic cancer risk in the Malmö Diet and Cancer Study, a prospective, population-based cohort encompassing 17,035 women. Up until 31 December 2015, 110 women were identified with incident pancreatic cancer through the Swedish Cancer Registry. Higher age at menarche was significantly associated with pancreatic cancer risk (age-adjusted [hazard ratio] HR = 1.17; 95% confidence interval [CI] 1.04–1.32, and fully adjusted HR = 1.17; 95% CI 1.04–1.32). Ever use of OC was not significantly associated with pancreatic cancer risk but ever use of HRT was significantly associated with a decreased risk of pancreatic cancer (age-adjusted HR = 0.47, 95% CI 0.23–0.97, and fully adjusted HR = 0.48, 95% CI 0.23–1.00), in particular use of estrogen-only regimen (age-adjusted HR = 0.21; 95% CI 0.05–0.87 and fully adjusted HR = 0.22; 95% CI 0.05–0.90). Age at menopause or first childbirth, parity and breastfeeding history were not significantly associated with pancreatic cancer risk. Collectively, these findings suggest a protective role of female hormones against pancreatic cancer. Further studies are needed, and potential modifying genetic factors and indirect hazardous effects of smoking should also be considered.</p>},
  author       = {Andersson, Gustav and Borgquist, Signe and Jirström, Karin},
  issn         = {0020-7136},
  keyword      = {hormone replacement therapy,oral contraceptives,pancreatic cancer risk,reproductive factors},
  language     = {eng},
  month        = {07},
  number       = {1},
  pages        = {52--62},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Hormonal factors and pancreatic cancer risk in women : The Malmö Diet and Cancer Study},
  url          = {http://dx.doi.org/10.1002/ijc.31302},
  volume       = {143},
  year         = {2018},
}