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Imiquimod shows anti-viral actions in human bronchial epithelium - implications for COVID-19 treatment

Tillgren, Sofia LU orcid ; Nieto Fontarigo, Juan José LU ; Cerps, Samuel LU ; Hvidtfeldt, Morten ; Sverrild, Asger ; Porsbjerg, Celeste and Uller, Lena LU (2021) European Respiratory Society (ERS) congress 2021
Abstract
Combining anti-viral and anti-inflammatory effects in a single drug may be beneficial in treating COVID-19. We hypothesized that the TLR7 agonist imiquimod (imq) may exert these actions in human bronchial epithelial cells (HBECs), which are targets in SARS-CoV-2 mediated lung injury. Methods: Using primary HBECs from asthmatic donors (N=18), we explored actions of imq related to airway viral resistance and tolerance. HBECs were treated with imq alone or in combination with the viral mimic poly (I:C) or the SARS-CoV-2 spike protein 1 (SP1). Anti-viral and pro-inflammatory mediators were analyzed by Luminex, RT-qPCR and mRNA gene pathway analysis. Results: imq treatment alone induced IFN-ß and CCL5 (p
Abstract (Swedish)

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to conference
publication status
published
subject
keywords
Asthma, SARS-CoV-2, Imiquimod, TLR7
conference name
European Respiratory Society (ERS) congress 2021
conference dates
2021-09-05
language
English
LU publication?
yes
id
187929b4-3557-4c76-86f6-d0a809f8a84b
date added to LUP
2021-10-28 10:03:26
date last changed
2023-02-06 11:14:29
@misc{187929b4-3557-4c76-86f6-d0a809f8a84b,
  abstract     = {{Combining anti-viral and anti-inflammatory effects in a single drug may be beneficial in treating COVID-19. We hypothesized that the TLR7 agonist imiquimod (imq) may exert these actions in human bronchial epithelial cells (HBECs), which are targets in SARS-CoV-2 mediated lung injury. Methods: Using primary HBECs from asthmatic donors (N=18), we explored actions of imq related to airway viral resistance and tolerance. HBECs were treated with imq alone or in combination with the viral mimic poly (I:C) or the SARS-CoV-2 spike protein 1 (SP1). Anti-viral and pro-inflammatory mediators were analyzed by Luminex, RT-qPCR and mRNA gene pathway analysis. Results: imq treatment alone induced IFN-ß and CCL5 (p}},
  author       = {{Tillgren, Sofia and Nieto Fontarigo, Juan José and Cerps, Samuel and Hvidtfeldt, Morten and Sverrild, Asger and Porsbjerg, Celeste and Uller, Lena}},
  keywords     = {{Asthma; SARS-CoV-2; Imiquimod; TLR7}},
  language     = {{eng}},
  title        = {{Imiquimod shows anti-viral actions in human bronchial epithelium - implications for COVID-19 treatment}},
  url          = {{https://lup.lub.lu.se/search/files/108978995/Poster_Sofia_Tillgren.pdf}},
  year         = {{2021}},
}