Imiquimod shows anti-viral actions in human bronchial epithelium - implications for COVID-19 treatment
(2021) European Respiratory Society (ERS) congress 2021- Abstract
- Combining anti-viral and anti-inflammatory effects in a single drug may be beneficial in treating COVID-19. We hypothesized that the TLR7 agonist imiquimod (imq) may exert these actions in human bronchial epithelial cells (HBECs), which are targets in SARS-CoV-2 mediated lung injury. Methods: Using primary HBECs from asthmatic donors (N=18), we explored actions of imq related to airway viral resistance and tolerance. HBECs were treated with imq alone or in combination with the viral mimic poly (I:C) or the SARS-CoV-2 spike protein 1 (SP1). Anti-viral and pro-inflammatory mediators were analyzed by Luminex, RT-qPCR and mRNA gene pathway analysis. Results: imq treatment alone induced IFN-ß and CCL5 (p
- Abstract (Swedish)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/187929b4-3557-4c76-86f6-d0a809f8a84b
- author
- Tillgren, Sofia LU ; Nieto Fontarigo, Juan José LU ; Cerps, Samuel LU ; Hvidtfeldt, Morten ; Sverrild, Asger ; Porsbjerg, Celeste and Uller, Lena LU
- organization
- publishing date
- 2021
- type
- Contribution to conference
- publication status
- published
- subject
- keywords
- Asthma, SARS-CoV-2, Imiquimod, TLR7
- conference name
- European Respiratory Society (ERS) congress 2021
- conference dates
- 2021-09-05
- language
- English
- LU publication?
- yes
- id
- 187929b4-3557-4c76-86f6-d0a809f8a84b
- date added to LUP
- 2021-10-28 10:03:26
- date last changed
- 2023-02-06 11:14:29
@misc{187929b4-3557-4c76-86f6-d0a809f8a84b, abstract = {{Combining anti-viral and anti-inflammatory effects in a single drug may be beneficial in treating COVID-19. We hypothesized that the TLR7 agonist imiquimod (imq) may exert these actions in human bronchial epithelial cells (HBECs), which are targets in SARS-CoV-2 mediated lung injury. Methods: Using primary HBECs from asthmatic donors (N=18), we explored actions of imq related to airway viral resistance and tolerance. HBECs were treated with imq alone or in combination with the viral mimic poly (I:C) or the SARS-CoV-2 spike protein 1 (SP1). Anti-viral and pro-inflammatory mediators were analyzed by Luminex, RT-qPCR and mRNA gene pathway analysis. Results: imq treatment alone induced IFN-ß and CCL5 (p}}, author = {{Tillgren, Sofia and Nieto Fontarigo, Juan José and Cerps, Samuel and Hvidtfeldt, Morten and Sverrild, Asger and Porsbjerg, Celeste and Uller, Lena}}, keywords = {{Asthma; SARS-CoV-2; Imiquimod; TLR7}}, language = {{eng}}, title = {{Imiquimod shows anti-viral actions in human bronchial epithelium - implications for COVID-19 treatment}}, url = {{https://lup.lub.lu.se/search/files/108978995/Poster_Sofia_Tillgren.pdf}}, year = {{2021}}, }