The anti-angiogenic peptide anginex greatly enhances Galectin-1 binding affinity for glycoproteins
(2011) In Journal of Biological Chemistry 286(16). p.13801-13804- Abstract
Angiogenesis is a key event in cancer progression and therefore a promising target in cancer treatment. Galectin-1, a β-galactoside binding lectin, is up-regulated in the endothelium of tumors of different origin and has been shown to be the target for anginex, a powerful anti-angiogenic peptide with anti-tumor activity. Here we show that when bound to anginex, galectin-1 binds various glycoproteins with hundred-to thousand-fold higher affinity. Anginex also interacts with galectin-2,-7,-8N, and-9N but not with galectin-3,-4, or-9C.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1884385
- author
- Salomonsson, Emma LU ; Thijssen, Victor L. ; Griffioen, Arjan W. ; Nilsson, Ulf J. LU and Leffler, Hakon LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Biological Chemistry
- volume
- 286
- issue
- 16
- pages
- 4 pages
- publisher
- American Society for Biochemistry and Molecular Biology
- external identifiers
-
- wos:000289556200002
- pmid:21372130
- scopus:79954601101
- pmid:21372130
- ISSN
- 1083-351X
- DOI
- 10.1074/jbc.C111.229096
- language
- English
- LU publication?
- yes
- id
- dd31896a-adc8-42dd-8a9c-11029def289a (old id 1884385)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21372130?dopt=Abstract
- date added to LUP
- 2016-04-04 07:57:42
- date last changed
- 2023-02-15 16:37:41
@article{dd31896a-adc8-42dd-8a9c-11029def289a, abstract = {{<p>Angiogenesis is a key event in cancer progression and therefore a promising target in cancer treatment. Galectin-1, a β-galactoside binding lectin, is up-regulated in the endothelium of tumors of different origin and has been shown to be the target for anginex, a powerful anti-angiogenic peptide with anti-tumor activity. Here we show that when bound to anginex, galectin-1 binds various glycoproteins with hundred-to thousand-fold higher affinity. Anginex also interacts with galectin-2,-7,-8N, and-9N but not with galectin-3,-4, or-9C.</p>}}, author = {{Salomonsson, Emma and Thijssen, Victor L. and Griffioen, Arjan W. and Nilsson, Ulf J. and Leffler, Hakon}}, issn = {{1083-351X}}, language = {{eng}}, number = {{16}}, pages = {{13801--13804}}, publisher = {{American Society for Biochemistry and Molecular Biology}}, series = {{Journal of Biological Chemistry}}, title = {{The anti-angiogenic peptide anginex greatly enhances Galectin-1 binding affinity for glycoproteins}}, url = {{http://dx.doi.org/10.1074/jbc.C111.229096}}, doi = {{10.1074/jbc.C111.229096}}, volume = {{286}}, year = {{2011}}, }