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The anti-angiogenic peptide anginex greatly enhances galectin-1 binding affinity for glycoproteins.

Salomonsson, Emma LU ; Thijssen, Victor L; Griffioen, Arjan W; Nilsson, Ulf J and Leffler, Hakon LU (2011) In Journal of Biological Chemistry 286. p.13801-13804
Abstract
Angiogenesis is a key event in cancer progression and therefore a promising target in cancer treatment. Galectin-1, a β-galactoside binding lectin, is upregulated in the endothelium of tumors of different origin and has been shown to be the target for anginex, a powerful anti-angiogenic peptide with anti-tumor activity. Here we show that when bound to anginex, galectin-1 binds various glycoproteins with hundred to thousand fold higher affinity.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Biological Chemistry
volume
286
pages
13801 - 13804
publisher
ASBMB
external identifiers
  • wos:000289556200002
  • pmid:21372130
  • scopus:79954601101
ISSN
1083-351X
DOI
10.1074/jbc.C111.229096
language
English
LU publication?
yes
id
dd31896a-adc8-42dd-8a9c-11029def289a (old id 1884385)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21372130?dopt=Abstract
date added to LUP
2011-04-01 13:31:22
date last changed
2017-10-22 04:53:08
@article{dd31896a-adc8-42dd-8a9c-11029def289a,
  abstract     = {Angiogenesis is a key event in cancer progression and therefore a promising target in cancer treatment. Galectin-1, a β-galactoside binding lectin, is upregulated in the endothelium of tumors of different origin and has been shown to be the target for anginex, a powerful anti-angiogenic peptide with anti-tumor activity. Here we show that when bound to anginex, galectin-1 binds various glycoproteins with hundred to thousand fold higher affinity.},
  author       = {Salomonsson, Emma and Thijssen, Victor L and Griffioen, Arjan W and Nilsson, Ulf J and Leffler, Hakon},
  issn         = {1083-351X},
  language     = {eng},
  pages        = {13801--13804},
  publisher    = {ASBMB},
  series       = {Journal of Biological Chemistry},
  title        = {The anti-angiogenic peptide anginex greatly enhances galectin-1 binding affinity for glycoproteins.},
  url          = {http://dx.doi.org/10.1074/jbc.C111.229096},
  volume       = {286},
  year         = {2011},
}