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Distribution of melatonin receptors in murine pancreatic islets.

Nagorny, Cecilia LU ; Sathanoori, Ramasri LU ; Voss, Ulrikke LU ; Mulder, Hindrik LU and Wierup, Nils LU (2011) In Journal of Pineal Research 50. p.412-417
Abstract
Melatonin has multiple receptor-dependent and receptor-independent functions. At the cell membrane, melatonin interacts with its receptors MT1 and MT2, which are expressed in numerous tissues. Genome-wide association studies have recently shown that the MTNR1B/MT2 receptor may be involved in the pathogenesis of type 2 diabetes mellitus. In line with these findings, expression of melatonin receptors has been shown in mouse, rat, and human pancreatic islets. MT1 and MT2 are G-protein-coupled receptors and are proposed to exert inhibitory effects on insulin secretion. Here, we show by immunocytochemistry that these membrane melatonin receptors have distinct locations in the mouse islet. MT1 is expressed in α-cells while MT2 is located to the... (More)
Melatonin has multiple receptor-dependent and receptor-independent functions. At the cell membrane, melatonin interacts with its receptors MT1 and MT2, which are expressed in numerous tissues. Genome-wide association studies have recently shown that the MTNR1B/MT2 receptor may be involved in the pathogenesis of type 2 diabetes mellitus. In line with these findings, expression of melatonin receptors has been shown in mouse, rat, and human pancreatic islets. MT1 and MT2 are G-protein-coupled receptors and are proposed to exert inhibitory effects on insulin secretion. Here, we show by immunocytochemistry that these membrane melatonin receptors have distinct locations in the mouse islet. MT1 is expressed in α-cells while MT2 is located to the β-cells. These findings help to unravel the complex machinery underlying melatonin's role in the regulation of islet function. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Pineal Research
volume
50
pages
412 - 417
publisher
Wiley-Blackwell
external identifiers
  • wos:000289465800009
  • pmid:21355877
  • scopus:79954417344
ISSN
1600-079X
DOI
10.1111/j.1600-079X.2011.00859.x
language
English
LU publication?
yes
id
0f49c6e9-b173-4368-a3f4-ad24d7ebf485 (old id 1884581)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21355877?dopt=Abstract
date added to LUP
2011-04-01 08:20:08
date last changed
2017-11-12 04:07:08
@article{0f49c6e9-b173-4368-a3f4-ad24d7ebf485,
  abstract     = {Melatonin has multiple receptor-dependent and receptor-independent functions. At the cell membrane, melatonin interacts with its receptors MT1 and MT2, which are expressed in numerous tissues. Genome-wide association studies have recently shown that the MTNR1B/MT2 receptor may be involved in the pathogenesis of type 2 diabetes mellitus. In line with these findings, expression of melatonin receptors has been shown in mouse, rat, and human pancreatic islets. MT1 and MT2 are G-protein-coupled receptors and are proposed to exert inhibitory effects on insulin secretion. Here, we show by immunocytochemistry that these membrane melatonin receptors have distinct locations in the mouse islet. MT1 is expressed in α-cells while MT2 is located to the β-cells. These findings help to unravel the complex machinery underlying melatonin's role in the regulation of islet function.},
  author       = {Nagorny, Cecilia and Sathanoori, Ramasri and Voss, Ulrikke and Mulder, Hindrik and Wierup, Nils},
  issn         = {1600-079X},
  language     = {eng},
  pages        = {412--417},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of Pineal Research},
  title        = {Distribution of melatonin receptors in murine pancreatic islets.},
  url          = {http://dx.doi.org/10.1111/j.1600-079X.2011.00859.x},
  volume       = {50},
  year         = {2011},
}