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On the origin of myeloid-derived suppressor cells

Millrud, Camilla Rydberg LU ; Bergenfelz, Caroline LU and Leandersson, Karin LU (2017) In Oncotarget 8(2). p.3649-3665
Abstract

Myeloid-derived suppressor cells (MDSCs) have a strong immunosuppressive character that allows them to regulate immune responses and hinder overt inflammatory responses. In cancer, this leads to tumor immune evasion and disease progression. MDSCs come in at least two forms: monocytic (Mo-MDSCs) and granulocytic (G-MDSCs). The classical definition of MDSCs as immature myeloid cells blocked from differentiating has been challenged by recent studies suggesting that Mo-MDSCs and G-MDSCs may represent monocytes and granulocytes that have acquired immunosuppressive properties. The molecular mechanism behind their generation and their true origins are now widely debated. In this review we discuss the different proposed mechanisms of the... (More)

Myeloid-derived suppressor cells (MDSCs) have a strong immunosuppressive character that allows them to regulate immune responses and hinder overt inflammatory responses. In cancer, this leads to tumor immune evasion and disease progression. MDSCs come in at least two forms: monocytic (Mo-MDSCs) and granulocytic (G-MDSCs). The classical definition of MDSCs as immature myeloid cells blocked from differentiating has been challenged by recent studies suggesting that Mo-MDSCs and G-MDSCs may represent monocytes and granulocytes that have acquired immunosuppressive properties. The molecular mechanism behind their generation and their true origins are now widely debated. In this review we discuss the different proposed mechanisms of the generation of both types of MDSCs, with a special focus on human MDSCs in cancer.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Emergency myelopoiesis, Extramedullary, MDSC origin, Myelopoiesis, Reprogramming
in
Oncotarget
volume
8
issue
2
pages
17 pages
publisher
Impact Journals, LLC
external identifiers
  • scopus:85009822955
  • wos:000391506300144
ISSN
1949-2553
DOI
10.18632/oncotarget.12278
language
English
LU publication?
yes
id
18c5c7dd-9664-4c66-9b05-b6b5a36a7076
date added to LUP
2017-02-01 13:30:40
date last changed
2017-09-18 11:35:13
@article{18c5c7dd-9664-4c66-9b05-b6b5a36a7076,
  abstract     = {<p>Myeloid-derived suppressor cells (MDSCs) have a strong immunosuppressive character that allows them to regulate immune responses and hinder overt inflammatory responses. In cancer, this leads to tumor immune evasion and disease progression. MDSCs come in at least two forms: monocytic (Mo-MDSCs) and granulocytic (G-MDSCs). The classical definition of MDSCs as immature myeloid cells blocked from differentiating has been challenged by recent studies suggesting that Mo-MDSCs and G-MDSCs may represent monocytes and granulocytes that have acquired immunosuppressive properties. The molecular mechanism behind their generation and their true origins are now widely debated. In this review we discuss the different proposed mechanisms of the generation of both types of MDSCs, with a special focus on human MDSCs in cancer.</p>},
  author       = {Millrud, Camilla Rydberg and Bergenfelz, Caroline and Leandersson, Karin},
  issn         = {1949-2553},
  keyword      = {Emergency myelopoiesis,Extramedullary,MDSC origin,Myelopoiesis,Reprogramming},
  language     = {eng},
  number       = {2},
  pages        = {3649--3665},
  publisher    = {Impact Journals, LLC},
  series       = {Oncotarget},
  title        = {On the origin of myeloid-derived suppressor cells},
  url          = {http://dx.doi.org/10.18632/oncotarget.12278},
  volume       = {8},
  year         = {2017},
}