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Imaging the Tumor Antioxidant Response with [18F]FSPG PET

Timmermand, Oskar Vilhelmsson LU orcid and Witney, Timothy H (2024) In Methods in molecular biology (Clifton, N.J.) 2729. p.233-249
Abstract

(4S)-4-(3-[18F]Fluoropropyl)-L-glutamic acid ([18F]FSPG) is a flourine-18 labeled glutamate analog that enables the noninvasive in vivo imaging of cellular redox status. [18F]FSPG is transported across the cell membrane by the cystine/glutamate antiporter, system xc-, whose expression is upregulated in multiple cancer types. The requirement of cystine for the biosynthesis of glutathione, a major antioxidant, connects [18F]FSPG tissue retention to the intracellular redox response via system xc- activity. We herein describe the use of [18F]FSPG positron emission tomography (PET) to image the tumor antioxidant response and highlight key methodological considerations.

Please use this url to cite or link to this publication:
author
and
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Humans, Antioxidants, Cystine, Positron-Emission Tomography/methods, Neoplasms/diagnostic imaging, Glutamic Acid
host publication
Positron Emission Tomography
series title
Methods in molecular biology (Clifton, N.J.)
editor
Witney, Timothy H. and Shuhendler, Adam J.
volume
2729
pages
17 pages
publisher
Humana Press
external identifiers
  • pmid:38006500
  • scopus:85177728820
ISSN
1940-6029
ISBN
978-1-0716-3499-8
978-1-0716-3498-1
DOI
10.1007/978-1-0716-3499-8_14
language
English
LU publication?
no
additional info
© 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.
id
18dd3771-32f0-485d-bcb3-b522ecd1058e
date added to LUP
2024-09-26 15:11:18
date last changed
2025-10-25 17:43:54
@inbook{18dd3771-32f0-485d-bcb3-b522ecd1058e,
  abstract     = {{<p>(4S)-4-(3-[18F]Fluoropropyl)-L-glutamic acid ([18F]FSPG) is a flourine-18 labeled glutamate analog that enables the noninvasive in vivo imaging of cellular redox status. [18F]FSPG is transported across the cell membrane by the cystine/glutamate antiporter, system xc-, whose expression is upregulated in multiple cancer types. The requirement of cystine for the biosynthesis of glutathione, a major antioxidant, connects [18F]FSPG tissue retention to the intracellular redox response via system xc- activity. We herein describe the use of [18F]FSPG positron emission tomography (PET) to image the tumor antioxidant response and highlight key methodological considerations.</p>}},
  author       = {{Timmermand, Oskar Vilhelmsson and Witney, Timothy H}},
  booktitle    = {{Positron Emission Tomography}},
  editor       = {{Witney, Timothy H. and Shuhendler, Adam J.}},
  isbn         = {{978-1-0716-3499-8}},
  issn         = {{1940-6029}},
  keywords     = {{Humans; Antioxidants; Cystine; Positron-Emission Tomography/methods; Neoplasms/diagnostic imaging; Glutamic Acid}},
  language     = {{eng}},
  pages        = {{233--249}},
  publisher    = {{Humana Press}},
  series       = {{Methods in molecular biology (Clifton, N.J.)}},
  title        = {{Imaging the Tumor Antioxidant Response with [18F]FSPG PET}},
  url          = {{http://dx.doi.org/10.1007/978-1-0716-3499-8_14}},
  doi          = {{10.1007/978-1-0716-3499-8_14}},
  volume       = {{2729}},
  year         = {{2024}},
}